Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Wendy, Collard"'
Autor:
Matthew J. Krautmann, Sean Mahabir, Ann Fielder, Wendy Collard, Tracie L. Wolthuis, Kevin Esch, Tracy Morton, Kent Alleman, Laibin Luo, Erin McCandless, Steven Nederveld, Kristina Kryda, Ryan Carroll, Joseph F. Boucher
Publikováno v:
Parasites & Vectors, Vol 12, Iss 1, Pp 1-13 (2019)
Abstract Background The safety of ProHeart® 12 (PH 12; extended-release injectable suspension; 10% moxidectin in glyceryl tristearate microspheres) was evaluated in four studies using Beagle dogs and one study using ivermectin-sensitive Collies. The
Externí odkaz:
https://doaj.org/article/2f4ea87ddf2d47de8f22a28cbe442e50
Autor:
Tracey Williams, Rajendran Vairagoundar, Julie A. White, Dennis L Huczek, Respondek Tomasz, Jason T. Ross, Johnson Paul D, Carolyn Hedke, Andrea J Gonzales, Govindan Subramanian, Christopher Javens, Todd Maddux, Brian A. Duclos, Theresa Zachary, Mark R Cox, Wendy Collard, Yaqi Zhu, Steven Kamerling, Scott J. Bowen
Publikováno v:
ACS Medicinal Chemistry Letters. 12:1847-1852
Human β-nerve growth factor (β-NGF) and its associated receptor, human tropomyosin receptor kinase A (hTrkA), have been demonstrated to be key factors in the perception of pain. However, efficacious small molecule therapies targeting the intracellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6630b824f3daa850025a3853fdae724
https://doi.org/10.1021/acsmedchemlett.1c00483
https://doi.org/10.1021/acsmedchemlett.1c00483
Autor:
Govindan, Subramanian, Brian, Duclos, Paul D, Johnson, Tracey, Williams, Jason T, Ross, Scott J, Bowen, Yaqi, Zhu, Julie A, White, Carolyn, Hedke, Dennis, Huczek, Wendy, Collard, Christopher, Javens, Rajendran, Vairagoundar, Tomasz, Respondek, Theresa, Zachary, Todd, Maddux, Mark R, Cox, Steven, Kamerling, Andrea J, Gonzales
Publikováno v:
ACS Med Chem Lett
[Image: see text] Human β-nerve growth factor (β-NGF) and its associated receptor, human tropomyosin receptor kinase A (hTrkA), have been demonstrated to be key factors in the perception of pain. However, efficacious small molecule therapies target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fc2cffcee3fe711d396c4c194701a46f
https://pubmed.ncbi.nlm.nih.gov/34795875
https://pubmed.ncbi.nlm.nih.gov/34795875
Autor:
Joseph F. Boucher, Steven Nederveld, Ryan Carroll, Matthew J. Krautmann, Kent Alleman, Erin E. McCandless, Kristina Kryda, Kevin J. Esch, Wendy Collard, Tracy Morton, Tracie L. Wolthuis, Laibin Luo, Ann Fielder, Sean P. Mahabir
Publikováno v:
Parasites & Vectors, Vol 12, Iss 1, Pp 1-13 (2019)
Background The safety of ProHeart® 12 (PH 12; extended-release injectable suspension; 10% moxidectin in glyceryl tristearate microspheres) was evaluated in four studies using Beagle dogs and one study using ivermectin-sensitive Collies. The recommen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f0fb561b9b89f2beb6975fe8a1c6882
https://doi.org/10.1186/s13071-019-3690-6
https://doi.org/10.1186/s13071-019-3690-6
Autor:
Penny Oxley, Natilie Hosea, Jing Lin, Barry Jones, Kenny J. Watson, Steve S. Gernhardt, S Ravi Rahavendran, Wendy Collard, Maurice Dickins, Iain Gardner, Susan Cole, Vikas Kumar, Henry Pertinez, Hannah M. Jones, Phil J Stanley, David R. Plowchalk
Publikováno v:
Clinical Pharmacokinetics. 50:331-347
Background: The importance of predicting human pharmacokinetics during compound selection has been recognized in the pharmaceutical industry. To this end there are many different approaches that are applied. Methods: In this study we compared the acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff8b11c8df2d280bfb4459c3ce87510
