Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Wen-Lang Lin"'
Publikováno v:
Free Neuropathology, Vol 1 (2020)
Background: The majority of cases of frontotemporal lobar degeneration (FTLD) are characterized by focal cortical atrophy with an underlying tau or TDP-43 proteinopathy. A subset of FTLD cases, however, lack tau and TDP-43 immunoreactivity, but have
Externí odkaz:
https://doaj.org/article/b1053bf272a349769d3e5604473f566c
Autor:
Kasey L Jackson, Wen-Lang Lin, Sumitra Miriyala, Robert D Dayton, Manikandan Panchatcharam, Kevin J McCarthy, Monica Castanedes-Casey, Dennis W Dickson, Ronald L Klein
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169291 (2017)
One of the proteins most frequently found in neuropathological lesions is the ubiquitin binding protein p62 (sequestosome 1). Post-mortem analysis of p62 is a defining diagnostic marker in several neurodegenerative diseases including amyotrophic late
Externí odkaz:
https://doaj.org/article/3dee2022fb8c45f6b60958ecc55492be
Autor:
Sara Busatto, George Vilanilam, Taylor Ticer, Wen-Lang Lin, Dennis W. Dickson, Shane Shapiro, Paolo Bergese, Joy Wolfram
Publikováno v:
Cells, Vol 7, Iss 12, p 273 (2018)
Concentration of extracellular vesicles (EVs) from biological fluids in a scalable and reproducible manner represents a major challenge. This study reports the use of tangential flow filtration (TFF) for the highly efficient isolation of EVs from lar
Externí odkaz:
https://doaj.org/article/e911a9a9497e4212b03e9afb438af0cb
Publikováno v:
Neurobiology of Disease, Vol 20, Iss 1, Pp 64-73 (2005)
Using a viral vector for mutant (P301L) tau, we studied the effects of gene transfer to the rat substantia nigra in terms of structural and functional properties of dopaminergic neurons. The mutant tau vector caused progressive loss of pars compacta
Externí odkaz:
https://doaj.org/article/a7585fbd8e21480fb8d6503c09d807c7
Autor:
Cindy Zehr, Jada Lewis, Eileen McGowan, Julia Crook, Wen-Lang Lin, Kate Godwin, Joshua Knight, Dennis W Dickson, Mike Hutton
Publikováno v:
Neurobiology of Disease, Vol 15, Iss 3, Pp 553-562 (2004)
Transgenic mice overexpressing human tau with the P301L mutation develop neurofibrillary tangles, extensive gliosis, adult-onset motor abnormalities, and neuronal loss in affected brain regions. We investigated the mechanism of neuronal cell death in
Externí odkaz:
https://doaj.org/article/4ef6b8dafab54eb48ed6eb9b88fb1212
Autor:
Jui-Hung Chang, Ju-Pin Pan, Der-Yan Tai, Ai-Chun Huang, Pi-Hung Li, Hui-Ling Ho, Hui-Ling Hsieh, Shiu-Ching Chou, Wen-Lang Lin, Eric Lo, Ching-Yu Chang, Jerming Tseng, Ming-Tsan Su, Guey-Jen Lee-Chen
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 10, Pp 1850-1858 (2003)
DNA screening for LDL receptor mutations was performed in 170 unrelated hyperlipidemic Chinese patients and two clinically diagnosed familial hypercholesterolemia patients. Two deletions (Del e3-5 and Del e6-8), eight point mutations (W-18X, D69N, R9
Externí odkaz:
https://doaj.org/article/5d0f0d9ce96f433fab65b79efbafd683
Autor:
Yari Carlomagno, Yongjie Zhang, Mary Davis, Wen-Lang Lin, Casey Cook, Judy Dunmore, William Tay, Kyle Menkosky, Xiangkun Cao, Leonard Petrucelli, Michael Deture
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90452 (2014)
Trans-activation Response DNA-binding Protein-43 (TDP-43) lesions are observed in Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Lobar Degeneration with ubiquitin inclusions (FTLD-TDP) and 25-50% of Alzheimer's Disease (AD) cases. These abnormal
Externí odkaz:
https://doaj.org/article/3510b5bd547a410d9f499cd3ea26c3fb
Publikováno v:
Neurology; 6/11/2024, Vol. 102 Issue 11, p1-5, 5p
Autor:
Wen-Lang Lin, 林文郎
93
Netrin and Hh protein families have critical functions in regulating early developmental processes of embryo. Both families have been known to participate in establishing central and peripheral nervous system. In the past years, many scientis
Netrin and Hh protein families have critical functions in regulating early developmental processes of embryo. Both families have been known to participate in establishing central and peripheral nervous system. In the past years, many scientis
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/95241576438564058497
Autor:
Wen-Lang Lin, 林文郎
92
In this paper, a cerebellar model articulation controller (CMAC) neural network application to fault diagnosis is proposed. This novel fault diagnosis system contains an input layer, quantization layer, binary coding layer, and fired up memor
In this paper, a cerebellar model articulation controller (CMAC) neural network application to fault diagnosis is proposed. This novel fault diagnosis system contains an input layer, quantization layer, binary coding layer, and fired up memor
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/79105970291524266643