Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Wen-Bing Ai"'
The miR-23b/27b/24-1 Cluster Inhibits Hepatic Fibrosis by Inactivating Hepatic Stellate CellsSummary
Autor:
Lin-Yan Wan, Hu Peng, Yi-Ran Ni, Xue-Ping Jiang, Jiao-Jiao Wang, Yan-Qiong Zhang, Lan Ma, Rui Li, Lin Han, Yong Tan, Jun-Ming Li, Wen-Li Cai, Wen-Fang Yuan, Jia-Jie Liang, Lu Huang, Xu Wu, Quan Zhou, Qi-Ni Cheng, Xue Yang, Meng-Yuan Liu, Wen-Bing Ai, Chang-Bai Liu, Hongbing Zhang, Jiang-Feng Wu
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 5, Pp 1393-1412 (2022)
Background & Aims: Hepatic fibrosis is characterized by hepatic stellate cell (HSC) activation and transdifferentiation-mediated extracellular matrix (ECM) deposition, which both contribute to cirrhosis. However, no antifibrotic regimen is available
Externí odkaz:
https://doaj.org/article/bea4a956fea14e4aa23d9a85599c23b2
Publikováno v:
Annals of Hepatology, Vol 27, Iss 5, Pp 100720- (2022)
Golgi protein 73 (also known as GP73 or GOLPH2) is a transmembrane glycoprotein present in the Golgi apparatus. In diseased states, GP73 is expressed by hepatocytes rather than by bile duct epithelial cells. Many studies have reported that serum GP73
Externí odkaz:
https://doaj.org/article/639ced4e3f5e41d78c3a56b759decb8d
Publikováno v:
Cell & Bioscience, Vol 8, Iss 1, Pp 1-8 (2018)
Abstract Increasing evidence indicates that long non-coding RNAs (lncRNAs) regulate gene or protein expression; however, their function in the progression of hepatic fibrosis remains unclear. Hepatic fibrosis is a continuous wound-healing process cau
Externí odkaz:
https://doaj.org/article/864547a491ea4cf8b16dc6786623376a
Publikováno v:
Cell & Bioscience, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Increasing evidence indicates that embryonic stem cell specific microRNAs (miRNAs) play an essential role in the early development of embryo. Among them, the miR-290-295 cluster is the most highly expressed in the mouse embryonic stem cells
Externí odkaz:
https://doaj.org/article/9e80183b7c424835b700cfa4b6eb9392
Publikováno v:
Cell & Bioscience, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract When hepatocytes are damaged severely, a variety of signaling pathways will be triggered by inflammatory factors and cytokines involving in the process of hepatic fibrosis. The microRNA (miRNA) family consists of several miRNAs which have th
Externí odkaz:
https://doaj.org/article/8fd2925c37c9492485349627aa44c24f
Autor:
Wen-Fang Yuan, Lin-Yan Wan, Yan-Qiong Zhang, Wen-Bing Ai, Jiang-Feng Wu, Yuan-Mei Zhong, Wen-Li Cai, Hu Peng
Publikováno v:
Cell Biochemistry and Function
G-quadruplexes form folded structures because of tandem repeats of guanine sequences in DNA or RNA. They adopt a variety of conformations, depending on many factors, including the type of loops and cations, the nucleotide strand number, and the main
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4c243e413e74748c655f9ef0efb320
http://europepmc.org/articles/PMC7383576
http://europepmc.org/articles/PMC7383576
Autor:
Lin-Yan Wan, Hu Peng, Yi-Ran Ni, Xue-Ping Jiang, Jiao-Jiao Wang, Yan-Qiong Zhang, Lan Ma, Rui Li, Lin Han, Yong Tan, Jun-Ming Li, Wen-Li Cai, Wen-Fang Yuan, Jia-Jie Liang, Lu Huang, Xu Wu, Quan Zhou, Qi-Ni Cheng, Xue Yang, Meng-Yuan Liu, Wen-Bing Ai, Chang-Bai Liu, Hongbing Zhang, Jiang-Feng Wu
Publikováno v:
Cellular and molecular gastroenterology and hepatology. 13(5)
Hepatic fibrosis is characterized by hepatic stellate cell (HSC) activation and transdifferentiation-mediated extracellular matrix (ECM) deposition, which both contribute to cirrhosis. However, no antifibrotic regimen is available in the clinic. micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78a1311c60aa2ef14019eb1c0eeb801a
https://pubmed.ncbi.nlm.nih.gov/35093591
https://pubmed.ncbi.nlm.nih.gov/35093591
Autor:
Jiao-Jiao Wang, Huai-Jie Yang, Jia-Jie Liang, Xiao-Hui Liu, Yi-Ran Ni, Wen-Bing Ai, Jiang-Feng Wu, Yan-Qiong Zhang, Lan Ma, Hu Peng
Publikováno v:
Journal of Biological Research
E proteins are transcriptional regulators that regulate many developmental processes in animals and lymphocytosis and leukemia in Homo sapiens. In particular, E2A, a member of the E protein family, plays a major role in the transcriptional regulatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454ebe1149f991e9dd58e9eab5e642b1
http://europepmc.org/articles/PMC8283981
http://europepmc.org/articles/PMC8283981
Autor:
Yao-Wei Ai, Jiao-Jiao Wang, Jiang-Feng Wu, Wen-Bing Ai, Yan-Qiong Zhang, Lin-Yan Wan, Liang-Yin Chu, Wen-Fang Yuan
Publikováno v:
Expert Opinion on Drug Delivery. 16:207-218
As 'chemical antibodies', aptamers have some advantages, such as lack of immunogenicity, rapid tissue penetration, cell internalization and so on. Consequently, more and more aptamers have been screened out by the systematic evolution of ligands thro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc3ae6f15c3aaba89539c702ec27149
https://doi.org/10.1080/17425247.2019.1575808
https://doi.org/10.1080/17425247.2019.1575808
Publikováno v:
Molecular Medicine Reports. 23
Hepatic fibrosis (HF) is the process of fibrous scar formation caused by chronic liver injury of different etiologies. Previous studies have hypothesized that the activation of hepatic stellate cells (HSCs) is the central process in HF. The interacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75fb283531fa902bd63bd714316af872
https://doi.org/10.3892/mmr.2021.12003
https://doi.org/10.3892/mmr.2021.12003