Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Wen Son Hsieh"'
Publikováno v:
Leukemia & Lymphoma. 63:2785-2794
Treatment of chronic lymphocytic leukemia (CLL) has been transformed in the past two decades. The introduction of targeted therapies has improved patient outcomes and the deliverability of effective therapies. Making the best use of the next wave of
Autor:
Won Young Tak, Chia-Jui Yen, Michael Jeffers, Heiko Krissel, Prabhu Rajagopalan, Christian Kappeler, Wen-Son Hsieh, Miah Hiang Tay, Joong-Won Park, Winnie Yeo, Ronnie T.P. Poon, Kun-Ming Rau, Chiun Hsu, Jung-Hwan Yoon, Cheng-Yao Lin, Hye Jin Choi, Jeong Heo, Ho Yeong Lim
Supplementary Figure 1. CONSORT diagram
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::180df5bebc37f2e679e0de974f8d88c2
https://doi.org/10.1158/1078-0432.22456302
https://doi.org/10.1158/1078-0432.22456302
Autor:
Won Young Tak, Chia-Jui Yen, Michael Jeffers, Heiko Krissel, Prabhu Rajagopalan, Christian Kappeler, Wen-Son Hsieh, Miah Hiang Tay, Joong-Won Park, Winnie Yeo, Ronnie T.P. Poon, Kun-Ming Rau, Chiun Hsu, Jung-Hwan Yoon, Cheng-Yao Lin, Hye Jin Choi, Jeong Heo, Ho Yeong Lim
Supplementary Tables. Supplementary Table 1. Pre-defined dose modification levels for sorafenib and refametinib Supplementary Table 2. Single-dose refametinib and its metabolite M17 geometric mean (% coefficient of variation) pharmacokinetic paramete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723652d45a76c05ae38d12a62f86e020
https://doi.org/10.1158/1078-0432.22456299.v1
https://doi.org/10.1158/1078-0432.22456299.v1
Autor:
Won Young Tak, Chia-Jui Yen, Michael Jeffers, Heiko Krissel, Prabhu Rajagopalan, Christian Kappeler, Wen-Son Hsieh, Miah Hiang Tay, Joong-Won Park, Winnie Yeo, Ronnie T.P. Poon, Kun-Ming Rau, Chiun Hsu, Jung-Hwan Yoon, Cheng-Yao Lin, Hye Jin Choi, Jeong Heo, Ho Yeong Lim
Purpose: There is an unmet need for treatment options in hepatocellular carcinoma (HCC). Sorafenib is currently the only approved systemic treatment for HCC. Refametinib, an oral, allosteric MEK inhibitor, has demonstrated antitumor activity in combi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b509ad041b38e29d2e64774f616fffaf
https://doi.org/10.1158/1078-0432.c.6523269
https://doi.org/10.1158/1078-0432.c.6523269
Autor:
Kiat Hon Lim, Kenneth Tou En Chang, Daniel Shao Weng Tan, Farid Mohamad, Brendan Nghee-Kheem Pang, Wen Son Hsieh, LeLe Aung, Iain Beehuat Tan, Shui Yen Soh, Hwai Loong Kong, Ross A. Soo, Su Pin Choo
Publikováno v:
Asia-Pacific journal of clinical oncology. 18(4)
The occurrence of neurotrophic tyrosine receptor kinase (NTRK) gene fusions in a wide range of tumor types presents an attractive opportunity for using a tropomyosin receptor kinase (TRK) inhibitor as cancer therapy. Recent clinical studies have demo
Autor:
Liang Kee Goh, Natalia Liem, Aadhitthya Vijayaraghavan, Gengbo Chen, Pei Li Lim, Kae-Jack Tay, Michelle Chang, John Soon Wah Low, Adita Joshi, Hong Hong Huang, Emarene Kalaw, Puay Hoon Tan, Wen-Son Hsieh, Wei Peng Yong, Joshi Alumkal, Hong Gee Sim
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91666 (2014)
We aimed to identify a prostate cancer DNA hypermethylation microarray signature (denoted as PHYMA) that differentiates prostate cancer from benign prostate hyperplasia (BPH), high from low-grade and lethal from non-lethal cancers. This is a non-rand
Externí odkaz:
https://doaj.org/article/d7fee0e656a4443f97c9947f46d69f2b
Autor:
Wen Son Hsieh, Guy Journo, John Soon Wah Low, Rena R. Xian, Meir Shamay, Yonatan Eran, Elinor Barzilai, Jennifer A. Kanakry, Richard F. Ambinder, Eldad J. Dann, Jennifer Stone, Netanel A. Horowitz, Wan Lu Woo, Anuj Ahuja
Publikováno v:
Blood Adv
Epstein-Barr virus (EBV) is associated with a variety of tumors and nonmalignant conditions. Latent EBV genomes in cells, including tumor cells, are often CpG methylated, whereas virion DNA is not CpG methylated. We demonstrate that methyl CpG bindin
Autor:
Li Ren Kong, Chwee Ming Lim, Gerhard Siemeister, Thomas Kwok Seng Loh, Nicholas Syn, Pei Li Lim, Boon Cher Goh, Andrea Li Ann Wong, Wen Son Hsieh, Lingzhi Wang
Publikováno v:
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy, Vol 3, Iss 1, Pp 1-9 (2018)
Signal Transduction and Targeted Therapy, Vol 3, Iss 1, Pp 1-9 (2018)
In addition to their canonical roles in regulating cell cycle transition and transcription, cyclin-dependent kinases (CDKs) have been shown to coordinate DNA damage response pathways, suggesting a rational pairing of CDK inhibitors with genotoxic che
Autor:
Dan Costin, Anjali Bharne, Benjamin Creelan, Ioana Bonta, Wen-Son Hsieh, Alexa B. Schrock, Vincent A. Miller, Sai-Hong Ignatius Ou, Petros Nikolinakos, Samuel J. Klempner, Viola W. Zhu, Jeffrey Silberberg, Thangavijayan Bosemani, Jeffrey S. Ross, Siraj M. Ali, Russell Madison
Publikováno v:
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 13(9)
Introduction We analyzed a large set of EGFR-mutated (EGFR+) NSCLC to identify and characterize cases with co-occurring kinase fusions as potential resistance mechanisms to EGFR tyrosine kinase inhibitors (TKIs). Methods EGFR+ (del 19, L858R, G719X,
Autor:
Anh Son Ho, Youichi Suzuki, Bui Khac Cuong, Naoki Yamamoto, Xin Liu, Akihide Ryo, Kenji Ohba, Wen Son Hsieh, Brendan Pang, Darren Qian Cheng Tan, Koji Ichiyama, Min Ye, LiFeng Zhang, Nguyen Linh Toan, Anand D. Jeyasekharan, Khay Guan Yeoh, Wee Joo Chng, Sanjay de Mel
Publikováno v:
Cancer Letters. 354:272-280
Through combining vaccine-derived measles and mumps viruses (MM), we efficiently targeted a wide range of hematopoietic cancer cell lines. MM synergistically killed many cell lines including acute myeloid leukemia (AML) cell lines. Further investigat