Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Wen-Hai Shao"'
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-12 (2022)
Abstract Background Lupus nephritis (LN) is the most common and serious complication of systemic lupus erythematosus (SLE). LN pathogenesis is not fully understood. Axl receptor tyrosine kinase is upregulated and contributes to the pathogenic progres
Externí odkaz:
https://doaj.org/article/2dab5154ba9c4783a3a9f0daef9c3a33
Publikováno v:
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-10 (2020)
Abstract Background The mechanisms involved in the pathogenesis of autoimmune disorders, including systemic lupus erythematosus (SLE), have not been fully elucidated. Some of these mechanisms involve epigenetic regulation of gene expression. The hist
Externí odkaz:
https://doaj.org/article/c110bc951a9641cb9eab816f75bedbcf
Publikováno v:
Cells, Vol 11, Iss 12, p 1869 (2022)
Axl receptor tyrosine kinase expression in the kidney contributes to a variety of inflammatory renal disease by promoting glomerular proliferation. Axl expression in the kidney is negligible in healthy individuals but upregulated under inflammatory c
Externí odkaz:
https://doaj.org/article/a2c2e373474542e1919f72a7a204f294
Autor:
David E. Adams, Wen-Hai Shao
Publikováno v:
Cells, Vol 11, Iss 3, p 506 (2022)
Systemic lupus erythematosus (SLE) is an autoimmune disorder that is characterized by autoantibody production and dysregulated immune cell activation. Although the exact etiology of SLE remains unknown, genetic, hormonal, and complex environmental fa
Externí odkaz:
https://doaj.org/article/ef926ae770bd4e01ad3d23cc53dea287
Publikováno v:
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-10 (2020)
Arthritis Research & Therapy
Arthritis Research & Therapy
Background The mechanisms involved in the pathogenesis of autoimmune disorders, including systemic lupus erythematosus (SLE), have not been fully elucidated. Some of these mechanisms involve epigenetic regulation of gene expression. The histone methy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46dfad482d75f03f708f323d7ff5adad
http://link.springer.com/article/10.1186/s13075-020-02225-9
http://link.springer.com/article/10.1186/s13075-020-02225-9
Publikováno v:
J Leukoc Biol
Glomerulonephritis (GN), an important pathologic feature of many renal diseases, is frequently characterized by mesangial cell proliferation. We and others have previously shown that the TAM family receptor tyrosine kinases Axl, Mer, and Tyro-3 contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757842bb4efc5a115c2ba0162aa6109b
https://pubmed.ncbi.nlm.nih.gov/34218441
https://pubmed.ncbi.nlm.nih.gov/34218441
Autor:
Wen-Hai Shao, Philip L. Cohen
Publikováno v:
Disease Markers
Disease Markers, Vol 2019 (2019)
Disease Markers, Vol 2019 (2019)
Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease associated with impaired immune system regulation. The exact mechanisms of SLE development remain to be elucidated. TAM receptor tyrosine kinases (RTKs) are important for apoptotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e011153ef286dea3afaa7dbb86d469d2
https://doi.org/10.1155/2019/7838195
https://doi.org/10.1155/2019/7838195
Publikováno v:
Journal of Autoimmunity. 93:37-44
Glomerulonephritis (GN) is a typical lesion in autoantibody and immune complex disorders, including SLE. Because the Gas6/Axl pathway has been implicated in the pathogenesis of many types of GN, targeting this pathway might ameliorate GN. Consequentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98945179b7803ea9240ee5a0fa698997
https://doi.org/10.1016/j.jaut.2018.06.001
https://doi.org/10.1016/j.jaut.2018.06.001
Publikováno v:
Journal of Leukocyte Biology. 103:709-717
Endotoxin induces a variety of proinflammatory mediators and plays a crucial role in kidney inflammation. The receptor tyrosine kinase, Mer, diminishes renal inflammation by attenuating inflammatory responses. We previously reported that Mer is predo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2bebf2edbbeecacb680b1a63876548
https://doi.org/10.1002/jlb.3a0917-368r
https://doi.org/10.1002/jlb.3a0917-368r
Autor:
Yuxuan Zhen, Wen-Hai Shao
Publikováno v:
J Vis Exp
Cell apoptosis is a natural process and plays a critical role in the embryonic development, homeostatic regulation, immune tolerance induction, and resolution of inflammation. Accumulation of apoptotic debris in the body may trigger chronic inflammat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b15cf359569d738383f8e8df57a66fb
https://pubmed.ncbi.nlm.nih.gov/31180346
https://pubmed.ncbi.nlm.nih.gov/31180346