Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Wendel W. Doubleday"'
Autor:
Tamar Rosenbaum, Ivy Sabrina E, Fulya Akpinar, Eric M. Saurer, Douglas D. McLeod, Payack Joseph Francis, David A. Conlon, Richard L. Schild, Sloan Ayers, Michael Peddicord, Michelle Soltani, Glenn Ferreira, Joshua Engstrom, Antonio Ramirez, Robert V. Forest, Michelle Haslam, Masano Huang, Deniz Erdemir, Fanfair Dayne Dustan, Alan Braem, Saravanababu Murugesan, Michael S. Bultman, Thomas E. La Cruz, Yande Huang, Charles Pathirana, Stephen Grier, Sapna Shah, Victor W. Rosso, Wei Ding, Jeanne W. Ho, Wendel W. Doubleday, Jonathan Marshall, Whitney Nikitczuk
Publikováno v:
Organic Process Research & Development. 21:1174-1185
This final communication, of a nine part publication series, details the process development history for the final synthetic step to prepare the drug substance BMS-663068 tris(hydroxymethyl)aminomethane (TRIS) salt. The challenge of developing a robu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10868c5e6db4db905e785ee56711ed24
https://doi.org/10.1021/acs.oprd.7b00138
https://doi.org/10.1021/acs.oprd.7b00138
Autor:
Schultz Mitchell J, Payack Joseph Francis, Thomas E. La Cruz, Deniz Erdemir, Peng Geng, Sévrine Broxer, Ivy Sabrina E, Chung-Pin H. Chen, David A. Conlon, Zhongmin Xu, Saravanababu Murugesan, Fanfair Dayne Dustan, Fritz Alan W, Ryan Cullen, Tripp Jonathan Clive, Boguslaw Mudryk, Wendel W. Doubleday, Richard J. Fox
Publikováno v:
Organic Process Research & Development. 21:1095-1109
The development of two enabling routes that led to the production of >1000 kg of BMS-663068 (3) is described. The route identified for the initial 100 kg delivery to support development activities and initial clinical trials involved the conversion o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c87b27b11fba74bca85d3614705da09
https://doi.org/10.1021/acs.oprd.7b00134
https://doi.org/10.1021/acs.oprd.7b00134
Publikováno v:
Organic Process Research & Development. 20:2108-2115
A tricyclopropylamino acid derivative was prepared via Simmons–Smith cyclopropanation of the corresponding alkene. This transformation was plagued by inconsistent conversions, and the opportunity for the removal of the structurally similar alkene c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0280b31771808b2e68862ed634e9a27
https://doi.org/10.1021/acs.oprd.6b00334
https://doi.org/10.1021/acs.oprd.6b00334
Autor:
Wendel W. Doubleday, Srinivas Tummala, Simon Leung, Susanne Kiau, Konstantinos Dambalas, Alaric J. Dyckman, Stephen T. Wrobleski, Luca Parlanti, Ehrlic Lo, Hong Wu, Katerina Leftheris, John Hynes, Paul C. Lobben, Zhongping Shi, Robert P. Discordia
Publikováno v:
Organic Process Research & Development. 16:1618-1625
The development of a practical synthesis for a p38 kinase inhibitor is described. The key advances include an improved route to the key intermediate, a substituted pyrrole, and a subsequent animation utilizing O-(4-nitrobenzoyl)hydroxylamine, which p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::470e0ccba94c380af21b763e40aac735
https://doi.org/10.1021/op300181r
https://doi.org/10.1021/op300181r
Autor:
Mayra B. Reyes, Simon Leung, Zenrong Gao, Theo Denzel, Chiajen Lai, Jack Z. Gougoutas, Mark Lindrud, Kevin J. Volk, Thomas P. Kissick, Victor W. Rosso, Gerard A. Crispino, Wei Meng, Pricilla Richberg, Prashant P. Deshpande, William N. Washburn, Mueller Richard H, David Hughes, Hidegard Lobinger, Renee Randazzo, Peter Hans Ermann, Michael E. Randazzo, Wendel W. Doubleday, Michael Fakes, Annie Pullockaran, Frederic G. Buono, Bruce A. Ellsworth, Janak Singh, John D. Dimarco
Publikováno v:
Organic Process Research & Development. 16:577-585
