Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Wen-wen Qin"'
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Akademický článek
Evaluation of circulating small extracellular vesicle-derived miRNAs as diagnostic biomarkers for differentiating between different pathological types of early lung cancer
Autor: Yi-fang Jiang, Shan-na Wei, Nan Geng, Wen-wen Qin, Xin He, Xiu-huan Wang, Yao-pu Qi, Shan Song, Ping Wang
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Lung cancer is the leading cause of cancer-related death worldwide. MicroRNAs (miRNAs) in circulating small extracellular vesicles (sEVs) have been suggested to be potential biomarkers for cancer diagnosis. The present study was designed to
Externí odkaz: https://doaj.org/article/6740861ababe40e0bba2abec9739d993
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Synthesis and identification of 2,4-bisanilinopyrimidines bearing 2,2,6,6-tetramethylpiperidine-N-oxyl as potential Aurora A inhibitors
Autor: Yu Xu, You-Zhen Ma, Xing-Rong Wang, Shi-Wu Chen, Chun-Yan Sang, Ling Hui, Xiu-Juan Zhang, Wen-Wen Qin
Publikováno v: Bioorganicmedicinal chemistry. 27(1)
The Aurora kinases are a family of serine/threonine kinases that interact with components of the mitotic apparatus and serve as potential therapeutic targets in oncology. Herein, we reported a series of 2,4-bisanilinopyrimidines bearing 2,2,6,6-tetra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d125e3b96c042328f1ac7e8acc1f1bb3
https://pubmed.ncbi.nlm.nih.gov/30502115
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5
Over-regulation of microRNA-133b inhibits cell proliferation of cisplatin-induced non-small cell lung cancer cells through PI3K/Akt and JAK2/STAT3 signaling pathway by targeting EGFR
Autor: Nan Geng, Yan-Xiao Li, Wen-Wen Qin, Bin Li, Jing-Cui Peng, Cui-Min Ding
Publikováno v: Oncology Reports.
The present study determined the anticancer activity and its mechanism of microRNA‑133b on cell proliferation of cisplatin-induced non-small cell lung cancer cells. The expression of microRNA-133b cisplatin‑induced non-small cell lung cancer (NSC
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ec2b55ec29832674b7937563176525
https://doi.org/10.3892/or.2018.6215
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6
Bilevel Programming Model for City Logistics Distribution Optimization under Time Restriction Caused by Traffic Organization
Autor: Xiaofeng Ji, Fei-wen Liang, Yong-ming Pu, Wen-wen Qin
Publikováno v: Journal of Highway and Transportation Research and Development (English Edition). 9:94-101
For the optimization of city logistics distribution under time restriction caused by traffic organization, a bilevel programming model considering the distribution cost, environment cost, and distribution time of enterprises is developed. The primary
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::605c20acb11304ddca222a26e107ac7a
https://doi.org/10.1061/jhtrcq.0000462
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7
MicroRNA‑145 inhibits migration and induces apoptosis in human non‑small cell lung cancer cells through regulation of the EGFR/PI3K/AKT signaling pathway
Autor: Bin Li, Wen‑Wen Qin, Nan Geng, Yan‑Xiao Li, Cui‑Min Ding, Jing‑Cui Peng
Publikováno v: Oncology reports. 40(5)
In the present study, the therapeutic effects and the underlying molecular mechanisms of microRNA (miR)‑145 were investigated in non‑small cell lung cancer (NSCLC) cells. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90bff049b9cb1a6549dc5a7e958c048c
https://pubmed.ncbi.nlm.nih.gov/30226581
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8
DPMA, a deoxypodophyllotoxin derivative, induces apoptosis and anti-angiogenesis in non-small cell lung cancer A549 cells
Autor: Xiao-Hui Xu, Shi-Wu Chen, Chun-Yan Sang, Lin Hui, Jian-Fei Liu, Wen-Wen Qin
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 23:6650-6655
We found that the deoxypodophyllotoxin derivative, 2,6-dimethoxy-4-(6-oxo-(5R,5aR,6,8,8aR,9-hexahydrofuro[3′,4′:6,7]naphtho[2,3-d][1,3]dioxol-5-yl)phenyl ((R)-1-amino-4-(methylthio)-1-oxobutan-2-yl)carbamate (DPMA), exhibited superior cytotoxicit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbccc21d8260175a521c75deffcd3810
https://doi.org/10.1016/j.bmcl.2013.10.048
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9
Synthesis and evaluation of the apoptosis inducing and CT DNA interaction properties of a series of 4β-carbamoyl 4′-O-demethylepipodophyllotoxins
Autor: Yong-Xin Jin, Wen-Wen Qin, Chun-Yan Sang, Lin Hui, Shi-Wu Chen, Jian-Fei Liu, Jie Zhao
Publikováno v: European Journal of Medicinal Chemistry. 70:59-67
A series of carbamate derivatives of 4'-demethylepipodophyllotoxin have been synthesized, and their cytotoxicities against several human cancer cell lines, including HeLa, A549, HCT-8, and HL-60 cells, evaluated. Some of these compounds exhibited hig
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb599b71efeaec3d3aaf70728c7c9e3
https://doi.org/10.1016/j.ejmech.2013.09.053
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10
Synthesis and evaluation of the cell cycle arrest and CT DNA interaction properties of 4β-amino-4′-O-demethyl-4-deoxypodophyllotoxins
Autor: Jie Zhao, Shi-Wu Chen, Wen-Wen Qin, Yi-Lan Ding, Chun-Yan Sang, Lin Hui, Jian-Fei Liu
Publikováno v: Bioorganic & Medicinal Chemistry. 21:6948-6955
A series of 4β-amino-4′- O -demethyl-4-deoxypodophyllotoxin derivatives were synthesized, and their cytotoxicities against several human cancer cell lines, including HepG2, A549, HeLa and HCT-8 cells, evaluated. Some of these compounds exhibited h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1e0c6d113186f3b4f15b73a43ed21c
https://doi.org/10.1016/j.bmc.2013.09.026
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