Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Wendy, Clarke"'
Autor:
Regina Miller, Nicholas J. Lodge, John E. Macor, Wendy Clarke, Lizbeth Gallagher, Linda J. Bristow, Daniel G. Morgan, Christiana I. Iwuagwu, Ryan Westphal, Haiquan Fang, Kimberley A. Lentz, Debra J. Post-Munson, Amy Easton, Matthew D. Hill, Bei Wang, Robert A. Mate, Ivar M. McDonald, James H. Cook, Yulia Benitex, Dalton King, Thaddeus F. Molski, Ronald J. Knox, F. Christopher Zusi, Richard E. Olson, Rex Denton, Jingsong Fan, Rulin Zhao, Robert Zaczek
Publikováno v:
ACS Medicinal Chemistry Letters. 8:366-371
The therapeutic treatment of negative symptoms and cognitive dysfunction associated with schizophrenia is a significant unmet medical need. Preclinical literature indicates that α7 neuronal nicotinic acetylcholine (nACh) receptor agonists may provid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4993c640b254a344e08c8bc412ffe3
https://doi.org/10.1021/acsmedchemlett.7b00032
https://doi.org/10.1021/acsmedchemlett.7b00032
Autor:
Ivar M. McDonald, Wang Nenghui, Victor R. Guarino, Kimberley A. Lentz, Richard E. Olson, Wendy Clarke, Roy Haskell, J. Gerry Everlof
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(3)
The objective of this Letter is to report the first (to our knowledge) in vivo proof of concept for a sulfenamide prodrug to orally deliver a poorly soluble drug containing a weakly-acidic NH–acid from a conventional solid dosage formulation. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07dd39c1805268048faa33aa27a7d547
https://pubmed.ncbi.nlm.nih.gov/31870650
https://pubmed.ncbi.nlm.nih.gov/31870650
Autor:
John Morrison, Kenneth M. Boy, Alan S. Robertson, Malaz AbuTarif, Jeremy H. Toyn, Valerie Guss, Xiaoliang Zhuo, Maciej Gasior, James E. Grace, Cong Wei, Jun-Sheng Wang, Quan Hong, Joseph Raybon, Lynda S. Cook, Nina Hoque, Richard E. Olson, Wendy Clarke, Rex Denton, Lorin A. Thompson, Francis Sweeney, Flora Berisha, Jere E. Meredith, Dieter M. Drexler, Holly Soares, Kimberly A. Lentz, Charlie F. Albright, Ramesh Padmanabha, Michael J. Furlong, John E. Macor, Michael K. Ahlijanian, Dmitry Zuev, Kimberly Snow
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics
The amyloid-β peptide (Aβ)-in particular, the 42-amino acid form, Aβ1-42-is thought to play a key role in the pathogenesis of Alzheimer's disease (AD). Thus, several therapeutic modalities aiming to inhibit Aβ synthesis or increase the clearance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c27817650721b910af7d1d2e922680b
https://doi.org/10.1124/jpet.116.232249
https://doi.org/10.1124/jpet.116.232249
Autor:
Matt Pokross, Jonathan Lippy, Guanglin Luo, Vinod Arora, Hong Xiao, Nengyin Liu, John E. Macor, Joseph Raybon, Wendy Clarke, Catherine R. Burton, David R. Langley, Carol M. Krause, Gene M. Dubowchik, Yang Cao, Ling Chen, Hal A. Lewis, Kimberly Snow, Prasanna Sivaprakasam, Kevin Kish
Publikováno v:
Journal of Medicinal Chemistry. 59:1041-1051
GSK-3 is a serine/threonine kinase that has numerous substrates. Many of these proteins are involved in the regulation of diverse cellular functions, including metabolism, differentiation, proliferation, and apoptosis. Inhibition of GSK-3 may be usef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af6b7565032e7ab38f139d202ec3bbb6
https://doi.org/10.1021/acs.jmedchem.5b01550
https://doi.org/10.1021/acs.jmedchem.5b01550
Publikováno v:
Poster presentations.
