Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Wen-Jun Xin"'
Autor:
Dai Li, Jing-Wen Mai, Jie Deng, Li Chen, Hai-Ting Fan, Wei-Lin Zhang, Wen-Jun Xin, Xia Feng, Ting Xu, De-Xing Luo
Publikováno v:
Neurobiology of Disease, Vol 202, Iss , Pp 106699- (2024)
Top-down projections transmit a series of signals encoding pain sensation to the ventrolateral periaqueductal gray (vlPAG), where they converge with various incoming projections to regulate pain. Clarifying the upstream regulatory hierarchy of vlPAG
Externí odkaz:
https://doaj.org/article/e21a68742a47412a853355aa3595d9a4
Autor:
Jie Deng, Li Chen, Cui‐Cui Liu, Meng Liu, Guo‐Qing Guo, Jia‐You Wei, Jian‐Bo Zhang, Hai‐Ting Fan, Zi‐Kun Zheng, Pu Yan, Xiang‐Zhong Zhang, Feng Zhou, Sui‐Xiang Huang, Ji‐Feng Zhang, Ting Xu, Jing‐Dun Xie, Wen‐Jun Xin
Publikováno v:
Advanced Science, Vol 11, Iss 34, Pp n/a-n/a (2024)
Abstract Clinically, chronic pain and depression often coexist in multiple diseases and reciprocally reinforce each other, which greatly escalates the difficulty of treatment. The neural circuit mechanism underlying the chronic pain/depression comorb
Externí odkaz:
https://doaj.org/article/02d7e81f8a0b43f588c5c2e513c37f84
Autor:
Jun-Zhi Zhou, Jie Deng, De-Xing Luo, Jing-Wen Mai, Jia-Yan Wu, Yu-Juan Duan, Bo Dong, Wen-Jun Xin, Ting Xu, Jia-You Wei
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
IntroductionIt is well known that there are significant differences in the prevalence of chronic pain between males and females. Human and animal imaging studies have shown that chronic pain profoundly alters the structure and function of brain regio
Externí odkaz:
https://doaj.org/article/8c07854cfddd41c29a85928aaf853daa
Autor:
Ting Xu, Jing Wang, Yan Wu, Jia‐Yan Wu, Wei‐Cheng Lu, Meng Liu, Su‐Bo Zhang, Dan Xie, Wen‐Jun Xin, Jing‐Dun Xie
Publikováno v:
Advanced Science, Vol 10, Iss 35, Pp n/a-n/a (2023)
Abstract N4‐Acetylcytidine (ac4C), a highly conserved post‐transcriptional machinery with extensive existence for RNA modification, plays versatile roles in various cellular processes and functions. However, the molecular mechanism by which ac4C
Externí odkaz:
https://doaj.org/article/ae10c1d64ec6457c888fd982772f9a6f
Autor:
Yu-Ting Zhao, Jie Deng, He-Ming Liu, Jia-You Wei, Hai-Ting Fan, Meng Liu, Ting Xu, Ting-Feng Chen, Jing-Yi He, Wei-Ming Sun, Tao-Yu Jia, Xue-Qin Zhang, Wen-Jun Xin
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-16 (2022)
Abstract Background The adaption of brain region is fundamental to the development and maintenance of nervous system disorders. The prelimbic cortex (PrL) participates in the affective components of the pain sensation. However, whether and how the ad
Externí odkaz:
https://doaj.org/article/34d46d57104642c09ed5d2d79cca73ba
Autor:
Meng Liu, Su-Bo Zhang, Yu-Xuan Luo, Yan-Ling Yang, Xiang-Zhong Zhang, Bo Li, Yan Meng, Yuan-Jie Chen, Rui-Xian Guo, Yuan-Chang Xiong, Wen-Jun Xin, Dai Li
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-12 (2020)
Abstract Background The major dose-limiting toxicity of paclitaxel, one of the most commonly used drugs to treat solid tumor, is painful neuropathy. However, the molecular mechanisms underlying paclitaxel-induced painful neuropathy are largely unclar
Externí odkaz:
https://doaj.org/article/f2b86f125c4347bb9a3587344951ac27
Autor:
Su-Bo Zhang, Su-Yan Lin, Meng Liu, Cui-Cui Liu, Huan-Huan Ding, Yang Sun, Chao Ma, Rui-Xian Guo, You-You Lv, Shao-Ling Wu, Ting Xu, Wen-Jun Xin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Circular RNAs are non-coding RNAs that are enriched in the CNS, but their role in chronic pain is not known. Here the authors show that CircAnks1a in dorsal horn neurons contributes to pain-like hypersensitivity in a rodent model of neuropathic pain,
Externí odkaz:
https://doaj.org/article/b3ac0bb11f9b43cf9fde25c82e822ad5
Autor:
Huan-Huan Ding, Su-Bo Zhang, You-You Lv, Chao Ma, Meng Liu, Kui-Bo Zhang, Xiang-Cai Ruan, Jia-You Wei, Wen-Jun Xin, Shao-Ling Wu
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-10 (2019)
Abstract Background Studies showed that upregulation of Nav1.6 increased the neuronal excitability and participated in neuropathic pain in the dorsal root ganglion (DRG). However, the molecular mechanisms underlying Nav1.6 upregulation were not repor
Externí odkaz:
https://doaj.org/article/368a059de8bb4451aeca7504f98e3d9e
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-10 (2018)
Abstract Background Bortezomib is a frequently used chemotherapeutic drug for the treatment of multiple myeloma and other nonsolid malignancies. Accumulating evidence has demonstrated that bortezomib-induced persistent pain serves as the most frequen
Externí odkaz:
https://doaj.org/article/d378c21953784f8c8ba0eda439cbf515
Publikováno v:
Neurobiology of Disease, Vol 130, Iss , Pp 104456- (2019)
Injury associated pain involves subjective perception and emotional experience. The anterior cingulate cortex (ACC) is a key area involved in the affective component of pain processing. However, the neuroimmune mechanisms underlying enhanced ACC exci
Externí odkaz:
https://doaj.org/article/cc66ff6ca4ee47bbb5de1bcc584e0b18