Type 1 interferon suppresses expression and glucocorticoid induction of glucocorticoid-induced leucine zipper (GILZ)

Autor: Wendy Dankers, Melissa Northcott, Taylah Bennett, Akshay D’Cruz, Rochelle Sherlock, Linden J. Gearing, Paul Hertzog, Brendan Russ, Iolanda Miceli, Sebastian Scheer, Maki Fujishiro, Kunihiro Hayakawa, Keigo Ikeda, Eric F. Morand, Sarah A. Jones

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

SLE is a systemic multi-organ autoimmune condition associated with reduced life expectancy and quality of life. Glucocorticoids (GC) are heavily relied on for SLE treatment but are associated with detrimental metabolic effects. Type 1 interferons (IF

Externí odkaz: https://doaj.org/article/3505bf1850804a299c6894502a57d398

Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages

Autor: Thao Thanh Tran, Carmen D. Mathmann, Marcela Gatica-Andrades, Rachel F. Rollo, Melanie Oelker, Johanna K. Ljungberg, Tam T. K. Nguyen, Alina Zamoshnikova, Lalith K. Kummari, Orry J. K. Wyer, Katharine M. Irvine, Javier Melo-Bolívar, Annette Gross, Darren Brown, Jeffrey Y. W. Mak, David P. Fairlie, Karl A. Hansford, Matthew A. Cooper, Rabina Giri, Veronika Schreiber, Shannon R. Joseph, Fiona Simpson, Timothy C. Barnett, Jörgen Johansson, Wendy Dankers, James Harris, Timothy J. Wells, Ronan Kapetanovic, Matthew J. Sweet, Eleanor A. Latomanski, Hayley J. Newton, Romain J. R. Guérillot, Abderrahman Hachani, Timothy P. Stinear, Sze Ying Ong, Yogeswari Chandran, Elizabeth L. Hartland, Bostjan Kobe, Jennifer L. Stow, A. Elisabeth Sauer-Eriksson, Jakob Begun, Jessica C. Kling, Antje Blumenthal

Publikováno v: PLoS Pathogens, Vol 18, Iss 1 (2022)

A hallmark of Listeria (L.) monocytogenes pathogenesis is bacterial escape from maturing entry vacuoles, which is required for rapid bacterial replication in the host cell cytoplasm and cell-to-cell spread. The bacterial transcriptional activator Prf

Externí odkaz: https://doaj.org/article/66dd0ab76b8e4e24a1aee04a59d0cdfa

1,25(OH)2D3 and dexamethasone additively suppress synovial fibroblast activation by CCR6+ T helper memory cells and enhance the effect of tumor necrosis factor alpha blockade

Autor: Wendy Dankers, Claudia González-Leal, Nadine Davelaar, Patrick S. Asmawidjaja, Adriana M. C. Mus, Johanna M. W. Hazes, Edgar M. Colin, Erik Lubberts

Publikováno v: Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-10 (2018)

Abstract Background Despite recent improvements in the treatment of rheumatoid arthritis (RA), an insufficient treatment response and the development of treatment resistance in many patients illustrates the need for new therapeutic strategies. Chroni

Externí odkaz: https://doaj.org/article/3a07dc2ca00a40bcbb47638e4912b65b

Could GILZ Be the Answer to Glucocorticoid Toxicity in Lupus?

Autor: Jacqueline K. Flynn, Wendy Dankers, Eric F. Morand

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Glucocorticoids (GC) are used globally to treat autoimmune and inflammatory disorders. Their anti-inflammatory actions are mainly mediated via binding to the glucocorticoid receptor (GR), creating a GC/GR complex, which acts in both the cytoplasm and

Externí odkaz: https://doaj.org/article/17520fe3534445bca754595b1ba8b1df

The heterogeneous human memory CCR6+ T helper-17 populations differ in T-bet and cytokine expression but all activate synovial fibroblasts in an IFNγ-independent manner

Autor: Hannah den Braanker, Jan Piet van Hamburg, Wendy Dankers, Erik Lubberts, Nadine Davelaar, Sandra M. J. Paulissen, E. M. Colin

Publikováno v: Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-14 (2021)
Arthritis research & therapy, 23(1):157. BioMed Central
Arthritis Research and Therapy, 23(1):157. BioMed Central Ltd.

Background Chronic synovial inflammation is an important hallmark of inflammatory arthritis, but the cells and mechanisms involved are incompletely understood. Previously, we have shown that CCR6+ memory T-helper (memTh) cells and synovial fibroblast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795f7dc24a0cf3004bc454e0fdadf116
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