Abundant HIV-infected cells in blood and tissues are rapidly cleared upon ART initiation during acute HIV infection

Autor: Timothy W. Schacker, Mark de Souza, Donn J Colby, Sopark Manasnayakorn, Louise Leyre, Merlin L. Robb, Sodsai Tovanabutra, Eugene Kroon, Praphan Phanuphak, Suthat Chottanapund, Lydie Trautmann, Search study groups Search, Jintanat Ananworanich, Jerome H. Kim, Carlo Sacdalan, Wendy Bakeman, Alexandra Schuetz, Nicolas Chomont, Nelson L. Michael, Supranee Buranapraditkun, Nittaya Phanuphak, Rémi Fromentin, Victor Valcour, Robert J. O'Connell, Nitiya Chomchey, Siriwat Akapirat, Suteeraporn Pinyakorn, Rungsun Rerknimitr, Claire Vandergeeten, Phandee Wattanaboonyoungcharoen, Rv Search Rv Search, Rapee Trichavaroj

Publikováno v: Science translational medicine, 12(533):eaav3491. American Association for the Advancement of Science
Sci Transl Med

The timing and location of the establishment of the viral reservoir during acute HIV infection remain unclear. Using longitudinal blood and tissue samples obtained from HIV-infected individuals at the earliest stage of infection, we demonstrate that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a82a1ec8be8b5edf2dcd60dd314360
http://www.scopus.com/inward/record.url?scp=85081333117&partnerID=8YFLogxK

Nef promotes evasion of human immunodeficiency virus type 1-infected cells from the CTLA-4-mediated inhibition of T-cell activation

Autor: Tévy Suzy Tep, Wendy Bakeman, Gordon J. Freeman, Yuwei Zhang, Quentin Eichbaum, Olivier Schwartz, Sandrina DaFonseca, Mohamed El-Far, Annie Gosselin, Elias K. Haddad, Rebeka Bordi, Elias A. Said, Nicolas Chomont, Petronela Ancuta, Rafick Pierre Sekaly, Jean-Pierre Routy, Julien van Grevenynghe

Publikováno v: Journal of General Virology
Journal of General Virology, Microbiology Society, 2015, 96 (Pt 6), pp.1463-77. ⟨10.1099/vir.0.000065⟩
Journal of General Virology, 2015, 96 (Pt 6), pp.1463-77. ⟨10.1099/vir.0.000065⟩

International audience; CTLA-4 is a negative regulator of T-cell receptor-mediated CD4(+) T-cell activation and function. Upregulation of CTLA-4 during human immunodeficiency virus type 1 (HIV-1) infection on activated T cells, particularly on HIV-sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e68eff0351ba8e8a985074d111f9ec
https://doi.org/10.1099/vir.0.000065

Exhaustion of Activated CD8 T cells Predicts Disease Progression in Primary HIV-1 Infection

Autor: Rebecca Hoh, Wendy Bakeman, Marisela Killian, Elizabeth Sinclair, Frederick Hecht, Steven G. Deeks, Wendy Hartogensis, Nicolas Chomont, Rémi Fromentin, Lorrie Epling, Rafick Pierre Sekaly, Gabriela Khoury, Sandrina DaFonseca, Sharon R Lewin, Peter Bacchetti, Mariam B. Lawani

Publikováno v: PLoS pathogens, vol 12, iss 7
PLoS Pathogens
PLoS Pathogens, Vol 12, Iss 7, p e1005761 (2016)

HIV persists in a small pool of latently infected cells despite antiretroviral therapy (ART). Identifying cellular markers expressed at the surface of these cells may lead to novel therapeutic strategies to reduce the size of the HIV reservoir. We hy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff24dc15a5f1155b88b7655ff3497d9
https://escholarship.org/uc/item/6nv1p8px

Reduced markers of HIV persistence and restricted HIV-specific immune responses after early antiretroviral therapy in children

Autor: Jintanat, Ananworanich, Thanyawee, Puthanakit, Piyarat, Suntarattiwong, Kulkanya, Chokephaibulkit, Stephen J, Kerr, Rémi, Fromentin, Wendy, Bakeman, Jintana, Intasan, Apicha, Mahanontharit, Sunee, Sirivichayakul, Nicolas, Chomont, Patiwat, Kadeelok

Publikováno v: AIDS (London, England). 28(7)

OBJECTIVE Understanding the extent to which early antiretroviral therapy (ART) can limit the establishment and persistence of the HIV reservoir is an important step to designing interventions aimed at achieving HIV cure. We measured the markers of HI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6edb24d6dbdd7b563e5aef34e502ad5d
https://pubmed.ncbi.nlm.nih.gov/24685744

Potent suppression of HIV viral replication by a novel inhibitor of Tat

Autor: Susana T. Valente, Michael D. Cameron, Wendy Bakeman, Nicolas Chomont, Phil S. Baran, Jun Shi, Nisha Nagarsheth, Guillaume Mousseau, Mark A. Clementz, Rémi Fromentin

Publikováno v: Retrovirology
Retrovirology, Vol 9, Iss Suppl 1, p O11 (2012)

Background Tat, the HIV Trans-Activator of Transcription is a potential antiviral target. Tat binds to the 5’ terminal region of HIV mRNAs stem-bulge-loop structure called the Trans-activation Responsive (TAR) element and activates transcription fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c34a581747a4c7aaa7183ece853e84
http://europepmc.org/articles/PMC3360218