Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Wen-Yun Hsueh"'
Autor:
Hao-Wei Lee, Szu-Jung Chen, Kuen-Jer Tsai, Kuei-Sen Hsu, Yi-Fan Chen, Chih-Hua Chang, Hsiao-Han Lin, Wen-Yun Hsueh, Hsing-Pang Hsieh, Yueh-Feng Lee, Huai-Chueh Chiang, Jang-Yang Chang
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-23 (2024)
Abstract Background Cathepsin S (CTSS) is a cysteine protease that played diverse roles in immunity, tumor metastasis, aging and other pathological alterations. At the cellular level, increased CTSS levels have been associated with the secretion of p
Externí odkaz:
https://doaj.org/article/cb18c5ca1d994f6798eb6006543573e6
Autor:
Shu Fu Lin, Li-Wei Teng, Ya-Chi Huang, Shyh-Fong Chen, Guan-Ru Huang, Chih-Lin Chang, Pi-Chen Hsu, Min-Sian Huang, Yu-Sheng Gao, Ya-Wen Chan, Jiann-Jyh Huang, Sheng-Chuan Yang, Bo-Han Jian, Yann-Yu Lu, Yu-Fen Chen, Tzu-Hao Lo, Shih-Hsien Chuang, Wen-Yun Hsueh, Po-Hsun Huang, Hsin-Yi Huang, Lien-Hsiang Chang, Win-Yin Wei, Ying-Chou Chen, Her-Sheng Lin, Shan-Yen Chou, Ta-Tung Yuan, Yu-Ting Chao, Ying-Shuan E. Lee, Yi-Feng Kao, Yu-Hsiang Lin, Jo-Chu Lin, Hung-Huang Liu, Shao-Yun Wang, Chin-Hung Lai, Shin-Yi Huang
Publikováno v:
Journal of Medicinal Chemistry. 64:1435-1453
In this paper, we present a copper(I)-catalyzed nitrile-addition/N-arylation ring-closure cascade for the synthesis of 5,11-dihydro-6H-indolo[3,2-c]quinolin-6-ones from 2-(2-bromophenyl)-N-(2-cyanophenyl)acetamides. Using CuBr and t-BuONa in dimethyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fcb962b8cc2da85f8b630161defbab0
https://doi.org/10.1021/acs.jmedchem.0c00727
https://doi.org/10.1021/acs.jmedchem.0c00727
Autor:
Wen-Yun, Hsueh, Ying-Shuan E, Lee, Min-Sian, Huang, Chin-Hung, Lai, Yu-Sheng, Gao, Jo-Chu, Lin, Yu-Fen, Chen, Chih-Lin, Chang, Shan-Yen, Chou, Shyh-Fong, Chen, Yann-Yu, Lu, Lien-Hsiang, Chang, Shu Fu, Lin, Yu-Hsiang, Lin, Pi-Chen, Hsu, Win-Yin, Wei, Ya-Chi, Huang, Yi-Feng, Kao, Li-Wei, Teng, Hung-Huang, Liu, Ying-Chou, Chen, Ta-Tung, Yuan, Ya-Wen, Chan, Po-Hsun, Huang, Yu-Ting, Chao, Shin-Yi, Huang, Bo-Han, Jian, Hsin-Yi, Huang, Sheng-Chuan, Yang, Tzu-Hao, Lo, Guan-Ru, Huang, Shao-Yun, Wang, Her-Sheng, Lin, Shih-Hsien, Chuang, Jiann-Jyh, Huang
Publikováno v:
Journal of medicinal chemistry. 64(3)
In this paper, we present a copper(I)-catalyzed nitrile-addition/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2f6c10c7f95ae0e1e8f3936e79865440
https://pubmed.ncbi.nlm.nih.gov/33492141
https://pubmed.ncbi.nlm.nih.gov/33492141
Autor:
Cheng-I, Lee, Chu-Bin, Liao, Chih-Shang, Chen, Fen-Ying, Cheng, Yu-Hsuan, Chung, Yu-Chuan, Wang, Sian-Yi, Ciou, Wen-Yun, Hsueh, Tzu-Hao, Lo, Guan-Ru, Huang, Hsin-Yi, Huang, Chia-Shen, Tsai, Yu-Jung, Lu, Shih-Hsien, Chuang, Jiann-Jyh, Huang
Publikováno v:
Bioorganic chemistry. 109
This paper presents the design and synthesis of 4-(3-hydroxyanilino)-6-(1H-1,2,3-triazol-4-yl)quinazolines of scaffold 9 as selective B-Raf/B-Raf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::deff9655caf0e29378379bc113afe49e
https://pubmed.ncbi.nlm.nih.gov/33647741
https://pubmed.ncbi.nlm.nih.gov/33647741
Autor:
Tzu-Hao Lo, Yu-Hsuan Chung, Shih-Hsien Chuang, Cheng-I Lee, Jiann-Jyh Huang, Guan-Ru Huang, Chu-Bin Liao, Chia-Shen Tsai, Wen-Yun Hsueh, Hsin-Yi Huang, Fen-Ying Cheng, Yu-Chuan Wang, Sian-Yi Ciou, Chih-Shang Chen, Yu-Jung Lu
Publikováno v:
Bioorganic Chemistry. 109:104715
This paper presents the design and synthesis of 4-(3-hydroxyanilino)-6-(1H-1,2,3-triazol-4-yl)quinazolines of scaffold 9 as selective B-Raf/B-RafV600E and potent EGFR/VEGFR2 kinase inhibitors. Total 14 compounds of scaffold 9 having different side ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85b175e830fda95836ac9c431c71785c
https://doi.org/10.1016/j.bioorg.2021.104715
https://doi.org/10.1016/j.bioorg.2021.104715