Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Wendell P. Davis"'
Autor:
Garvin Warner, Wendell P Davis, Amy Chan, Jessica E. Sutherland, Jason A. Gilbert, Julia Hettinger
Publikováno v:
Nucleic Acid Therapeutics
Revusiran is a 1st-generation short interfering RNA targeting transthyretin conjugated to an N-acetylgalactosamine ligand to facilitate delivery to hepatocytes via uptake by the asialoglycoprotein receptors. Revusiran, in development for the treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e637ef54500d1abd7c76819946102d
http://europepmc.org/articles/PMC6987735
http://europepmc.org/articles/PMC6987735
Autor:
Maja M. Janas, Saeho Chong, Mark K Schlegel, Jason Gilbert, Saket Agarwal, Vasant Jadhav, Dale Gunther, Michelle Jung, Mark Keating, Kelly Wassarman, Shigeo Matsuda, Arlin Rogers, Yongfeng Jiang, Lei Johnson, Elena Castellanos-Rizaldos, Jessica E. Sutherland, Scott Lentini, Urjana Poreci, Klaus Charisse, Jing Li, Anne Kasper, Yesseinia Anglero-Rodriguez, Jeff Rollins, Jing-Tao Wu, Alex Kelin, Sarah Le Blanc Sarah Le Blanc, Diana Cha, Martin E. Maier, Adam Castoreno, Samantha Chigas, Tuyen Nguyen, Muthiah Manoharan, Wendell P Davis, Haiyan Peng, Jayaprakash K. Nair, John Petrulis, Christopher S. Theile, Tyler Chickering, Ivan Zlatev, Tim Racie, Kirk Brown, Christopher R. Brown, Stuart Milstein, Jessica Bombardier, Melissa Mobley, Jeffrey Allen, Raj Maganti, Donald Foster, Kevin Fitzgerald, Jeffrey Kurz, Lauren Blair Woods, Robin McDougall
RNA interference (RNAi) therapeutics are a new class of medicines that can address unmet medical needs by silencing disease-causing gene transcripts. While delivery of short interfering RNAs (siRNAs) to hepatocytes has yielded multiple drug approvals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b912cc876215cb4611322852009dc8f
https://doi.org/10.21203/rs.3.rs-946835/v1
https://doi.org/10.21203/rs.3.rs-946835/v1
Autor:
Krishna Aluri, Laura Sepp-Lorenzino, Christopher R. Brown, Kevin Fitzgerald, Akin Akinc, Martin Maier, Lauren Blair, Peter F Smith, Ju Liu, Jing Li, Ramesh Indrakanti, Biplab Das, Xiumin Liu, Ivan Zlatev, Scott A Barros, Kallanthottathil G. Rajeev, Yongfeng Jiang, Saket Agarwal, Akshay Vaishnaw, Chris Tran, Klaus Charisse, Jingxuan Liu, Muthiah Manoharan, Shigeo Matsuda, Jayaprakash K. Nair, Jessica E. Sutherland, Tracy Zimmermann, Yuanxin Xu, Jing-Tao Wu, Wendell P Davis, Xuemei Zhang, Maja M. Janas, Vasant Jadhav, Mark K Schlegel
Publikováno v:
Nucleic Acids Research
For oligonucleotide therapeutics, chemical modifications of the sugar-phosphate backbone are frequently used to confer drug-like properties. Because 2′-deoxy-2′-fluoro (2′-F) nucleotides are not known to occur naturally, their safety profile wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3324d6db543ac6effbceb9279407203c
https://doi.org/10.1093/nar/gkz140
https://doi.org/10.1093/nar/gkz140
Publikováno v:
Toxicologic pathology. 48(1)
Xenobiotic-induced peripheral nerve damage is a growing concern. Identifying relative risks that a new drug may cause peripheral nerve injury over long periods of administration is gathering importance in the evaluation of animal models. Separating o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7785c025262931ee25db647925b9ae05
https://pubmed.ncbi.nlm.nih.gov/31746699
https://pubmed.ncbi.nlm.nih.gov/31746699
Autor:
Dhruv Desai, Paul Gedman, Zhizhuang Joe Zhao, Ophelia Rogers, Anna Borodovsky, Kellie D'Angelo, Wendell P Davis, Rohan Degaonkar, Donna M. Williams, Alison R. Moliterno, Kristina Yucius, Jerry L. Spivak
Publikováno v:
Blood. 132:4329-4329
The Thrombopoietin (THPO)/ thrombopoietin receptor (MPL) signaling axis is not only critical for the generation of platelets and megakaryocytes, but also for the maintenance of hematopoietic stem cells (HSC) and the bone marrow niche. MPL is expresse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7b9ce8161963c0aaacb941f214dd556
https://doi.org/10.1182/blood-2018-99-117142
https://doi.org/10.1182/blood-2018-99-117142
Autor:
Joseph Loscalzo, Paul L. Huang, Mildred A. Pointer, Geraldine Daumerie, Sadiqa Yancey, LaKeesha Bridges, Wendell P. Davis
Publikováno v:
Hypertension Research. 33:170-176
Hypertension is associated with significant end-organ damage such as stroke, myocardial infarctions, and renal disease. Although endothelial nitric oxide deficient mice (eNOS−/−) are a transgenic model of hypertension, this model has not been stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1961555e9b79a119737c0b1137c3a29
https://doi.org/10.1038/hr.2009.197
https://doi.org/10.1038/hr.2009.197
Autor:
Wan Zhu Jin, Wendell P. Davis, Roger E. Wells, Gen Watanabe, Mohamed S. Medan, Kazuyoshi Taya
Publikováno v:
Journal of Equine Science. 16:45-49
Granulosa-theca cell tumor (GTCT) is the most common ovarian tumor in mares. Two adult Arabian mares presented with a history of persistent estrus (No. 1) and aggressive behavior (No. 2). Large unilateral polycystic ovarian masses were identified in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02058e65863f9b24f7673674c48afdb7
https://doi.org/10.1294/jes.16.45
https://doi.org/10.1294/jes.16.45
Publikováno v:
Journal of Experimental Animal Science. 42:65-83
Summary We characterized atherosclerotic lesions in Syrian F 1 B hamsters fed a diet high in saturated fat and cholesterol. Total cholesterol, non-high-density lipoprotein cholesterol, and triglycerides were significantly higher for treated animals t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fd8453c9adcbe3be3992d0fae385616
https://doi.org/10.1016/s0939-8600(02)80009-8
https://doi.org/10.1016/s0939-8600(02)80009-8
Publikováno v:
Metabolism. 49:826-832
We studied the effects of exercise on high-density lipoprotein (HDL) cholesteryl ester (CE) metabolism in 6 male and 6 female miniature pigs fed a commercial swine diet supplemented with cholesterol and fat. The diets were fed for a total period of 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77cb2dc472279aa0dfc0e0e5ff6ceae7
https://doi.org/10.1053/meta.2000.6746
https://doi.org/10.1053/meta.2000.6746
Publikováno v:
Veterinary Dermatology. 8:139-143
A 1-year-old male miniature donkey (Equus asinus) from a herd of eight was presented with a 9-month history of pruritic dermatitis, lethargy and anorexia. Physical examination revealed diffuse lichenification and scales involving the skin of the face
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fffb4fa873d193a30d59c6655029aa9a
https://doi.org/10.1046/j.1365-3164.1997.d01-1.x
https://doi.org/10.1046/j.1365-3164.1997.d01-1.x