Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Wenan, Chen"'
Autor:
Kohei Yamada, Jaivardhan A. Menon, Yaunghyun Kim, Changde Cheng, Wenan Chen, Jenny A. Shih, Ana B. Villasenor-Altamirano, Xiang Chen, Tomoyoshi Tamura, Louis T. Merriam, Edy Y. Kim, Alexandra J. Weissman
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102874- (2024)
Summary: Immunophenotyping of out-of-hospital cardiac arrest (OHCA) patients is of increasing interest but has challenges. Here, we describe steps for the design of the clinical cohort, planning patient enrollment and sample collection, and ethical r
Externí odkaz:
https://doaj.org/article/a33b1ff513a643bf841618340b656c10
Autor:
Jie Fang, Shivendra Singh, Changde Cheng, Sivaraman Natarajan, Heather Sheppard, Ahmed Abu-Zaid, Adam D. Durbin, Ha Won Lee, Qiong Wu, Jacob Steele, Jon P. Connelly, Hongjian Jin, Wenan Chen, Yiping Fan, Shondra M. Pruett-Miller, Jerold E. Rehg, Selene C. Koo, Teresa Santiago, Joseph Emmons, Stefano Cairo, Ruoning Wang, Evan S. Glazer, Andrew J. Murphy, Taosheng Chen, Andrew M. Davidoff, Carolina Armengol, John Easton, Xiang Chen, Jun Yang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-27 (2023)
Abstract A lack of relevant genetic models and cell lines hampers our understanding of hepatoblastoma pathogenesis and the development of new therapies for this neoplasm. Here, we report an improved MYC-driven hepatoblastoma-like murine model that re
Externí odkaz:
https://doaj.org/article/518df2bf603d4dbaa5922a65b63e4a51
Autor:
Richa Sharma, Ninad Oak, Wenan Chen, Rose Gogal, Martin Kirschner, Fabian Beier, Michael J. Schnieders, Maria Spies, Kim E. Nichols, Marcin Wlodarski
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Replication Protein A (RPA) is single-strand DNA binding protein that plays a key role in the replication and repair of DNA. RPA is a heterotrimer made of 3 subunits – RPA1, RPA2, and RPA3. Germline pathogenic variants affecting RPA1 were recently
Externí odkaz:
https://doaj.org/article/6debf3fe1a934daa9d9e6c9b603efdd3
Publikováno v:
Unconventional Resources, Vol 3, Iss , Pp 183-191 (2023)
Experiments on the dynamic and static elastic parameters under distinct loading conditions help clarify the effects of loading rate and strain amplitude on dynamic and static elastic moduli, and gain further insight into the moduli. Significant scien
Externí odkaz:
https://doaj.org/article/a889fe50606748469417c4451bf78726
Autor:
Carolin Escherich, Wenan Chen, Wenjian Yang, David T. Teachey, Elizabeth A. Raetz, Meenakshi Devidas, Gang Wu, Kim E. Nichols, Hiroto Inaba, Ching-Hon Pui, Sima Jeha, Stephen P. Hunger, Mignon L. Loh, Jun J. Yang
Publikováno v:
HemaSphere, Vol 7, p e4470514 (2023)
Externí odkaz:
https://doaj.org/article/5e2dd0cd40d948078d5edb03d94e5a96
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Sequencing studies in clinical and cancer genomics often utilize public data sets to identify genes enriched with pathogenic variants. Here, the authors propose a framework which controls for confounding factors that can bias the results in these stu
Externí odkaz:
https://doaj.org/article/8e91bfbc19864239a7e17d54140bb06e
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Causal variants for rare genetic diseases are often rare in the general population. Rare variants may also contribute to common complex traits and can have much larger per-allele effect sizes than common variants, although power to detect these assoc
Externí odkaz:
https://doaj.org/article/1d9426eae2d5484c857319a827a32fd6
Publikováno v:
Cells, Vol 12, Iss 15, p 1970 (2023)
Single-cell RNA sequencing (scRNA-seq) has emerged as a powerful tool for investigating cellular biology at an unprecedented resolution, enabling the characterization of cellular heterogeneity, identification of rare but significant cell types, and e
Externí odkaz:
https://doaj.org/article/19323dbadd9f4301a32c548974024b7e
Autor:
Katerina Placek, Michael Benatar, Joanne Wuu, Evadnie Rampersaud, Laura Hennessy, Vivianna M Van Deerlin, Murray Grossman, David J Irwin, Lauren Elman, Leo McCluskey, Colin Quinn, Volkan Granit, Jeffrey M Statland, Ted M Burns, John Ravits, Andrea Swenson, Jon Katz, Erik P Pioro, Carlayne Jackson, James Caress, Yuen So, Samuel Maiser, David Walk, Edward B Lee, John Q Trojanowski, Philip Cook, James Gee, Jin Sha, Adam C Naj, Rosa Rademakers, The CReATe Consortium, Wenan Chen, Gang Wu, J Paul Taylor, Corey T McMillan
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 1, Pp 1-18 (2020)
Abstract Amyotrophic lateral sclerosis (ALS) is a multi‐system disease characterized primarily by progressive muscle weakness. Cognitive dysfunction is commonly observed in patients; however, factors influencing risk for cognitive dysfunction remai
Externí odkaz:
https://doaj.org/article/c97ccf4df05c438e987a0ef12c4302e4
Autor:
Wenan Chen, Silu Zhang, Justin Williams, Bensheng Ju, Bridget Shaner, John Easton, Gang Wu, Xiang Chen
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 861-873 (2020)
Accounting for batch effects, especially latent batch effects, in differential expression (DE) analysis is critical for identifying true biological effects. Single-cell RNA sequencing (scRNA-seq) is a powerful tool for quantifying cell-to-cell variat
Externí odkaz:
https://doaj.org/article/f6ecb90168db4ce7937abdc5a6e9ea20