Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Wen-Shan Zhao"'
Autor:
Xiu-Man Zhou, Wan-Qiong Li, Ya-Hong Wu, Lu Han, Xin-Guang Cao, Xuan-Ming Yang, Hong-Fei Wang, Wen-Shan Zhao, Wen-Jie Zhai, Yuan-Ming Qi, Yan-Feng Gao
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
TIGIT, an immune checkpoint molecule widely expressed on NK cells, activated T cells and Tregs, has been involved in delivering inhibitory signals through the interaction with PVR. The blockade of TIGIT/PVR interaction is a promising approach in canc
Externí odkaz:
https://doaj.org/article/1386dcba6fc24a179601f02e399bdfea
Autor:
Yang Xu, Xiao-Ning Wu, Yi-Wen Shi, Wei Wei, Ai-Ting Yang, Ya-Meng Sun, Wen-Shan Zhao, Hong You
Publikováno v:
Chinese Medical Journal, Vol 128, Iss 14, Pp 1867-1872 (2015)
Background: Cirrhosis is a common complication of chronic hepatitis B. It remains unclear if viral and biochemical parameters at baseline affect virological response to entecavir and therefore warrant investigation. In the present study, we aimed to
Externí odkaz:
https://doaj.org/article/467ef3b160584af99bc97494f0765a10
TGF-β1 Induces the Dual Regulation of Hepatic Progenitor Cells with Both Anti- and Proliver Fibrosis
Autor:
Ai-Ting Yang, Dou-Dou Hu, Ping Wang, Min Cong, Tian-Hui Liu, Dong Zhang, Ya-Meng Sun, Wen-Shan Zhao, Ji-Dong Jia, Hong You
Publikováno v:
Stem Cells International, Vol 2016 (2016)
Transforming growth factor-beta 1 (TGF-β1) plays a central role in hepatic progenitor cells- (HPCs-) mediated liver repair and fibrosis. However, different effects of TGF-β1 on progenitor cells have not been described. In this study, both in vitro
Externí odkaz:
https://doaj.org/article/57f473d63a5b44818e8aab3fe9aad63e
Autor:
Li-Dong Huang, Ying-Zhe Fan, Yun Tian, Yang Yang, Yan Liu, Jin Wang, Wen-Shan Zhao, Wen-Chao Zhou, Xiao-Yang Cheng, Peng Cao, Xiang-Yang Lu, Ye Yu
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97528 (2014)
P2X receptors are ATP-gated ion channels involved in many physiological functions, and determination of ATP-recognition (AR) of P2X receptors will promote the development of new therapeutic agents for pain, inflammation, bladder dysfunction and osteo
Externí odkaz:
https://doaj.org/article/01f7b189c8bc4425a8ae2780a94456e0
Autor:
Ye Yu, Xiaoyang Cheng, Wen Shan Zhao, Bin Li, You Min Hu, Xue Fei Ma, Yang Yang, Wen Wen Cui, Li Dong Huang, Yun Tian, Jin Wang, Yan Liu, Lingyong Li, Xiang Yang Lu, Liang Fei Sun
Publikováno v:
Journal of Biological Chemistry. 292:7619-7635
P2X receptors are ATP-gated trimeric channels with important roles in diverse pathophysiological functions. A detailed understanding of the mechanism underlying the gating process of these receptors is thus fundamentally important and may open new th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d1485b8764de90799ce12ee22c3f67
https://doi.org/10.1074/jbc.m116.771121
https://doi.org/10.1074/jbc.m116.771121
Autor:
Rui Wang, Peng Cao, Wang Sheng Sun, Yichen Huang, Motoyuki Hattori, Michael X. Zhu, Wen Shan Zhao, Jin Wang, Wen Wen Cui, Ye Yu, Yao Wang, Xiaoyang Cheng, Yang Yang, Yan Liu
Allosteric modulation provides exciting opportunities for drug discovery of enzymes, ion channels, and G protein-coupled receptors. As cation channels gated by extracellular ATP, P2X receptors have attracted wide attention as new drug targets. Althou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::465f531ac141ae2c4aed42e69e595cdc
https://europepmc.org/articles/PMC5948998/
https://europepmc.org/articles/PMC5948998/
Autor:
Xiaoyang Cheng, Li Dong Huang, Wen Shan Zhao, Lingyong Li, Ying Zhe Fan, Peng Cao, Liang Fei Sun, You Min Hu, Rui Wang, Yang Yang, Yan Liu, Ye Yu, Meng Yang Sun, Yun Tian
Publikováno v:
The Journal of biological chemistry. 291(15)
Significant progress has been made in understanding the roles of crucial residues/motifs in the channel function of P2X receptors during the pre-structure era. The recent structural determination of P2X receptors allows us to reevaluate the role of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92594a356358daadfdd7d5175a571fd6
https://pubmed.ncbi.nlm.nih.gov/26865631
https://pubmed.ncbi.nlm.nih.gov/26865631
Autor:
Rui Wang, Yan Liu, Wen-Shan Zhao, Ying-Zhe Fan, Yang Yang, Xiaoyang Cheng, Hong-Zhuan Chen, Xiao-Juan Ma, Jin Wang, Ye Yu, Li-Dong Huang
Publikováno v:
Nature communications. 5
Channel gating in response to extracellular ATP is a fundamental process for the physiological functions of P2X receptors. Here we identify coordinated allosteric changes in the left flipper (LF) and dorsal fin (DF) domains that couple ATP-binding to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e348ced4045ee742b1c0a799f9b89ecd
https://pubmed.ncbi.nlm.nih.gov/24943126
https://pubmed.ncbi.nlm.nih.gov/24943126
Autor:
Jin Wang, Yao Wang, Wen-Wen Cui, Yichen Huang, Yang Yang, Yan Liu, Wen-Shan Zhao, Xiao-Yang Cheng, Wang-Sheng Sun, Peng Cao, Zhu, Michael X., Rui Wang, Motoyuki Hattori, Ye Yu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 5/8/2018, Vol. 115 Issue 19, p4939-4944, 6p
Autor:
Yan Liu, Li-Dong Huang, Xiang Yang Lu, Yang Yang, Wen-Chao Zhou, Yun Tian, Ying-Zhe Fan, Jin Wang, Xiaoyang Cheng, Wen-Shan Zhao, Ye Yu, Peng Cao
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97528 (2014)
PLoS ONE
PLoS ONE
P2X receptors are ATP-gated ion channels involved in many physiological functions, and determination of ATP-recognition (AR) of P2X receptors will promote the development of new therapeutic agents for pain, inflammation, bladder dysfunction and osteo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::959190b25718e5f18d61f3afe7ba4eb6
https://doi.org/10.1371/journal.pone.0097528
https://doi.org/10.1371/journal.pone.0097528