Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Wen-jing Lu"'
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Background The histone-lysine N-methyltransferase SMYD1, which is specific to striated muscle, plays a crucial role in regulating early heart development. Its deficiency has been linked to the occurrence of congenital heart disease. Neverthe
Externí odkaz:
https://doaj.org/article/900b3d2aba744013ae638df866c7e395
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-10 (2022)
Abstract Alcoholic cardiomyopathy (ACM) is a myocardial injury caused by long-term heavy drinking. Existing evidence indicates that high levels of oxidative stress are the key to pathological cardiomyopathy caused by long-term exposure to high concen
Externí odkaz:
https://doaj.org/article/62da0faf08d548bc85eb70573b2239a5
Autor:
Yun Chang, Ya-nan Li, Rui Bai, Fujian Wu, Shuhong Ma, Amina Saleem, Siyao Zhang, Youxu Jiang, Tao Dong, Tianwei Guo, Chengwen Hang, Wen-jing Lu, Hongfeng Jiang, Feng Lan
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-13 (2021)
Abstract Background Long-QT syndrome type 2 (LQT2) is a common malignant hereditary arrhythmia. Due to the lack of suitable animal and human models, the pathogenesis of LQT2 caused by human ether-a-go-go-related gene (hERG) deficiency is still unclea
Externí odkaz:
https://doaj.org/article/f2c79cbe72364bf0a1cfbd96a93f4ff5
Autor:
Rui Bai, Yun Chang, Amina Saleem, Fujian Wu, Lei Tian, Siyao Zhang, Ya’nan Li, Shuhong Ma, Tao Dong, Tianwei Guo, Youxu Jiang, Yi You, Wen-Jing Lu, Hong Feng Jiang, Feng Lan
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-17 (2021)
Abstract Introduction Spinal cord injury (SCI) is a neurological, medically incurable disorder. Human pluripotent stem cells (hPSCs) have the potential to generate neural stem/progenitor cells (NS/PCs), which hold promise in the treatment of SCI by t
Externí odkaz:
https://doaj.org/article/22e18ce2d8c946f593a66ae5a6ae78c0
Publikováno v:
Stem Cell Research, Vol 59, Iss , Pp 102652- (2022)
The loss of function of the COL1A2 gene can result in osteogenesis imperfecta (OI) types I, II, III, and IV and Ehlers-Danlos syndrome (cardiac valvular and arthrochalasia type).To further investigate the significance of COL1A2 in osteogenesis imperf
Externí odkaz:
https://doaj.org/article/dc2a2df56ddf457799fb002e6623af36
Publikováno v:
BMC Molecular and Cell Biology, Vol 20, Iss 1, Pp 1-13 (2019)
Abstract Background It was reported that microRNA-21(miR-21) was differentially expressed in the keratinocytes of psoriasis patients, and it may influence the apoptosis and proliferation of cells. The role of lncRNA maternally expressed gene3 (MEG3),
Externí odkaz:
https://doaj.org/article/71193ee98ecb469da4f7a1a4b9e2f042
Publikováno v:
Journal of Integrative Agriculture, Vol 17, Iss 12, Pp 2670-2682 (2018)
Fruit wounding occurred at harvest and transportation requires rapid suberization as a major part of the healing process to prevent infection and desiccation. The focus of this work was to explore the mediation of abscisic acid (ABA) on wound-induced
Externí odkaz:
https://doaj.org/article/28485de131f6409a95c195b5c29b6db9
Publikováno v:
Stem Cell Research, Vol 51, Iss , Pp 102156- (2021)
Holt-Oram syndrome (HOS), which is caused by genetic changes in the TBX5 gene, affects the hands and heart. HOS patients have heart defects, including atrial septal defects (ASD), ventricular septal defects (VSD) and heart conduction disease. Here, w
Externí odkaz:
https://doaj.org/article/6388bf02e892435ca8a467cd573ca4b3
Autor:
Tao Dong, Siyao Zhang, Yun Chang, Rui Bai, Youxu Jiang, Shuhong Ma, Ya'nan Li, Hong Feng Jiang, Wen-Jing Lu
Publikováno v:
Stem Cell Research, Vol 51, Iss , Pp 102196- (2021)
SNTA1 encodes α1-syntrophin, a scaffold protein, which is a component of the dystrophin-associated protein complex. Additionally, α1-syntrophin interacts with SCN5A and nNOS–PMCA4b complex in cardiomyocytes. SNTA1 is a susceptibility locus for ar
Externí odkaz:
https://doaj.org/article/d5de8882c16f41caa5b3b14083ef56a7
Autor:
Ya’nan Li, Yun Chang, Xiaolei Li, Xiaowei Li, Jian Gao, Yafei Zhou, Fujian Wu, Rui Bai, Tao Dong, Shuhong Ma, Siyao Zhang, Wen-Jing Lu, Xiaoqiu Tan, Yongming Wang, Feng Lan
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Ras associated with diabetes (RAD) is a membrane protein that acts as a calcium channel regulator by interacting with cardiac L-type Ca2 + channels (LTCC). RAD defects can disrupt intracellular calcium dynamics and lead to cardiac hypertrophy. Howeve
Externí odkaz:
https://doaj.org/article/b070f5427445468db8d77a714451f3da