Background Healthcare settings have traditionally focused on developing safe systems by learning from incidents and errors (Kelly, Blake & Plunkett, 2016). Considerable time and energy is spent on activities including incident reporting and root caus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2b4263f2836076ef68c7e31b1591efb
https://doi.org/10.1136/bmjspcare-2018-hospiceabs.264
https://doi.org/10.1136/bmjspcare-2018-hospiceabs.264
Autor:
Shuanghua Hu, Wendy Clarke, Yazhong Huang, John B. Hogan, Lawrence G. Iben, Graham S. Poindexter, Gail K. Mattson, Ling Chen, Guanglin Luo, John W. Russell, Ildiko Antal-Zimanyi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3814-3817
A convergent synthesis route for the heterocyclic modification of a novel bicyclo[3.1.0]hexane NPY1 antagonist 2 was developed and the structure activity relationship of these modifications on NPY1 binding is reported. Two heterocyclic analogs 9 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800f1807028db0439bba719aa1a01b3a
https://doi.org/10.1016/j.bmcl.2013.04.095
https://doi.org/10.1016/j.bmcl.2013.04.095
Autor:
Regina Miller, Michele Matchett, Nicholas J. Lodge, Yulia Benitex, Thaddeus F. Molski, Wendy Clarke, John E. Macor, Rulin Zhao, Robert Zaczek, Linda J. Bristow, Amy Easton, Christiana I. Iwuagwu, JoAnne E Natale, Haiquan Fang, Ronald J. Knox, Baoqing Ma, F. Christopher Zusi, Siva Digavalli, James H. Cook, Matthew D. Hill, Francine L. Healy, Debra J. Post-Munson, Jingfang Qian Cutrone, Daniel G. Morgan, Bei Wang, Richard E. Olson, Qi Gao, Rex Denton, Robert A. Mate, Ivar M. McDonald, Dalton King, Meredith Ferrante, Kimberley A. Lentz, Kelli M. Jones, Judith A. Siuciak, Lizbeth Gallagher
Publikováno v:
Journal of medicinal chemistry. 59(24)
The design and synthesis of a series of quinuclidine-containing spirooxazolidines (“spiroimidates”) and their utility as α7 nicotinic acetylcholine receptor partial agonists are described. Selected members of the series demonstrated excellent se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7168f463fa8dafe0bc3dd8512c11678
https://pubmed.ncbi.nlm.nih.gov/27958732
https://pubmed.ncbi.nlm.nih.gov/27958732
Autor:
Daniel G. Morgan, Wendy Clarke, Nicholas J. Lodge, Yulia Benitex, John E. Macor, Debra J. Post-Munson, Ivar M. McDonald, Richard E. Olson, Dalton King, Rex Denton, Amy Easton, Ronald J. Knox, Kimberley A. Lentz, Christiana I. Iwuagwu, Matthew D. Hill, F. Christopher Zusi, Haiquan Fang, Robert Zaczek, Linda J. Bristow, Robert A. Mate, James H. Cook, Regina Miller
We describe the synthesis of quinuclidine-containing spiroimidates and their utility as α7 nicotinic acetylcholine receptor (nAChR) partial agonists. A convergent synthetic route allowed for rapid SAR investigation and provided a diverse set of fuse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c72cac8d11dcb33041f5390751e60f
https://europepmc.org/articles/PMC5238485/
https://europepmc.org/articles/PMC5238485/
Autor:
Dolatrai M. Vyas, Krista Menard, Joan M. Carboni, David B. Frennesson, Marco M. Gottardis, Kurt Zimmermann, Ann Greer, Upender Velaparthi, Francis Y. Lee, Saulnier Mark G, Peiying Liu, George L. Trainor, Aixin Li, Mark D. Wittman, Wendy Clarke, Zheng Yang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3182-3185
A series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one were synthesized to modulate CYP3A4 inhibition and improve aqueous solubility of our prototypical compound BMS-536924 (1), while maintaining potent IGF-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090631c209c36322e1108606af52219f
https://doi.org/10.1016/j.bmcl.2010.03.057
https://doi.org/10.1016/j.bmcl.2010.03.057
Publikováno v:
Health Education Journal. 68:119-129
Changes in the prevalence of oral diseases and the funding of National Health Service Dentistry in the United Kingdom have combined to emphasize the role of the dental team in the prevention of disease. As part of this, oral health promotion plays a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b350d3df54d5fe364df005e3cd0e3940
https://doi.org/10.1177/0017896909103848
https://doi.org/10.1177/0017896909103848