Zobrazeno 1 - 10
of 24
pro vyhledávání: '"WenLian Xu"'
Autor:
Krisna C Duong-Ly, Hyun Nyun Woo, Christopher A Dunn, WenLian Xu, Andrej Babič, Maurice J Bessman, L Mario Amzel, Sandra B Gabelli
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64241 (2013)
The gene for a Nudix enzyme (SP_1669) was found to code for a UDP-X diphosphatase. The SP_1669 gene is localized among genes encoding proteins that participate in cell division in Streptococcus pneumoniae. One of these genes, MurF, encodes an enzyme
Externí odkaz:
https://doaj.org/article/b687255e82034ddba3d3e7e239bce26c
Autor:
Shilin Xue, Wenlian Xu, Ni Lu, Ruiping Dong, Danming Zhu, Toshio Shimizu, Meng Fu, Pilin Wang, Takako Eguchi Nakajima, Xiaoxiao Wang, Ting Xu, Haolan Lu, John Gong, Walt Cao, David T.L. Liu
Publikováno v:
Journal of Clinical Oncology. 37:2609-2609
2609 Background: KN035 is a novel fusion protein of humanized anti-PD-L1 single domain antibody and human IgG1 Fc, formulated for subcutaneous (SC) injection. A phase I safety and pharmacokinetic (PK) study was conducted in Japanese patients. Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca45bedaac0843ec98cc878ba3a600b8
https://doi.org/10.1200/jco.2019.37.15_suppl.2609
https://doi.org/10.1200/jco.2019.37.15_suppl.2609
Autor:
Ruiping Dong, Yun Zhang, Huilong Liu, John Gong, David T.L. Liu, Rongrui Liu, Walt Cao, Shukui Qin, Chuanhua Zhao, Yaoyue Zhang, Meng Fu, Gairong Zhang, Jianming Xu, Pilin Wang, Ni Lu, Xiaoxiao Wang, Haolan Lu, Wenlian Xu, Ru Jia, Ting Xu
Publikováno v:
Journal of Clinical Oncology. 37:2608-2608
2608 Background: KN035 is a novel fusion protein of humanized anti-PD-L1 single domain antibody and human IgG1 Fc fragment, formulated for subcutaneous (SC) injection. Methods: The escalation phase followed a modified 3+3 design with a 28-day DLT eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05a08bc896192f289af649adf4813f6b
https://doi.org/10.1200/jco.2019.37.15_suppl.2608
https://doi.org/10.1200/jco.2019.37.15_suppl.2608
Autor:
Archana Pannuri, Tony Romeo, Maurice J. Bessman, Sandra B. Gabelli, WenLian Xu, Agedi N. Boto, L. Mario Amzel, Jean Jakoncic
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 79:2455-2466
The Nudix hydrolase superfamily, characterized by the presence of the signature sequence GX(5)EX(7)REUXEEXGU (where U is I, L, or V), is a well-studied family in which relations have been established between primary sequence and substrate specificity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73f125fe67545c46db2912f286a57462
https://doi.org/10.1002/prot.23069
https://doi.org/10.1002/prot.23069
Autor:
Xiaoxiao Wang, Ni Lu, Gairong Zhang, Pilin Wang, Lin Yihui, Wenlian Xu, Yaoyue Zhang, Xiaoyu Ma, Chuanhua Zhao, Rongrui Liu, Ruiping Dong, Yun Zhang, Shukui Qin, Jianming Xu, Ting Xu, Liwei Yuan, Ru Jia, John Gong, Yan Wang, Yue He
Publikováno v:
Journal of Clinical Oncology. 36:e15138-e15138
e15138Background: KN035 is a novel programmed death-ligand 1(PD-L1) antagonist and formulated to high protein concentration (200 mg/ml) and provided as a transparent liquid solution for subcutaneou...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0eefee5a7b5b15bed84600e95ddd347f
https://doi.org/10.1200/jco.2018.36.15_suppl.e15138
https://doi.org/10.1200/jco.2018.36.15_suppl.e15138
Publikováno v:
Dyes and Pigments. 77:125-128
Several novel, diarylamine-substituted 1,8-naphthalimide derivatives were synthesized and characterized by FT-IR, 1 H, 13 C NMR, mass spectra and elemental analyses. The asymmetry inherent in the compounds prevented them from crystallizing and high t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::364161ecdabcfe45b47c7de97a4775f1
https://doi.org/10.1016/j.dyepig.2007.03.017
https://doi.org/10.1016/j.dyepig.2007.03.017
Publikováno v:
Journal of Bacteriology. 186:8380-8384
Gene ytkD of Bacillus subtilis , a member of the Nudix hydrolase superfamily, has been cloned and expressed in Escherichia coli . The purified protein has been characterized as a nucleoside triphosphatase active on all of the canonical ribo- and deox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4951d48ef40c42ba22286e515eaf0a4a
https://doi.org/10.1128/jb.186.24.8380-8384.2004
https://doi.org/10.1128/jb.186.24.8380-8384.2004
Publikováno v:
Journal of Biological Chemistry. 279:24861-24865
The genome of Bacillus cereus contains 26 Nudix hydrolase genes, second only to its closest relative, Bacillus anthracis which has 30. All 26 genes have been cloned, 25 have been expressed, and 21 produced soluble proteins suitable for analysis. Subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea50b7b7564db78baa0b47168703b336
https://doi.org/10.1074/jbc.m403272200
https://doi.org/10.1074/jbc.m403272200
Autor:
Elizabeth L. Holbrook, Ursula Schulze-Gahmen, Maurice J. Bessman, WenLian Xu, Stephen R. Holbrook, Wasantha Ranatunga, Emma Hill, Jana L. Mooster, Steven E. Brenner
Publikováno v:
Journal of Molecular Biology. 339:103-116
We have determined the crystal structure, at 1.4 A, of the Nudix hydrolase DR1025 from the extremely radiation resistant bacterium Deinococcus radiodurans. The protein forms an intertwined homodimer by exchanging N-terminal segments between chains. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64065aa1c28a2492b90438e85e10d999
https://doi.org/10.1016/j.jmb.2004.01.065
https://doi.org/10.1016/j.jmb.2004.01.065
Publikováno v:
Journal of Biological Chemistry. 278:37492-37496
A new subfamily of the Nudix hydrolases, identified by conserved amino acids upstream and downstream of the Nudix box, has been characterized. The cloned, expressed, and purified orthologous enzymes have major activities on the non-canonical nucleosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4b7ae189134720a21d71a874d5a0dc8
https://doi.org/10.1074/jbc.m307639200
https://doi.org/10.1074/jbc.m307639200