Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Wendell W. Weber"'
Publikováno v:
Personalized medicine. 2(3)
Pharmacogenetics represents a rapidly advancing, competitive field of investigation. Due to the potential for clinically recognizable interactions between a set of old polymorphic genes and a relatively new environmental insult (drugs), many human ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df1832e41e606054429057e89c0b0fd3
https://pubmed.ncbi.nlm.nih.gov/29793264
https://pubmed.ncbi.nlm.nih.gov/29793264
Autor:
Wendell W. Weber
Publikováno v:
Molecular Interventions. 10:363-370
Numerous preclinical and clinical trials, with older as well as some newer drugs, have demonstrated the targeting of aberrant epigenetic marks to be a viable means of preventing and treating certain human disorders, including myelodysplastic and leuk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511d5a11ffb8a28ef2704014cbf5048d
https://doi.org/10.1124/mi.10.6.5
https://doi.org/10.1124/mi.10.6.5
Autor:
Wendell W. Weber
Publikováno v:
Clinics in Laboratory Medicine. 28:499-511
Many of the complexities of human drug response are sufficiently well understood to transform the field of pharmacogenetics from a descriptive science to a predictive science. Clinical application of these markers is currently limited by lack of know
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7baf7a0b8eba8760ca0282259e50e3c5
https://doi.org/10.1016/j.cll.2008.05.002
https://doi.org/10.1016/j.cll.2008.05.002
Autor:
Wendell W. Weber
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 479:1-18
Some 40 years of pharmacogenetic research indicates that knowledge of human genetic diversity is essential to a broader understanding of variation in human drug response, and suggests that drug therapy tailored to the genetic characteristics of the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da00d3e2e174f7b51590013547f05d5
https://doi.org/10.1016/s0027-5107(01)00151-8
https://doi.org/10.1016/s0027-5107(01)00151-8
Autor:
Wendell W. Weber
Publikováno v:
Environmental and Molecular Mutagenesis. 37:179-184
Pharmacogenetics is moving rapidly to assemble a large set of polymorphisms that define the influence of genetic diversity on human drug response. Scientific and technological advances of the last 10 years have led to new approaches to the discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81f30918b916849bbfd99a11065bf67
https://doi.org/10.1002/em.1026
https://doi.org/10.1002/em.1026
Autor:
Wendell W. Weber
Publikováno v:
Molecular Diagnosis. 4:299-307
Background : Population frequencies of many polymorphic genes of pharmacogenetic interest depend on race or ethnic specificity. Association of these genes with person-to-person differences in drug effectiveness (hypersensitivity or resistance) and dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31ea4be880e58b316522e94a78990df3
https://doi.org/10.1016/s1084-8592(99)80006-x
https://doi.org/10.1016/s1084-8592(99)80006-x
Publikováno v:
Cancer Letters. 111:39-50
N-Acetyltransferase activity and Michaelis-Menten kinetic constants were determined in cancerous and non-cancerous breast tissues from 30 female patients with breast cancer. The results derived from tissue cytosol showed that 12 rapid, ten intermedia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0be827889aef5c53041e447edf6e517
https://doi.org/10.1016/s0304-3835(96)04491-6
https://doi.org/10.1016/s0304-3835(96)04491-6
Publikováno v:
Biochemical and Biophysical Research Communications. 215:346-354
Prostaglandin endoperoxide H synthase is the key enzyme in the conversion of arachidonic acid to tissue prostanoids. Two isoforms of prostaglandin endoperoxide H synthase have been identified: PHS-1 is constitutively expressed in most tissues under n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4911a04fb78c2f4bd0b52ad018e682f1
https://doi.org/10.1006/bbrc.1995.2472
https://doi.org/10.1006/bbrc.1995.2472
Autor:
Kostas P. Vatsis, Wendell W. Weber, Douglas A. Bell, Jean-Marie Dupret, David A. Price Evans, Denis M. Grant, David W. Hein, Henry J. Lin, Urs A. Meyer, Mary V. Relling, Edith Sim, Tomokazu Suzuki, Yasushi Yamazoe
Publikováno v:
Pharmacogenetics. 5:1-17
A consolidated classification system is described for prokaryotic and eukaryotic N-acetyltransferases in accordance with the international rules for gene nomenclature. The root symbol (NAT) specifically identifies the genes that code for the N-acetyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8929391f7102951348ac93c3777e3f70
https://doi.org/10.1097/00008571-199502000-00001
https://doi.org/10.1097/00008571-199502000-00001
Publikováno v:
Pharmacogenetics. 3:71-76
The increased risk of rapid acetylator humans for the development of colorectal cancer has created interest in experimental animal models to study the relationship of N-acetyltransferase phenotype to colon cancer. Colon cytosols from inbred mouse lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde879b1885e081d5544e8310c9c744a
https://doi.org/10.1097/00008571-199304000-00002
https://doi.org/10.1097/00008571-199304000-00002