Zobrazeno 1 - 10 of 24 pro vyhledávání: '"Wendy, Beattie"'
1
Akademický článek
SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication
Autor: Augusto C. Montezano, Livia L. Camargo, Sheon Mary, Karla B Neves, Francisco J Rios, Ross Stein, Rheure A. Lopes, Wendy Beattie, Jacqueline Thomson, Vanessa Herder, Agnieszka M. Szemiel, Steven McFarlane, Massimo Palmarini, Rhian M. Touyz
Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract COVID-19, caused by SARS-CoV-2, is a respiratory disease associated with inflammation and endotheliitis. Mechanisms underling inflammatory processes are unclear, but angiotensin converting enzyme 2 (ACE2), the receptor which binds the spike
Externí odkaz: https://doaj.org/article/e05cdc1398a34aa49f53b13c0a5c14a8
Zobrazit plný text záznamu
2
Akademický článek
Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction
Autor: Amit Mahindra, Gonzalo Tejeda, Mario Rossi, Omar Janha, Imogen Herbert, Caroline Morris, Danielle C. Morgan, Wendy Beattie, Augusto C. Montezano, Brian Hudson, Andrew B. Tobin, David Bhella, Rhian M. Touyz, Andrew G. Jamieson, George S. Baillie, Connor M. Blair
Publikováno v: PLoS ONE, Vol 16, Iss 11 (2021)
SARS-CoV-2 viral attachment and entry into host cells is mediated by a direct interaction between viral spike glycoproteins and membrane bound angiotensin-converting enzyme 2 (ACE2). The receptor binding motif (RBM), located within the S1 subunit of
Externí odkaz: https://doaj.org/article/f0f07f9a6ed44895934fa969a58c9b5e
Zobrazit plný text záznamu
3
Osteoprotegerin regulates vascular function through syndecan-1 and NADPH oxidase-derived reactive oxygen species
Autor: Laura Haddow, Augusto C. Montezano, Karla B Neves, Rheure Alves-Lopes, Jennifer Dyet, Hiba Yusuf, Adam Harvey, Ross Hepburn, Delyth Graham, Wendy Beattie, John P. McAbney, Susan Haniford, Katie Y. Harvey, Anastasiya Strembitska
Publikováno v: Clinical Science. 135:2429-2444
Osteogenic factors, such as osteoprotegerin (OPG), are protective against vascular calcification. However, OPG is also positively associated with cardiovascular damage, particularly in pulmonary hypertension, possibly through processes beyond effects
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91969c8fddb82fb7cfb8537025de7c5d
https://doi.org/10.1042/cs20210643
Zobrazit plný text záznamu
4
Abstract 127: Nox5 Expression In A Vascular Smooth Muscle Cell-specific Manner Induces Fibroblast To Myofibroblast Differentiation
Autor: Augusto C Montezano, Francisco J Rios, Zachariel Blaikie, Tomador E Saad, Livia Camargo, Wendy Beattie, Frederic Jaisser, Tomasz Guzik, Delyth Graham, Rhian M Touyz
Publikováno v: Hypertension. 79
Mice expressing human Nox5 (hNox5) in VSMC exhibit cardfiovascular fibrosis, where mechanisms are unknown. We postulated that VSMC-Nox5 promotes fibroblast to myofibroblast differentiation that contributes to fibrosis. Fibroblasts were cultured from
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4792be6ac0782406934a9fab4169067b
https://doi.org/10.1161/hyp.79.suppl_1.127
Zobrazit plný text záznamu
8
Abstract 40: SARS-CoV-2/ACE2 Induces Vascular Inflammatory Responses In Human Microvascular Endothelial Cells Independently Of Viral Replication
Autor: Imogen Herbert, Agnieszka M. Szemiel, Rhian M. Touyz, Augusto C. Montezano, Vanessa Herder, Francisco J. Rios, Livia L Camargo, Steven McFarlane, Sheon Mary, Massimo Palmarini, Rheure Alves-Lopes, David Bhella, Wendy Beattie, Karla B Neves
Publikováno v: Hypertension. 78
SARS-CoV-2, the virus responsible for COVID19, binds to ACE2, via its spike protein S1 subunit, leading to viral infection and respiratory disease. COVID-19 is associated with cardiovascular disease and systemic inflammation. Since ACE2 is expressed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::adf371e671715f200cfbee6f1939ac19
https://doi.org/10.1161/hyp.78.suppl_1.40
Zobrazit plný text záznamu
10
ACE2 and Proinflammatory Signaling by S1 Protein of SARS‐Cov‐2 in Human Endothelial Cells
Autor: Wendy Beattie, Augusto C. Montezano, Livia L Camargo, Rheure A Lopes, Stuart A. Nicklin, Karla B Neves, Colin Berry, Rhian M. Touyz, Francisco J. Rios
Publikováno v: The FASEB Journal
Introduction COVID‐19 is primarily a respiratory disease associated with cardiovascular risk. SARS‐CoV‐2, the virus causing COVID‐19, uses ACE2, an important enzyme in the cardiovascular system that regulates the conversion of Ang II (deleter
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f163dee33fc4675ae1bf42e2dc68dc8b
http://europepmc.org/articles/PMC8239669
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje