Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer's disease.

Autor: Zatcepin A; Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany. Artem.Zatcepin@med.uni-muenchen.de.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. Artem.Zatcepin@med.uni-muenchen.de., Gnörich J; Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Rauchmann BS; Institute of Neuroradiology, University Hospital LMU, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany., Bartos LM; Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany., Wagner S; Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany., Franzmeier N; Institute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich, Munich, Germany.; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Malpetti M; Department of Clinical Neurosciences, Cambridge University Hospitals NHS Trust, University of Cambridge, Cambridge, UK., Xiang X; Biomedical Center (BMC), Division of Metabolic Biochemistry, Faculty of Medicine, LMU Munich, Munich, Germany.; CAS Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute, Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, ShenzhenShenzhen, 518055, China., Shi Y; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Parhizkar S; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA., Grosch M; German Center for Vertigo and Balance Disorders, University Hospital of Munich, LMU Munich, Munich, Germany., Wind-Mark K; Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Kunte ST; Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany., Beyer L; Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany., Meyer C; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Brösamle D; German Center for Neurodegenerative Disease (DZNE), Neuroimmunology and Neurodegenerative Diseases, Göttingen, Germany.; Dept. of Cellular Neurology, Hertie Institute for Clinical Brain Research, Tübingen, Germany.; Metabolic Biochemistry, Faculty of Medicine, Biomedical Center Munich (BMC), LMU Munich, Munich, Germany., Wendeln AC; German Center for Neurodegenerative Disease (DZNE), Neuroimmunology and Neurodegenerative Diseases, Göttingen, Germany.; Dept. of Cellular Neurology, Hertie Institute for Clinical Brain Research, Tübingen, Germany., Osei-Sarpong C; Platform for Single Cell Genomics and Epigenomics (PRECISE), German Center for Neurodegenerative Diseasesand , University of Bonn and West German Genome Center, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Immunogenomics & Neurodegeneration, Bonn, Germany., Heindl S; Institute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich, Munich, Germany., Liesz A; Institute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Stoecklein S; Department of Radiology, University Hospital, LMU Munich, Munich, Germany., Biechele G; Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany.; Department of Radiology, University Hospital, LMU Munich, Munich, Germany., Finze A; Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany., Eckenweber F; Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany., Lindner S; Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany., Rominger A; Department of Nuclear Medicine, Inselpital, Bern University Hospital, University of Bern, Bern, Switzerland., Bartenstein P; Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany., Willem M; Biomedical Center (BMC), Division of Metabolic Biochemistry, Faculty of Medicine, LMU Munich, Munich, Germany., Tahirovic S; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Herms J; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Center for Neuropathology and Prion Research, LMU Munich, Munich, Germany., Buerger K; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Institute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich, Munich, Germany., Simons M; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Institute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany., Haass C; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Biomedical Center (BMC), Division of Metabolic Biochemistry, Faculty of Medicine, LMU Munich, Munich, Germany., Rupprecht R; Department of Psychiatry and Psychotherapy, University of Regensburg, Molecular Neurosciences, Regensburg, Germany., Riemenschneider MJ; Department of Neuropathology, Regensburg University Hospital, Regensburg, Germany., Albert NL; Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany.; German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Partner Site Munich, 69120, Heidelberg, Germany.; Bavarian Cancer Research Center (BZKF), 91054, Erlangen, Germany., Beyer M; Platform for Single Cell Genomics and Epigenomics (PRECISE), German Center for Neurodegenerative Diseasesand , University of Bonn and West German Genome Center, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE), Immunogenomics & Neurodegeneration, Bonn, Germany., Neher JJ; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; German Center for Neurodegenerative Disease (DZNE), Neuroimmunology and Neurodegenerative Diseases, Göttingen, Germany.; Dept. of Cellular Neurology, Hertie Institute for Clinical Brain Research, Tübingen, Germany.; Metabolic Biochemistry, Faculty of Medicine, Biomedical Center Munich (BMC), LMU Munich, Munich, Germany., Paeger L; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Levin J; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Department of Neurology, University Hospital, LMU Munich, Munich, Germany., Höglinger GU; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Department of Neurology, University Hospital, LMU Munich, Munich, Germany.; Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany., Perneczky R; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Ageing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London, London, W6 8RP, UK.; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, S10 2HQ, UK., Ziegler SI; Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany., Brendel M; Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

Publikováno v: Molecular neurodegeneration [Mol Neurodegener] 2024 Sep 05; Vol. 19 (1), pp. 64. Date of Electronic Publication: 2024 Sep 05.

Innate immune memory in the brain shapes neurological disease hallmarks.

Autor: Wendeln AC; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; Graduate School of Cellular and Molecular Neuroscience, University of Tübingen, Tübingen, Germany., Degenhardt K; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; Graduate School of Cellular and Molecular Neuroscience, University of Tübingen, Tübingen, Germany., Kaurani L; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.; Department for Systems Medicine and Epigenetics in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Gertig M; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.; Department for Systems Medicine and Epigenetics in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Ulas T; Genomics and Immunoregulation, LIMES-Institute, University of Bonn, Bonn, Germany., Jain G; Department for Systems Medicine and Epigenetics in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.; Bioinformatics Unit, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Wagner J; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; Graduate School of Cellular and Molecular Neuroscience, University of Tübingen, Tübingen, Germany., Häsler LM; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Wild K; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Skodras A; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Blank T; Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Staszewski O; Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Datta M; Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Centeno TP; Department for Systems Medicine and Epigenetics in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.; Bioinformatics Unit, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Capece V; Department for Systems Medicine and Epigenetics in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.; Bioinformatics Unit, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Islam MR; Department for Systems Medicine and Epigenetics in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Kerimoglu C; Department for Systems Medicine and Epigenetics in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Staufenbiel M; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Schultze JL; Genomics and Immunoregulation, LIMES-Institute, University of Bonn, Bonn, Germany.; Platform for Single Cell Genomics and Epigenomics at the University of Bonn and the German Center for Neurodegenerative Diseases, Bonn, Germany., Beyer M; Molecular Immunology in Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Prinz M; Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg, Germany., Jucker M; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Fischer A; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.; Department for Systems Medicine and Epigenetics in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany., Neher JJ; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany. jonas.neher@dzne.de.; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany. jonas.neher@dzne.de.

Publikováno v: Nature [Nature] 2018 Apr; Vol. 556 (7701), pp. 332-338. Date of Electronic Publication: 2018 Apr 11.

Human VKORC1 mutations cause variable degrees of 4-hydroxycoumarin resistance and affect putative warfarin binding interfaces.

Autor: Czogalla KJ; Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Bonn, Germany., Biswas A, Wendeln AC, Westhofen P, Müller CR, Watzka M, Oldenburg J

Publikováno v: Blood [Blood] 2013 Oct 10; Vol. 122 (15), pp. 2743-50. Date of Electronic Publication: 2013 Aug 27.