γδ T cells mediate robust anti‐HIV functions during antiretroviral therapy regardless of immune checkpoint expression

Autor: Kirsty R Field, Kathleen M Wragg, Stephen J Kent, Wen Shi Lee, Jennifer A Juno

Publikováno v: Clinical & Translational Immunology, Vol 13, Iss 2, Pp n/a-n/a (2024)

Abstract Objectives Although antiretroviral therapy (ART) efficiently suppresses HIV viral load, immune dysregulation and dysfunction persist in people living with HIV (PLWH). γδ T cells are functionally impaired during untreated HIV infection, but

Externí odkaz: https://doaj.org/article/7a36b0859aa54564806241fad485735f

Statement in Support of: 'Virology under the Microscope—a Call for Rational Discourse'

Autor: Peter Speck, Jason Mackenzie, Rowena A. Bull, Barry Slobedman, Heidi Drummer, Johanna Fraser, Lara Herrero, Karla Helbig, Sarah Londrigan, Gregory Moseley, Natalie Prow, Grant Hansman, Robert Edwards, Chantelle Ahlenstiel, Allison Abendroth, David Tscharke, Jody Hobson-Peters, Robson Kriiger-Loterio, Rhys Parry, Glenn Marsh, Emma Harding, David A. Jacques, Matthew J. Gartner, Wen Shi Lee, Julie McAuley, Paola Vaz, Frank Sainsbury, Michelle D. Tate, Jane Sinclair, Allison Imrie, Stephen Rawlinson, Andrew Harman, Jillian M. Carr, Ebony A. Monson, Merilyn Hibma, Timothy J. Mahony, Thomas Tu, Robert J. Center, Lok Bahadur Shrestha, Robyn Hall, Morgyn Warner, Vernon Ward, Danielle E. Anderson, Nicholas S. Eyre, Natalie E. Netzler, Alison J. Peel, Peter Revill, Michael Beard, Alistair R. Legione, Alexandra J. Spencer, Adi Idris, Jade Forwood, Subir Sarker, Damian F. J. Purcell, Nathan Bartlett, Joshua M. Deerain, Bruce J. Brew, Sassan Asgari, Helen Farrell, Alexander Khromykh, Daniel Enosi Tuipulotu, David Anderson, Sevim Mese, Yaman Tayyar, Kathryn Edenborough, Jasim Muhammad Uddin, Abrar Hussain, Connor J. I. Daymond, Jacinta Agius, Karyn N. Johnson, Paniz Shirmast, Mahdi Abedinzadeshahri, Robin MacDiarmid, Caroline L. Ashley, Jay Laws, Lucy L. Furfaro, Thomas D. Burton, Stephen M. R. Johnson, Zahra Telikani, Mary Petrone, Justin A. Roby, Carolyn Samer, Andreas Suhrbier, April Van Der Kamp, Anthony Cunningham, Celeste Donato, Jackie Mahar, Wesley D. Black, Subhash Vasudevan, Roman Lenchine, Kirsten Spann, Daniel J. Rawle, Penny Rudd, Jessica Neil, Richard Kingston, Timothy P. Newsome, Ki Wook Kim, Johnson Mak, Kym Lowry, Nathan Bryant, Joanne Meers, Jason A. Roberts, Nigel McMillan, Larisa I. Labzin, Andrii Slonchak, Leon E. Hugo, Bennett Henzeler, Natalee D. Newton, Cassandra T. David, Patrick C. Reading, Camille Esneau, Tatiana Briody, Najla Nasr, Donna McNeale, Brian McSharry, Omid Fakhri, Bethany A. Horsburgh, Grant Logan, Paul Howley, Paul Young

Publikováno v: mBio, Vol 14, Iss 3 (2023)

Externí odkaz: https://doaj.org/article/d6c7d0d84f3d4d78be8859af3bbe8cc3

Corrigendum: Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2

Autor: Bruce D. Wines, Liriye Kurtovic, Halina M. Trist, Sandra Esparon, Ester Lopez, Klasina Chappin, Li-Jin Chan, Francesca L. Mordant, Wen Shi Lee, Nicholas A. Gherardin, Sheila K. Patel, Gemma E. Hartley, Phillip Pymm, James P. Cooney, James G. Beeson, Dale I. Godfrey, Louise M. Burrell, Menno C. van Zelm, Adam K. Wheatley, Amy W. Chung, Wai-Hong Tham, Kanta Subbarao, Stephen J. Kent, P. Mark Hogarth

Publikováno v: Frontiers in Immunology, Vol 13 (2023)

Externí odkaz: https://doaj.org/article/140fea88883d408989768880a06ffb83

Systems serology detects functionally distinct coronavirus antibody features in children and elderly

Autor: Kevin J. Selva, Carolien E. van de Sandt, Melissa M. Lemke, Christina Y. Lee, Suzanne K. Shoffner, Brendon Y. Chua, Samantha K. Davis, Thi H. O. Nguyen, Louise C. Rowntree, Luca Hensen, Marios Koutsakos, Chinn Yi Wong, Francesca Mordant, David C. Jackson, Katie L. Flanagan, Jane Crowe, Shidan Tosif, Melanie R. Neeland, Philip Sutton, Paul V. Licciardi, Nigel W. Crawford, Allen C. Cheng, Denise L. Doolan, Fatima Amanat, Florian Krammer, Keith Chappell, Naphak Modhiran, Daniel Watterson, Paul Young, Wen Shi Lee, Bruce D. Wines, P. Mark Hogarth, Robyn Esterbauer, Hannah G. Kelly, Hyon-Xhi Tan, Jennifer A. Juno, Adam K. Wheatley, Stephen J. Kent, Kelly B. Arnold, Katherine Kedzierska, Amy W. Chung

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Antibody responses to SARS-CoV-2 are critical in the immune response to infection, but the potential cross-reactivity to other human corona viruses is poorly appreciated. Here the authors apply a systems based approach to characterise the antibody re

Externí odkaz: https://doaj.org/article/b3735969bc2442d3bede1a835ba02866

Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19

Autor: Adam K. Wheatley, Jennifer A. Juno, Jing J. Wang, Kevin J. Selva, Arnold Reynaldi, Hyon-Xhi Tan, Wen Shi Lee, Kathleen M. Wragg, Hannah G. Kelly, Robyn Esterbauer, Samantha K. Davis, Helen E. Kent, Francesca L. Mordant, Timothy E. Schlub, David L. Gordon, David S. Khoury, Kanta Subbarao, Deborah Cromer, Tom P. Gordon, Amy W. Chung, Miles P. Davenport, Stephen J. Kent

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)

Longitudinal analyses are needed to show how the immune response to Sars-Cov-2 infection changes over time. Here, the authors use multiple strategies to profile the change in immune cell responses from patients with convalescent COVID-19 over the cou

Externí odkaz: https://doaj.org/article/e4e8f1c116754d5288a334fd4274b5ac