Zobrazeno 1 - 10
of 330
pro vyhledávání: '"Wen Xing Ding"'
Publikováno v:
Livers, Vol 4, Iss 3, Pp 377-387 (2024)
Acetaminophen (APAP) overdose can induce hepatocyte necrosis and acute liver failure in experimental rodents and humans. APAP is mainly metabolized via hepatic cytochrome P450 enzymes to generate the highly reactive metabolite N-acetyl-p-benzoquinone
Externí odkaz:
https://doaj.org/article/64659b169e2942ee823e5360833d3c20
Autor:
Xiaojuan Chao, Mengwei Niu, Shaogui Wang, Xiaowen Ma, Xiao Yang, Hua Sun, Xujia Hu, Hua Wang, Li Zhang, Ruili Huang, Menghang Xia, Andrea Ballabio, Hartmut Jaeschke, Hong-Min Ni, Wen-Xing Ding
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 1, Pp 190-206 (2024)
Macroautophagy (referred to as autophagy hereafter) is a major intracellular lysosomal degradation pathway that is responsible for the degradation of misfolded/damaged proteins and organelles. Previous studies showed that autophagy protects against a
Externí odkaz:
https://doaj.org/article/4b0c2a33eb9b4262a2b3fc740c55ae0b
Publikováno v:
eGastroenterology, Vol 2, Iss 2 (2024)
Acute pancreatitis is a common inflammatory gastrointestinal disease without any successful treatment. Pancreatic exocrine acinar cells have high rates of protein synthesis to produce and secrete large amounts of digestive enzymes. When the regulatio
Externí odkaz:
https://doaj.org/article/e9275c82b7424962b7e58089c6f70b8a
Publikováno v:
eGastroenterology, Vol 2, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/da51176b3026436892c9c99d42f113ab
Autor:
Xiaowen Ma, Sharon Manley, Hui Qian, Yuan Li, Chen Zhang, Kevin Li, Benjamin Ding, Fengli Guo, Allen Chen, Xing Zhang, Meilian Liu, Meihua Hao, Benjamin Kugler, E. Matthew Morris, John Thyfault, Ling Yang, Hiromi Sesaki, Hong-Min Ni, Heidi McBride, Wen-Xing Ding
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113291- (2023)
Summary: Dysfunctional mitochondria are removed via multiple pathways, such as mitophagy, a selective autophagy process. Here, we identify an intracellular hybrid mitochondria-lysosome organelle (termed the mitochondria-lysosome-related organelle [ML
Externí odkaz:
https://doaj.org/article/bbdbea3ede7543fe881b4f46c6857cef
Autor:
Hui Qian, Xiaojuan Chao, Shaogui Wang, Yuan Li, Xiaoxiao Jiang, Zhaoli Sun, Thomas Rülicke, Kurt Zatloukal, Hong-Min Ni, Wen-Xing Ding
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 5, Pp 1027-1049 (2023)
Background: Alcohol-associated liver disease (ALD) is a worldwide health problem, of which the effective treatment is still lacking. Both detrimental and protective roles of adipose tissue have been implicated in ALD. Although alcohol increases adipo
Externí odkaz:
https://doaj.org/article/5da95cf1d2e54448a0f201e209fe9f08
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 143-160 (2022)
Equilibration of phospholipids between the two monolayers of the lipid bilayer of cellular membranes is mediated by scramblases acting as phospholipid shuttling proteins that are critical for cellular function, particularly during inter-organelle con
Externí odkaz:
https://doaj.org/article/d1bbf484a80f466986b3b9893f7e4d90
Autor:
David Matye, Sumedha Gunewardena, Jianglei Chen, Huaiwen Wang, Yifeng Wang, Mohammad Nazmul Hasan, Lijie Gu, Yung Dai Clayton, Yanhong Du, Cheng Chen, Jacob E. Friedman, Shelly C. Lu, Wen-Xing Ding, Tiangang Li
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Matye el al. show that coenzyme-A and glutathione deficiency in NAFLD limits fatty acid oxidation and antioxidant defence capacity. The nutrient sensing transcription factor EB induces autophagy–lysosome proteolysis and methionine cycle-transsulfur
Externí odkaz:
https://doaj.org/article/52ea7c8d29184987a1cfd046310b0ed5
Autor:
Hayden Weng Siong Tan, Guang Lu, Han Dong, Yik-Lam Cho, Auginia Natalia, Liming Wang, Charlene Chan, Dennis Kappei, Reshma Taneja, Shuo-Chien Ling, Huilin Shao, Shih-Yin Tsai, Wen-Xing Ding, Han-Ming Shen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The mechanisms underlying mitochondrial quality control are not fully understood. Here the authors identify a switch from degradative to secretory autophagy in the absence of the mATG8-conjugation system, termed Autophagic Secretion of Mitochondria.
Externí odkaz:
https://doaj.org/article/5faa98dd54e74eb38a71aec60636557b
Publikováno v:
Liver Research, Vol 6, Iss 1, Pp 50-57 (2022)
The 4th Chinese American Liver Society (CALS)/Society of Chinese Bioscientists in America (SCBA) Hepatology Division Annual Symposium was held virtually on October 29–30, 2021. The goal of the CALS Symposium was to present and discuss the recent re
Externí odkaz:
https://doaj.org/article/cfe02eaec6124436a1a4783855fe4a58