Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Wenda C. Carlyle"'
Autor:
Lynn Bailey, John Keating, Wenda C. Carlyle, Josep-Maria Balaguer, Timothy Charles Kiorpes, Fernando Garcia-Polite, Brett G. Zani, Xiaojian Li, Abraham R. Tzafriri, Elazer R. Edelman, Peter Markham
Publikováno v:
PMC
Background: Innovations in drug eluting stent designs make it increasingly important to develop models for differentiating performance through spatial definition of drug, receptor binding and cell state. Methods: Two designs of sirolimus analog eluti
Autor:
Robin P. Kraak, Jeffrey G. Mifek, Wenda C. Carlyle, Karel T. Koch, Joanna J. Wykrzykowska, Robbert J. de Winter, Huangling Lu, Dennis Donohoe, Ruben Y.G. Tijssen
Publikováno v:
Expert review of medical devices, 14(5), 325-334. Taylor and Francis Ltd.
Treatment of coronary artery disease has made strides over the last decades. Development of drug eluting stents (DES), coated with a polymer layer and an anti-proliferative drug to reduce neointimal hyperplasia, has reduced the incidence of in-stent-
Publikováno v:
Minerva cardioangiologica. 64(5)
Drug-eluting stents (DES) have dramatically improved the long-term efficacy of percutaneous coronary intervention (PCI). Over the last decade there have been numerous advances in DES platforms, however, all but one currently approved DES in the Unite
Autor:
Peter Markham, Lynn Bailey, James R. L. Stanley, Brett G. Zani, Wenda C. Carlyle, Elazer R. Edelman, Abraham R. Tzafriri, James B. Mcclain
Publikováno v:
Elsevier
Current drug eluting stent (DES) technology is not optimized with regard to the pharmacokinetics of drug delivery. A novel, absorbable-coating sirolimus-eluting stent (AC-SES) was evaluated for its capacity to deliver drug more evenly within the inti
Autor:
Wenda C. Carlyle, Yi Zhang, Guangrong Gong, Jianyi Zhang, Marcel H.J. Eijgelshoven, Wei Chen, Robert J. Bache, Yo Murakami
Publikováno v:
Scopus-Elsevier
This study examined whether alterations in myocardial creatine kinase (CK) kinetics and high-energy phosphate (HEP) levels occur in postinfarction left ventricular remodeling (LVR). Myocardial HEP and CK kinetics were examined in 19 pigs 6 wk after m
Autor:
Jay N. Cohn, Gary S. Francis, Malinda M. Hartman, Cuixia Chu, Wenda C. Carlyle, Dianne L. Judd, Katherine M. Hauer, Kenneth McDonald
Publikováno v:
Journal of Molecular and Cellular Cardiology. 29:3203-3210
The effectiveness of angiotensin-converting enzyme (ACE)-inhibitor therapy in attenuating ventricular remodeling when initiated immediately following myocardial damage is clearly established. Less information, however, is available on the impact of l
Autor:
Bin Tian, Katherine M. Hauer, Cuixia Chu, Dianne L. Judd, Andrew Jacobson, Malinda M. Hartman, Wenda C. Carlyle, Kenneth McDonald
Publikováno v:
Journal of Molecular and Cellular Cardiology. 29:2451-2463
Delayed reperfusion has a beneficial effect on prognosis, independent of infarct size. One potential mechanism to explain this observation may be an effect on infarct healing. In this study, the impact of delayed reperfusion on two aspects of the hea
Autor:
Jay N. Cohn, Cynthia Toher, Dianne L. Judd, W.Guy Weigold, Wenda C. Carlyle, Kenneth McDonald, Bin Tian, D. C. Homans
Publikováno v:
Journal of molecular and cellular cardiology. 31(4)
Beta-actin is a cytoskeletal protein that has been implicated as a potentially important mediator of the growth, signaling, migration, and remodeling of cells. Beta-actin is upregulated in remodeling myocardium in response to either pressure or volum
Autor:
Jay N. Cohn, Jonathan R. Vandervelde, Cynthia Toher, Wenda C. Carlyle, D. C. Homans, Kenneth McDonald
Publikováno v:
Journal of molecular and cellular cardiology. 28(1)
Beta-actin, a cytoskeletal protein important in the maintenance of cytoarchitecture, has long been thought to be expressed constitutively in myocardial tissue. As such, beta-actin mRNA has been used as a control gene in a wide range of experiments. H
Autor:
Peter Markham, Abraham R. Tzafriri, Brett Zani, James B. Mcclain, James C. Stanley, Wenda C. Carlyle, Lynn Bailey, Elazer R. Edelman
Publikováno v:
Journal of the American College of Cardiology. 60:B166
We examined whether deployment of coating from drug-eluting stents (DES) into surrounding neointima could protect a crystalline drug load from luminal washout and distribute drug more efficiently and uniformly compared to conventional DES. Sirolimus