https://doi.org/10.2165/11539680-000000000-00000
https://doi.org/10.2165/11539680-000000000-00000
Autor:
Christopher F. Bigge, Teresa Padalino, James Pulaski, Kun Song, Wendy Collard, Kimberly A. Stevens, Christopher D. Kane, Lori Royer, Agustin Casimiro-Garcia, Bruce Auerbach, Jo Ann Davis, Patrick I. McConnell, Christine McGregor, Jeffrey F. Ohren
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:7113-7125
The synthesis of a new series of phenylpropanoic acid derivatives incorporating an heteroaryl group at the α-position and their evaluation for binding and activation of PPARα and PPARγ are presented in this report. Among the new compounds, (S)-3-{
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1484b43f9d94b76c090d92e541a050a2
https://doi.org/10.1016/j.bmc.2009.09.001
https://doi.org/10.1016/j.bmc.2009.09.001
Autor:
Hannah M. Jones, Susan Cole, Bill J. Smith, Rick X. Fang, Kevin Beaumont, Rob Webster, Tristan S. Maurer, Wendy Collard, Shefali Kakar, Natilie Hosea, Yasuhiro Nakai
Publikováno v:
The Journal of Clinical Pharmacology. 49:513-533
Quantitative prediction of human pharmacokinetics is critical in assessing the viability of drug candidates and in determining first-in-human dosing. Numerous prediction methodologies, incorporating both in vitro and preclinical in vivo data, have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b00f9b338d40af3edb6426552ab02801
https://doi.org/10.1177/0091270009333209
https://doi.org/10.1177/0091270009333209
Autor:
Chad A. Van Huis, Wendy Collard, Cuiman Cai, Michelle Mastronardi, Roxane Collins, Michael J. Ryan, Jeremy J. Edmunds, Erli Zhang, Mehran Jalaie, Chungang Gu, Ken Mennen, John W. Bryant, Patrick I. McConnell, Fred L. Ciske, Suzie Ferreira, Jacqueline E. Day, Daniel D. Holsworth, Noel A. Powell, Igor Mochalkin
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:5912-5949
We report the design and synthesis of a series of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as orally bioavailable small molecule inhibitors of renin. Compounds with a 2-methyl-2-aryl substitution pattern exhibit potent renin inhibition and go
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5134728dfb02df8a38ff3f31d48c05e
https://doi.org/10.1016/j.bmc.2007.05.069
https://doi.org/10.1016/j.bmc.2007.05.069
Autor:
Debra J. Woods, Xin Zhou, David P. Thompson, Alan A. Marchiondo, Christopher S. Knauer, Matthew J. Zaya, Steven X. Hu, Julie K. Lorenz, Wendy Collard, Bernard D Hummel, Dawn A. Merritt, Jinxia Nancy Deng
Publikováno v:
The Journal of parasitology. 100(6)
The objective of the current study was to establish an in vitro screen and a highly sensitive analytical assay to delineate key physicochemical properties that favor compound bioaccumulation in the L3 life stage of a Haemonchus contortus isolate. Tim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::116b2400eea8841a60fb0d2ab2dd7969
https://pubmed.ncbi.nlm.nih.gov/25116000
https://pubmed.ncbi.nlm.nih.gov/25116000
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 759:277-284
Cyclophosphamide (CP) and its metabolite, hydroxycyclophosphamide (OH-CP) have been quantitated in mouse plasma and tissue by derivatization combined with liquid chromatography–tandem mass spectrometry (LC–MS–MS). The derivatization was conduct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7702f1cec60587f43076b307dc4cd18f
https://doi.org/10.1016/s0378-4347(01)00243-2
https://doi.org/10.1016/s0378-4347(01)00243-2