Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Wen-Wen Lin"'
Publikováno v:
Heliyon, Vol 10, Iss 17, Pp e36986- (2024)
The tumor immune microenvironment (TIME) significantly influences cancer progression and treatment. This study sought to uncover novel TIME-related glioma biomarkers to advance antitumor immunotherapies by integrating data from sequencing of bulk RNA
Externí odkaz:
https://doaj.org/article/89440174a05748b3b4bc610999eb7f18
Autor:
Annabel Guichard, Shenzhao Lu, Oguz Kanca, Daniel Bressan, Yan Huang, Mengqi Ma, Sara Sanz Juste, Jonathan C. Andrews, Kristy L. Jay, Marketta Sneider, Ruth Schwartz, Mei-Chu Huang, Danqing Bei, Hongling Pan, Liwen Ma, Wen-Wen Lin, Ankush Auradkar, Pranjali Bhagwat, Soo Park, Kenneth H. Wan, Takashi Ohsako, Toshiyuki Takano-Shimizu, Susan E. Celniker, Michael F. Wangler, Shinya Yamamoto, Hugo J. Bellen, Ethan Bier
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112842- (2023)
Summary: Development of effective therapies against SARS-CoV-2 infections relies on mechanistic knowledge of virus-host interface. Abundant physical interactions between viral and host proteins have been identified, but few have been functionally cha
Externí odkaz:
https://doaj.org/article/984e325c04524d81953603c94fb0a65a
Autor:
Oguz Kanca, Jonathan Zirin, Yanhui Hu, Burak Tepe, Debdeep Dutta, Wen-Wen Lin, Liwen Ma, Ming Ge, Zhongyuan Zuo, Lu-Ping Liu, Robert W Levis, Norbert Perrimon, Hugo J Bellen
Publikováno v:
eLife, Vol 11 (2022)
Previously, we described a large collection of Drosophila strains that each carry an artificial exon containing a T2AGAL4 cassette inserted in an intron of a target gene based on CRISPR-mediated homologous recombination. These alleles permit numerous
Externí odkaz:
https://doaj.org/article/21349c0042e4440c9ed944c980a33c8b
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Gliomas, including brain lower grade glioma (LGG) and glioblastoma multiforme (GBM), are the most common primary brain tumors in the central nervous system. Neuregulin (NRG) family proteins belong to the epidermal growth factor (EGF) family of extrac
Externí odkaz:
https://doaj.org/article/e41b2331f2c9457189832391ca7d7bac
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS), are typically characterized by progressive neuronal loss and neurological dysfunctions in the nervous system, affect
Externí odkaz:
https://doaj.org/article/16e8e41fab9d41a79d2a2a019114d9f8
Autor:
Oguz Kanca, Jonathan Zirin, Jorge Garcia-Marques, Shannon Marie Knight, Donghui Yang-Zhou, Gabriel Amador, Hyunglok Chung, Zhongyuan Zuo, Liwen Ma, Yuchun He, Wen-Wen Lin, Ying Fang, Ming Ge, Shinya Yamamoto, Karen L Schulze, Yanhui Hu, Allan C Spradling, Stephanie E Mohr, Norbert Perrimon, Hugo J Bellen
Publikováno v:
eLife, Vol 8 (2019)
We previously reported a CRISPR-mediated knock-in strategy into introns of Drosophila genes, generating an attP-FRT-SA-T2A-GAL4-polyA-3XP3-EGFP-FRT-attP transgenic library for multiple uses (Lee et al., 2018a). The method relied on double stranded DN
Externí odkaz:
https://doaj.org/article/fbf9b18e540242aa9bc3f668e020beb1
Autor:
Pei-Tseng Lee, Jonathan Zirin, Oguz Kanca, Wen-Wen Lin, Karen L Schulze, David Li-Kroeger, Rong Tao, Colby Devereaux, Yanhui Hu, Verena Chung, Ying Fang, Yuchun He, Hongling Pan, Ming Ge, Zhongyuan Zuo, Benjamin E Housden, Stephanie E Mohr, Shinya Yamamoto, Robert W Levis, Allan C Spradling, Norbert Perrimon, Hugo J Bellen
Publikováno v:
eLife, Vol 7 (2018)
We generated a library of ~1000 Drosophila stocks in which we inserted a construct in the intron of genes allowing expression of GAL4 under control of endogenous promoters while arresting transcription with a polyadenylation signal 3’ of the GAL4.
Externí odkaz:
https://doaj.org/article/df67f9797a394b558a57f36f0b13882f
Publikováno v:
eLife, Vol 7 (2018)
In Drosophila, long-term memory (LTM) requires the cAMP-dependent transcription factor CREBB, expressed in the mushroom bodies (MB) and phosphorylated by PKA. To identify other kinases required for memory formation, we integrated Trojan exons encodin
Externí odkaz:
https://doaj.org/article/2e2cda633bf741b8a786b5d16836fdd2
Autor:
Sonal Nagarkar-Jaiswal, Steven Z DeLuca, Pei-Tseng Lee, Wen-Wen Lin, Hongling Pan, Zhongyuan Zuo, Jiangxing Lv, Allan C Spradling, Hugo J Bellen
Publikováno v:
eLife, Vol 4 (2015)
Previously, we described a large collection of Minos-Mediated Integration Cassettes (MiMICs) that contain two phiC31 recombinase target sites and allow the generation of a new exon that encodes a protein tag when the MiMIC is inserted in a codon intr
Externí odkaz:
https://doaj.org/article/d0b3068e8f7c46cea2d2e55da0a8619c
Autor:
Sonal Nagarkar-Jaiswal, Pei-Tseng Lee, Megan E Campbell, Kuchuan Chen, Stephanie Anguiano-Zarate, Manuel Cantu Gutierrez, Theodore Busby, Wen-Wen Lin, Yuchun He, Karen L Schulze, Benjamin W Booth, Martha Evans-Holm, Koen JT Venken, Robert W Levis, Allan C Spradling, Roger A Hoskins, Hugo J Bellen
Publikováno v:
eLife, Vol 4 (2015)
Here, we document a collection of ∼7434 MiMIC (Minos Mediated Integration Cassette) insertions of which 2854 are inserted in coding introns. They allowed us to create a library of 400 GFP-tagged genes. We show that 72% of internally tagged proteins
Externí odkaz:
https://doaj.org/article/a360211c69524b5c898cb3e9e9faee55