Zobrazeno 1 - 10
of 414
pro vyhledávání: '"Wen-Hwa Lee"'
Oncogenic KRAS, Mucin 4, and Activin A‐Mediated Fibroblast Activation Cooperate for PanIN Initiation
Autor:
Chun‐Mei Hu, Chien‐Chang Huang, Min‐Fen Hsu, Hung‐Jen Chien, Pei‐Jung Wu, Yi‐Ing Chen, Yung‐Ming Jeng, Shiue‐Cheng Tang, Mei‐Hsin Chung, Chia‐Ning Shen, Ming‐Chu Chang, Yu‐Ting Chang, Yu‐Wen Tien, Wen‐Hwa Lee
Publikováno v:
Advanced Science, Vol 10, Iss 36, Pp n/a-n/a (2023)
Abstract Over 90% of patients with pancreatic ductal adenocarcinoma (PDAC) have oncogenic KRAS mutations. Nevertheless, mutated KRAS alone is insufficient to initiate pancreatic intraepithelial neoplasia (PanIN), the precursor of PDAC. The identities
Externí odkaz:
https://doaj.org/article/4a0e87c67012457eb7ccce5aa913ffd6
Publikováno v:
Cell Death and Disease, Vol 13, Iss 9, Pp 1-10 (2022)
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and deadliest cancer worldwide. The primary reasons for this are the lack of early detection methods and targeted therapy. Emerging evidence highlights the metabolic addic
Externí odkaz:
https://doaj.org/article/564f255bac1a4791b7d9b969ef265d4d
Autor:
Yi-Ing Chen, Chin-Chun Chang, Min-Fen Hsu, Yung-Ming Jeng, Yu-Wen Tien, Ming-Chu Chang, Yu-Ting Chang, Chun-Mei Hu, Wen-Hwa Lee
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Direct contact between tumour cells and fibroblasts influences tumour cell behaviour. Here the authors show that pancreatic cancer cells and fibroblasts directly interact via homophilic ATP1A1 binding, which induces fibroblasts to secrete activin A t
Externí odkaz:
https://doaj.org/article/0ef09420616e4351be36b283dc768cbd
Autor:
Jye‐Lin Hsu, Jen‐Wei Chou, Tzu‐Fan Chen, Jeh‐Ting Hsu, Fang‐Yi Su, Joung‐Liang Lan, Po‐Chang Wu, Chun‐Mei Hu, Eva Y‐HP Lee, Wen‐Hwa Lee
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract Human caspase‐4 and its mouse homolog caspase‐11 are receptors for cytoplasmic lipopolysaccharide. Activation of the caspase‐4/11‐dependent NLRP3 inflammasome is required for innate defense and endotoxic shock, but how caspase‐4/11
Externí odkaz:
https://doaj.org/article/6469a715b25a45098db3375d47ceb2e7
Autor:
Yung-Lin Hsieh, Fang-Yi Su, Li-Kai Tsai, Chien-Chang Huang, Yi-Ling Ko, Li-Wen Su, Kai-Yun Chen, Hsiu-Ming Shih, Chun-Mei Hu, Wen-Hwa Lee
Publikováno v:
Cell Reports, Vol 29, Iss 8, Pp 2134-2143.e7 (2019)
Summary: Amyotrophic lateral sclerosis (ALS), the most common motor neuron disease, usually occurs in middle-aged people. However, the molecular basis of age-related cumulative stress in ALS pathogenesis remains elusive. Here, we found that mice defi
Externí odkaz:
https://doaj.org/article/22eb0f2bbc8d4995b37c7c23f0680a3f
Autor:
Chun-Kai Huang, Po-Hao Chang, Wen-Hung Kuo, Chi-Long Chen, Yung-Ming Jeng, King-Jen Chang, Jin-Yuh Shew, Chun-Mei Hu, Wen-Hwa Lee
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Invasion of the adipose tissue correlates with poor prognosis in breast cancer. Here, the authors show that mammary gland adipocytes promote malignancy via β-hydroxybutyrate, which acts on cancer cells through the monocarboxylate transporter MCT2 re
Externí odkaz:
https://doaj.org/article/722e51da423e4a8a8df28fb9227a5890
Induction of IL-25 secretion from tumour-associated fibroblasts suppresses mammary tumour metastasis
Autor:
Shu-Yi Yin, Feng-Yin Jian, Yung-Hsiang Chen, Shih-Chang Chien, Mao-Chih Hsieh, Pei-Wen Hsiao, Wen-Hwa Lee, Yueh-Hsiung Kuo, Ning-Sun Yang
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Interleukin-25 has been reported to have anticancer activity with very little effect on non-malignant cells. Here, the authors show that a synthetic phytochemical can be used to induce the secretion of Interleukin-25 from tumour associated fibroblast
Externí odkaz:
https://doaj.org/article/b854c0abfbef4aea9b063916b10162c6
Autor:
Jia-Yang Chen, Wen-Sy Tsai, Hung-Jen Shao, Jen-Chia Wu, Jr-Ming Lai, Si-Hong Lu, Tsung-Fu Hung, Chih-Tsung Yang, Liang-Chun Wu, Jinn-Shiun Chen, Wen-Hwa Lee, Ying-Chih Chang
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0149633 (2016)
Here we presented a simple and effective membrane mimetic microfluidic device with antibody conjugated supported lipid bilayer (SLB) "smart coating" to capture viable circulating tumor cells (CTCs) and circulating tumor microemboli (CTM) directly fro
Externí odkaz:
https://doaj.org/article/0ec936314ddb424b948c7c307dfb9f27
Publikováno v:
Journal of the Formosan Medical Association, Vol 107, Iss 10, Pp 751-766 (2008)
Studies of breast cancer stem cells are in their infancy and many fundamental questions have yet to be fully addressed. The molecular distinction between normal and cancerous breast stem cells is not clear. While there have been recent breakthroughs
Externí odkaz:
https://doaj.org/article/47eeaec0ac214f0facfc8c3e9fd3ad8f
Autor:
Li-Fang Lin, Chien-Feng Li, Wei-Jan Wang, Wen-Ming Yang, Dennis Ding-Hwa Wang, Wen-Chang Chang, Wen-Hwa Lee, Ju-Ming Wang
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e73033 (2013)
ZBRK1, a zinc finger protein that interacts with breast cancer 1 (BRCA1) and KRAB-ZFP-associated protein 1 (KAP1), has been suggested to serve as a tumor suppressor via repression of tumor metastasis/invasion. To date, the detailed molecular mechanis
Externí odkaz:
https://doaj.org/article/5f6d678dca1b4d24a505e83ccf493d25