Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Wen-ling Dai"'
Publikováno v:
Linchuang shenzangbing zazhi, Vol 24, Iss 2, Pp 155-159 (2024)
Diabetic kidney disease (DKD) is a disease of abnormal renal structure and function due to long-term hyperglycemia. Podocyte injury is a major cause of renal inflammation, glomerular filtration barrier injury and renal fibrosis. Ubiquitin proteasome
Externí odkaz:
https://doaj.org/article/565a0c77ec974c5ea986097958bb7376
Autor:
Wen-Ling Dai, Yi-Ni Bao, Ji-Fa Fan, Bin Ma, Shan-Shan Li, Wan-Li Zhao, Bo-Yang Yu, Ji-Hua Liu
Publikováno v:
Journal of Advanced Research, Vol 28, Iss , Pp 139-148 (2021)
Introduction: Spinal N-methyl-D-aspartate receptor (NMDAR) is vital in chronic pain, while NMDAR antagonists have severe side effects. NMDAR has been reported to be controlled by G protein coupled receptors (GPCRs), which might present new therapeuti
Externí odkaz:
https://doaj.org/article/c0ac096b476046a196d81f11b30cec65
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-13 (2020)
Abstract Background Anti-nerve growth factor (NGF) monoclonal antibodies (anti-NGF mAbs) have been reported to significantly attenuate pain, but the mechanism involved has not been fully elucidated, and the serious adverse events associated with mAbs
Externí odkaz:
https://doaj.org/article/474cac35dfa047c4a3936fc6cbc18141
Publikováno v:
Experimental and Molecular Medicine, Vol 50, Iss 11, Pp 1-12 (2018)
Pain medicine: why blocking dopamine receptors alleviates morphine tolerance By blocking dopamine receptors located in the spinal cord, a compound found in a traditional Chinese herbal medicine may help mitigate tolerance to morphine, a common proble
Externí odkaz:
https://doaj.org/article/0984000056eb4eeeb931630ce935eb51
Publikováno v:
Experimental & Molecular Medicine
Dopamine D1 receptor (D1DR) and D2 receptor (D2DR) are closely associated with pain modulation, but their exact effects on neuropathic pain and the underlying mechanisms remain to be identified. Our research revealed that intrathecal administration o
Autor:
Hanqing Liu, Manyu Liu, Xiufeng Liu, Chen Shen, Chenhui Ou, Wanli Zhao, Kemeng Liu, Wen-Ling Dai, Ji-Hua Liu
Publikováno v:
Green Chemistry. 23:5944-5955
Tetrahydroprotoberberines (THPBs), mainly sourced from the medicinal plants of genus Stephania and Corydalis, exhibit a variety of pharmacological activities. Plant-sourced THPBs are limited by low yields, and their chemical synthesis faces high cost
Autor:
Hang Xiao, Ji-Hua Liu, Wen-Tao Liu, Liang Hu, Xing Yang, Chen Miao, Ling Song, Liu Han, Wen-Ling Dai, Li Zhang
Publikováno v:
Regional Anesthesia & Pain Medicine. 45:955-963
Background and objectivesGap junctions play a pivotal role in contributing to the formation of astroglial networks and in chronic pain. However, the mechanisms underlying the dysfunction of astroglial gap junctions in chronic pain have not been fully
Publikováno v:
Journal of Advanced Research
Journal of Advanced Research, Vol 28, Iss, Pp 139-148 (2021)
Journal of Advanced Research, Vol 28, Iss, Pp 139-148 (2021)
Graphical abstract
Introduction Spinal N-methyl-D-aspartate receptor (NMDAR) is vital in chronic pain, while NMDAR antagonists have severe side effects. NMDAR has been reported to be controlled by G protein coupled receptors (GPCRs), which might
Introduction Spinal N-methyl-D-aspartate receptor (NMDAR) is vital in chronic pain, while NMDAR antagonists have severe side effects. NMDAR has been reported to be controlled by G protein coupled receptors (GPCRs), which might
Publikováno v:
Regional Anesthesia & Pain Medicine. 45:219-229
Background and objectivesNeuropathic pain is partially refractory to currently available treatments. Although some studies have reported that apoptosis signal-regulating kinase 1 (ASK1) may inhibit chronic pain, the mechanisms underlying this process
Publikováno v:
Engineering in Life Sciences. 19:292-301
Norverapamil, the N-demethylated derivative of verapamil, is a novel promising leading compound for attenuating multidrug resistance with less side effects compared with verapamil. However, the efficient synthetic method for norverapamil is absent. I