Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Wendell J. Lu"'
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Akademický článek
Regulation of chemokine and chemokine receptor expression by PPARγ in adipocytes and macrophages.
Autor: M T Audrey Nguyen, Ai Chen, Wendell J Lu, Wuqiang Fan, Ping-Ping Li, Da Young Oh, David Patsouris
Publikováno v: PLoS ONE, Vol 7, Iss 4, p e34976 (2012)
PPARγ plays a key role in adipocyte biology, and Rosiglitazone (Rosi), a thiazolidinedione (TZD)/PPARγ agonist, is a potent insulin-sensitizing agent. Recent evidences demonstrate that adipose tissue inflammation links obesity with insulin resistan
Externí odkaz: https://doaj.org/article/9fc5f8ecfe134617af6f502b3817415e
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2
Chylomicron Formation and Secretion is Required for Lipid-Stimulated Release of Incretins GLP-1 and GIP
Autor: Li Yang, David A. D'Alessio, Wendell J. Lu, Dana Lee, Patrick Tso, Qing Yang
Publikováno v: Lipids. 47:571-580
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are incretins produced in the intestine that play a central role in glucose metabolism and insulin secretion. Circulating concentrations of GLP-1 and GIP are low a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53db827a207a586e3018493cfb2e527a
https://doi.org/10.1007/s11745-011-3650-1
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3
GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects
Autor: Wendell J. Lu, WuQiang Fan, Takeshi Imamura, Jerrold M. Olefsky, Da Young Oh, Eun Ju Bae, Hidetaka Morinaga, Pingping Li, Saswata Talukdar, Steven M. Watkins
Publikováno v: Cell. 142:687-698
Omega-3 fatty acids (omega-3 FAs), DHA and EPA, exert anti-inflammatory effects, but the mechanisms are poorly understood. Here, we show that the G protein-coupled receptor 120 (GPR120) functions as an omega-3 FA receptor/sensor. Stimulation of GPR12
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc209069ba82a4989adebf041380297
https://doi.org/10.1016/j.cell.2010.07.041
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4
Using the lymph fistula rat model to study the potentiation of GIP secretion by the ingestion of fat and glucose
Autor: William Sun, Patrick Tso, David A. D'Alessio, Stephen C. Woods, Wendell J. Lu, Qing Yang
Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 294:G1130-G1138
Glucose-dependent insulinotropic polypeptide (GIP) is an important incretin produced in the K cells of the intestine and secreted into the circulating blood following ingestion of carbohydrate- and fat-containing meals. GIP contributes to the regulat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::849d0f2bb0b256650eb021fd1f6c058d
https://doi.org/10.1152/ajpgi.00400.2007
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5
The regulation of the lymphatic secretion of glucagon-like peptide-1 (GLP-1) by intestinal absorption of fat and carbohydrate
Autor: William Sun, Wendell J. Lu, Qing Yang, Stephen C. Woods, Patrick Tso, David A. D'Alessio
Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 293:G963-G971
Glucagon-like peptide-1 (GLP-1) is an important incretin produced in the L cells of the intestine. It is essential in the regulation of insulin secretion and glucose homeostasis. Systemic GLP-1 concentrations are typically low in rodents, so it can b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3459953f0c8677e9834e4c6af0d0384c
https://doi.org/10.1152/ajpgi.00146.2007
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6
Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance
Autor: Pingping Li, Ai Chen, Wendell J. Lu, Mira Ham, Jong In Kim, Min Lu, Jerrold M. Olefsky, In Jae Hwang, Reto A. Schwendener, Guatam K. Bandyopadhyay, Saswata Talukdar, Jae Bum Kim, Jin Young Huh, Yun Sok Lee
Publikováno v: Diabetes
OBJECTIVE Tissue inflammation is a key factor underlying insulin resistance in established obesity. Several models of immuno-compromised mice are protected from obesity-induced insulin resistance. However, it is unanswered whether inflammation trigge
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a51930ee35c9ae3fb514a228a3b19d5a
https://pubmed.ncbi.nlm.nih.gov/21911747
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8
Liver X receptor agonist TO-901317 upregulates SCD1 expression in renal proximal straight tubule
Autor: Jing Wu, Xiaoyan Zhang, Mei-Tsuey Hwang, Wendell J. Lu, Minfen Wei, Linda S. Davis, Guangrui Yang, Lihong Chen, Shuo Li, Dong Ming Su, Matthew D. Breyer, Youfei Guan, Yahua Zhang
Publikováno v: American journal of physiology. Renal physiology. 290(5)
Liver X receptors (LXRs), including LXRα and LXRβ, are intracellular sterol sensors that regulate expression of genes controlling fatty acid and cholesterol absorption, excretion, catabolism, and cellular efflux. Because the kidney plays an importa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80462c52e1e225b83a44213a986bf753
https://pubmed.ncbi.nlm.nih.gov/16368743
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9
Genomic structure and genitourinary expression of mouse cytosolic prostaglandin E(2) synthase gene
Autor: Wendell J. Lu, Matthew D. Breyer, André Schneider, Xuefeng Fan, Reena Rao, Linda S. Davis, Youfei Guan, Richard M. Breyer, Yahua Zhang
Publikováno v: Biochimica et biophysica acta. 1634(1-2)
Prostaglandin E(2) (PGE(2)) plays an important role in genitourinary function. Multiple enzymes are involved in its biosynthesis. Here we report the genomic structure and tissue-selective expression of cytosolic PGE(2) synthase (cPGES) in genitourina
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb88cdeb0422564626977c0e2f36167
https://pubmed.ncbi.nlm.nih.gov/14563409
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10
Regulation of chemokine and chemokine receptor expression by PPARG in adipocytes and macrophages
Autor: Ai Chen, David Patsouris, WuQiang Fan, Pingping Li, MT A Nguyen, Da Young Oh, Wendell J. Lu
Publikováno v: Journal of Translational Medicine
6th european workshop on immune-mediated inflammatory diseases
6th european workshop on immune-mediated inflammatory diseases, Nice, France. pp.P23
6th european workshop on immune-mediated inflammatory diseases, 2011, Nice, France. pp.P23, ⟨10.1186/1479-5876-9-S2-P23⟩
6th european workshop on immune-mediated inflammatory diseases. 2011; 6th european workshop on immune-mediated inflammatory diseases, Nice, FRA, P23
PLoS ONE, Vol 7, Iss 4, p e34976 (2012)
PLoS ONE
Journal of Translational Medicine, Vol 9, Iss Suppl 2, p P23 (2011)
Background PPARγ plays a key role in adipocyte biology, and Rosiglitazone (Rosi), a thiazolidinedione (TZD)/PPARγ agonist, is a potent insulin-sensitizing agent. Recent evidences demonstrate that adipose tissue inflammation links obesity with insul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb294337903cb8df75ebc9fb10f4de2e
http://europepmc.org/articles/PMC3242250
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