A practical synthesis of the SGLT-2 inhibitor β-C-aryl-d-glucoside (1) has been developed. The route employed 2,3,4,6-tetra-O-trimethlysilyl-d-glucano-1,5-lactone as the key chiral building block, prepared efficiently from the commercially available
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1fbf64e633a66849c3bae734a3b4e43
https://doi.org/10.1021/op200306q
https://doi.org/10.1021/op200306q
Autor:
Derek Berglund, Jeffrey T. Bien, John Wasylak, Purushotham Vemishetti, David J. Kacsur, Jun Qiu, Oscar W. Haas, Chien-Kuang Chen, Yeung Y. Chan, Carrie A. Costello, Lori Spangler, Emily A. Reiff, Jale Muslehiddinoglu, Dale Vanyo, Stephane Gingras, Jaan A. Pesti, Nina Nguyen, Albert J. DelMonte, John A. Grosso, Chiajen Lai, Simon Leung, Wendel W. Doubleday, Michael J. Totleben, Paul Demena, Elisabeth Corbett, Martina Olzog, Dominique Thoraval, Serge Benoit, Melanie Miller, Robert P. Discordia, Zhinong Gao, Paul R. Brodfuehrer, Chenkou Wei
Publikováno v:
Organic Process Research & Development. 13:716-728
The development of a safe, robust process for the preparation of ravuconazole (1), an antifungal agent, is described. The discovery and development of procedures enabling the efficient synthesis of multikilogram quantities of 1 and the process demons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efd3df18d5b9bf645964394a96c66206
https://doi.org/10.1021/op900065c
https://doi.org/10.1021/op900065c
Autor:
Akin H. Davulcu, Kishta Katipally, Adam Littke, Mark D. Schwinden, Cary W. McConlogue, Rodney L. Parsons, Zhongmin Xu, Chiajen J. Lai, Gleeson Margaret M, Douglas D. McLeod, Jun Li, Wendel W. Doubleday
Publikováno v:
The Journal of Organic Chemistry. 74:4068-4079
BMS-317180 (1) is a potent, orally active agonist of the human growth hormone secretagogue (GHS) receptor. This manuscript details the process research and development efforts that enabled the synthesis of the phosphate salt of 1 on a multi-kilogram
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f470433a57036e874d66fe230f72bb6f
https://doi.org/10.1021/jo9003508
https://doi.org/10.1021/jo9003508
Autor:
Pierre-Jean Colson, Wendel W. Doubleday, Joseph E. Duran, Payman N. Farid, Alok K. Awasthi, Mark L. Boys, Kimberly J. Cain-Janicki
Publikováno v:
The Journal of Organic Chemistry. 70:5387-5397
[reaction: see text] A practical, large-scale synthesis of a beta-amino ester 1 was developed. A chiral imine derived from (S)-phenylglycinol and 3-trimethylsilylpropanal was coupled with the Reformatsky reagent 3 with high diastereoselectivity (de98
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5731a0d8a88d98157df816a1b5c1084d
https://doi.org/10.1021/jo050177h
https://doi.org/10.1021/jo050177h
Autor:
Wendel W. Doubleday, and James R. Behling, Mark L. Boys, Kimberly J. Cain-Janicki, Payman Farid, Pilipauskas Daniel R, Mangalya Kar, Sean T. Nugent
Publikováno v:
Organic Process Research & Development. 1:233-239
The large-scale preparation of the β-alkynyl β-amino acid ester (±)-1,1-dimethylethyl 3-amino-5-(trimethylsilyl)-4-pentynoate (A) is discussed. It was discovered that addition of a catalytic amount of lithium bis(trimethylsilyl)amide (LHMDS) to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bde4013f59ddff4ac52e9e01c724a0f
https://doi.org/10.1021/op970102i
https://doi.org/10.1021/op970102i
Publikováno v:
Synthetic Communications. 25:33-41
The reaction of allylmanganese(II) reagents with aldehydes gives alcohols with high regioselectivity. The allylmanganese(II) reagents are prepared by transmetallation between manganese(II) chloride and allyllithium compounds which are generated from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d99404d1be118ccbd9a868f4e1d16267
https://doi.org/10.1080/00397919508010786
https://doi.org/10.1080/00397919508010786