Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Wen-ning Zhao"'
Autor:
Wen-Ning Zhao, Brian T. D. Tobe, Namrata D. Udeshi, Lucius L. Xuan, Cameron D. Pernia, Daniel P. Zolg, Amanda J. Roberts, Deepak Mani, Sarah R. Blumenthal, Iren Kurtser, Debasis Patnaik, Irina Gaisina, Joshua Bishop, Steven D. Sheridan, Jasmin Lalonde, Steven A. Carr, Evan Y. Snyder, Stephen J. Haggarty
Publikováno v:
Translational Psychiatry, Vol 10, Iss 1, Pp 1-18 (2020)
Abstract The effective treatment of bipolar disorder (BD) represents a significant unmet medical need. Although lithium remains a mainstay of treatment for BD, limited knowledge regarding how it modulates affective behavior has proven an obstacle to
Externí odkaz:
https://doaj.org/article/3adcd41d1c9642cb98771f72e34b370f
Autor:
Xudong Lin, Xin Duan, Claire Jacobs, Jeremy Ullmann, Chung-Yuen Chan, Siya Chen, Shuk-Han Cheng, Wen-Ning Zhao, Annapurna Poduri, Xin Wang, Stephen J. Haggarty, Peng Shi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
A major goal in neuropharmacology is to develop new tools to effectively test the therapeutic potential of pharmacological agents to treat neurological and psychiatric conditions. Here, authors present an in vivo drug screening system that generates
Externí odkaz:
https://doaj.org/article/709f8352b59f4f82a66f22e89e4f510e
Autor:
Jasmin Lalonde, Surya A. Reis, Sudhir Sivakumaran, Carl S. Holland, Hendrik Wesseling, John F. Sauld, Begum Alural, Wen-Ning Zhao, Judith A. Steen, Stephen J. Haggarty
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
The activity-regulated cytoskeleton-associated protein (Arc) has been implicated in synaptic plasticity and memory consolidation. Here the authors show that Arc acetylation regulates its stability and identify small molecules that modulate Arc expres
Externí odkaz:
https://doaj.org/article/5ddba3c2cdb2426a93470cf04103e35c
Autor:
Martin G. Strebl, Arthur J. Campbell, Wen-Ning Zhao, Frederick A. Schroeder, Misha M. Riley, Peter S. Chindavong, Thomas M. Morin, Stephen J. Haggarty, Florence F. Wagner, Tobias Ritter, Jacob M. Hooker
Publikováno v:
ACS Central Science, Vol 3, Iss 9, Pp 1006-1014 (2017)
Externí odkaz:
https://doaj.org/article/37d35a7fa07b46fa9e8e5ab78a51f0b0
Autor:
Synodos for NF2 Consortium, Robert Allaway, Steve P Angus, Roberta L Beauchamp, Jaishri O Blakeley, Marga Bott, Sarah S Burns, Annemarie Carlstedt, Long-Sheng Chang, Xin Chen, D Wade Clapp, Patrick A Desouza, Serkan Erdin, Cristina Fernandez-Valle, Justin Guinney, James F Gusella, Stephen J Haggarty, Gary L Johnson, Salvatore La Rosa, Helen Morrison, Alejandra M Petrilli, Scott R Plotkin, Abhishek Pratap, Vijaya Ramesh, Noah Sciaky, Anat Stemmer-Rachamimov, Tim J Stuhlmiller, Michael E Talkowski, D Bradley Welling, Charles W Yates, Jon S Zawistowski, Wen-Ning Zhao
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0197350 (2018)
Neurofibromatosis 2 (NF2) is a rare tumor suppressor syndrome that manifests with multiple schwannomas and meningiomas. There are no effective drug therapies for these benign tumors and conventional therapies have limited efficacy. Various model syst
Externí odkaz:
https://doaj.org/article/9827869b05b5455bb1789d9f8c1987f8
Autor:
Frederick A Schroeder, Michael C Lewis, Daniel M Fass, Florence F Wagner, Yan-Ling Zhang, Krista M Hennig, Jennifer Gale, Wen-Ning Zhao, Surya Reis, Douglas D Barker, Erin Berry-Scott, Sung Won Kim, Elizabeth L Clore, Jacob M Hooker, Edward B Holson, Stephen J Haggarty, Tracey L Petryshen
