Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Wen-Wei You"'
Autor:
Huo, Xian‐Sen, Tang‐Yang, Ji, Zeng, Wen‐Bin, Jian, Xie‐Er, Ma, Xuan‐Xuan, Yue‐Yang, Peng, Wen‐Wei, You, Zhao, Pei‐Liang
Publikováno v:
Drug Development Research; Aug2023, Vol. 84 Issue 5, p975-987, 13p
Publikováno v:
Bioorganicmedicinal chemistry letters. 75
Based on our previous work, a series of novel 6-arylamino-[1,2,4]triazolo[4,3-a]pyridine derivatives were synthesized, and evaluated for antiproliferative activities. SAR studies revealed that inserting an amino linkage between 6‑aryl group and [1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8651a258471f067a606f396686ce7a
https://pubmed.ncbi.nlm.nih.gov/36089111
https://pubmed.ncbi.nlm.nih.gov/36089111
Publikováno v:
Bioorganicmedicinal chemistry letters. 66
Based on our previous work, a series of novel triazolylthioacetones incorporating pyridine, pyrazine, and 3,4,5-trimethoxybenzyl fragment were synthesized, and evaluated for antiproliferative activities and interactions with tubulin. Some analogues e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a886679eedf62017b0701462ed13af
https://pubmed.ncbi.nlm.nih.gov/35398303
https://pubmed.ncbi.nlm.nih.gov/35398303
Autor:
Xian-Sen Huo, Yu-Feng Ma, Zhi-Ru Chen, Li-Li Yuan, Xiao-Lan Zheng, Xiong-Li Li, Feng-Ting Liang, Wen-Wei You, Peiliang Zhao
A novel series of 2-amino-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxamide derivatives has been achieved successfully via an efficient one-pot three-component Biginelli-like heterocyclization reaction between different benzaldehydes, 1H-1,2,4-triazole-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::858a0da04e772787f7c7965eb1d65928
https://doi.org/10.21203/rs.3.rs-182311/v1
https://doi.org/10.21203/rs.3.rs-182311/v1
Autor:
Pei-Liang Zhao, Ren-Xin He, Yu-Feng Ma, Wen-Wei You, Qiu Li, Xian-Sen Huo, Lin Chen, Xie-Er Jian, Yu Wang
Publikováno v:
Bioorganicmedicinal chemistry letters. 31
Based on our previous work, a novel class of 8-cyclopentyl-7,8-dihydropteridin-6(5H)-one derivatives were synthesized and evaluated as antiproliferative agents. Structure-activity relationship analysis revealed that the greatest activities were achie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0711b6c1c441042515d8fd83034c52b8
https://pubmed.ncbi.nlm.nih.gov/33197548
https://pubmed.ncbi.nlm.nih.gov/33197548
Autor:
Wen-Wei You, Qiu Li, Jin-Jun Rao, Lin Chen, Xie-Er Jian, Zi-Hua Li, Pei-Liang Zhao, Xian-Sen Huo, Zhi-Ru Chen
Publikováno v:
Bioorganic chemistry. 102
A new series of derivatives characterized by the presence of the 3,4,5-trimethoxylbenzamide substituted benzofurans were synthesized and evaluated for antiproliferative activity against four cancer cell lines and one normal human cell line. Among the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c97046cb94c0b2f09b3e8327bd4d37e
https://pubmed.ncbi.nlm.nih.gov/32683180
https://pubmed.ncbi.nlm.nih.gov/32683180
Publikováno v:
Chemical Papers. 72:651-659
As an aspect of our ongoing research on developing novel antiproliferative agents, 31 new triazole–isoindoline hybrids bearing 3,4,5-trimethoxyphenyl moiety were synthesized and evaluated for their antiproliferative activity against four cancer cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::344997af9358f0a69c3001fc825e4692
https://doi.org/10.1007/s11696-017-0311-8
https://doi.org/10.1007/s11696-017-0311-8
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:3954-3958
Based on our previous work, a series of novel 2-amino-7,8-dihydropteridin-6(5H)-one derivatives were designed and synthesized via a ring-closing strategy. Biological evaluation with four human cancer cell lines (BT549, T47D, MDA-MB-468, and MDA-MB-23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c891a962d6fcd678a7d47f24cfbe7922
https://doi.org/10.1016/j.bmcl.2017.07.076
https://doi.org/10.1016/j.bmcl.2017.07.076
Publikováno v:
European Journal of Medicinal Chemistry. 134:110-118
Based on our previous screening hit compound 1, a series of novel indole-pyrimidine hybrids possessing morpholine or thiomorpholine moiety were synthesized via an efficient one-pot multistep synthetic method. The antiproliferative activities of the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcefadc6d42a5db5974c222b7c2cc82a
https://doi.org/10.1016/j.ejmech.2017.04.011
https://doi.org/10.1016/j.ejmech.2017.04.011
Publikováno v:
European Journal of Medicinal Chemistry. 125:1098-1106
Thirty-two novel 3-alkylsulfanyl-1,2,4-triazole derivatives, designed as cis-restricted combretastatin A-4 analogues, were synthesized and evaluated for their antiproliferative activities. The results indicated that analogue 20 showed more potent ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f62cb29110456c6597314821dd8a5268
https://doi.org/10.1016/j.ejmech.2016.10.051
https://doi.org/10.1016/j.ejmech.2016.10.051