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71323 (2013)
Psychiatric diseases, including schizophrenia, bipolar disorder and major depression, are projected to lead global disease burden within the next decade. Pharmacotherapy, the primary--albeit often ineffective--treatment method, has remained largely u
Externí odkaz:
https://doaj.org/article/f98bfbbf4c0c4abda75478a1de4329d5
Autor:
Ashwani Kumar, Galina Aglyamova, Yun Young Yim, Aaron O Bailey, Haley M Lynch, Reid T Powell, Nghi D Nguyen, Zachary Rosenthal, Wen-Ning Zhao, Yi Li, Jianping Chen, Shanghua Fan, Hubert Lee, William K Russell, Clifford Stephan, Alfred J Robison, Stephen J Haggarty, Eric J Nestler, Jia Zhou, Mischa Machius, Gabby Rudenko
Publikováno v:
Nucleic acids research. 50(16)
The AP1 transcription factor ΔFOSB, a splice variant of FOSB, accumulates in the brain in response to chronic insults such as exposure to drugs of abuse, depression, Alzheimer's disease and tardive dyskinesias, and mediates subsequent long-term neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28fc59d86aaf25f7d96823a3e2e4dc06
https://pubmed.ncbi.nlm.nih.gov/36039764
https://pubmed.ncbi.nlm.nih.gov/36039764
Autor:
Ping-Chieh Pao, Stephen J. Haggarty, Ling Pan, Li-Huei Tsai, Wen-Ning Zhao, Peter S. Chindavong, Debasis Patnaik, Norma K. Hylton, M. Catarina Silva
Publikováno v:
ACS Chemical Neuroscience. 12:271-284
Genomic instability caused by a deficiency in the DNA damage response and repair has been linked to age-related cognitive decline and neurodegenerative diseases. Preventing genomic instability that ultimately leads to neuronal death may provide a bro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9140b3c8a67f521f933c9474f11d3ca3
https://doi.org/10.1021/acschemneuro.0c00308
https://doi.org/10.1021/acschemneuro.0c00308
Autor:
Jennifer P. Wang, Steven D. Sheridan, Isaac S. Kohane, Matthew B. A. McDermott, Peter Szolovits, Stephen J. Haggarty, Roy H. Perlis, Wen-Ning Zhao
Publikováno v:
IEEE/ACM Trans Comput Biol Bioinform
Gene expression data can offer deep, physiological insights beyond the static coding of the genome alone. We believe that realizing this potential requires specialized, high-capacity machine learning methods capable of using underlying biological str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93005d5d878b1714d12e4c14b887d19a
https://doi.org/10.1109/tcbb.2019.2910061
https://doi.org/10.1109/tcbb.2019.2910061
Autor:
Peter J. H. Scott, Debasis Patnaik, Xia Shao, Lucius L Xuan, Nicolas Salem, Phillip S. Sherman, Surya A. Reis, Ashley C Knight, Andrew V. Mossine, Jenelle Stauff, Shil Patel, Peter S. Chindavong, Lisa Wells, David R. Bonsall, Neil Vasdev, Jinshan Michael Chen, Stephen J. Haggarty, Ravi G. Kurumbail, Janna Arteaga, Wen-Ning Zhao, Chialin Cheng, Laurent Martarello, Steven H. Liang, Vadim Bernard-Gauthier, Brenda Amaral, Hema S. Krishnan, Cassis Varlow
Publikováno v:
Journal of Medicinal Chemistry. 62:9600-9617
Using structure-guided design, several cell based assays, and microdosed positron emission tomography (PET) imaging, we identified a series of highly potent, selective, and brain-penetrant oxazole-4-carboxamide-based inhibitors of glycogen synthase k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6f19c69be22ace49ff49e06bec2585
https://doi.org/10.1021/acs.jmedchem.9b01030
https://doi.org/10.1021/acs.jmedchem.9b01030