Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Wen Shu Wu"'
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113875- (2024)
Summary: Liver injury stimulates hepatocyte replication and hepatic stellate cell (HSC) activation, thereby driving liver regeneration. Aberrant HSC activation induces liver fibrosis. However, mechanisms underlying liver regeneration and fibrosis rem
Externí odkaz:
https://doaj.org/article/b2b79695c47c4a8bbdd79f4609a8adfd
Autor:
Yanwen Ge, Mei Hong, Yu Zhang, Jiachen Wang, Lei Li, Hongkai Zhu, Yue Sheng, Wen-Shu Wu, Zhonghui Zhang
Publikováno v:
Haematologica, Vol 109, Iss 2 (2023)
Leukemia stem cells (LSC) represent a crucial and rare subset of cells present in acute myeloid leukemia (AML); they play a pivotal role in the initiation, maintenance, and relapse of this disease. Targeting LSC holds great promise for preventing AML
Externí odkaz:
https://doaj.org/article/5da91afbc1284b53a40b082553db7699
LepRb+ cell–specific deletion of Slug mitigates obesity and nonalcoholic fatty liver disease in mice
Autor:
Min-Hyun Kim, Yuan Li, Qiantao Zheng, Lin Jiang, Martin G. Myers Jr., Wen-Shu Wu, Liangyou Rui
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 4 (2023)
Leptin exerts its biological actions by activating the long-form leptin receptor (LepRb). LepRb signaling impairment and leptin resistance are believed to cause obesity. The transcription factor Slug — also known as Snai2 — recruits epigenetic mo
Externí odkaz:
https://doaj.org/article/45d6f580bfb94b69a4f1eac66be0f531
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Muscle regeneration depends on self-renewal of muscle stem cells but how this is regulated on aging is unclear. Here, the authors identify Slug as regulating p16 Ink4a in quiescent muscle stem cells, and when Slug expression reduces in aged stem cell
Externí odkaz:
https://doaj.org/article/723f96fddfe440c2b28aee7a57cb3f10
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 7, Iss C, Pp 31-41 (2017)
Muscle stem cells (MuSCs) hold great therapeutic potential for muscle genetic disorders, such as Duchenne muscular dystrophy (DMD). The CRISP/Cas9-based genome editing is a promising technology for correcting genetic alterations in mutant genes. In t
Externí odkaz:
https://doaj.org/article/e8ab65205786447ca990a73143c0fed3
Autor:
Min-Hyun, Kim, Yuan, Li, Qiantao, Zheng, Lin, Jiang, Martin G, Myers, Wen-Shu, Wu, Liangyou, Rui
Publikováno v:
The Journal of clinical investigation.
Leptin exerts its biological actions by activating LepRb. LepRb signaling impairment and leptin resistance are believed to cause obesity. Transcription factor Slug (also known as Snai2) recruits epigenetic modifiers and regulates gene expression by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6963cc7c5eceedb973e57943573d3013
https://pubmed.ncbi.nlm.nih.gov/36512408
https://pubmed.ncbi.nlm.nih.gov/36512408
Autor:
Zhonghui Zhang, Yuanfan Hong, Di Xiang, Pei Zhu, Elise Wu, Wen Li, Jeffrey Mosenson, Wen-Shu Wu
Publikováno v:
Stem Cell Reports, Vol 4, Iss 4, Pp 645-657 (2015)
miR-302/367 is the most abundant miRNA cluster in human embryonic stem cells (hESCs) and can promote somatic cell reprogramming. However, its role in hESCs remains poorly understood. Here, we studied functional roles of the endogenous miR-302/367 clu
Externí odkaz:
https://doaj.org/article/013dbb6971ff45629f45dd80125bac16
Autor:
Zhijian Qian, Guoshu Yin, Pei Zhu, Hongyu Ni, Wen Shu Wu, Yalu Zhou, Lei Li, Yuanfan Hong, Chen Wu, Zhonghui Zhang
Publikováno v:
Leukemia
Leukemia stem cells (LSCs) are the rare populations of acute myeloid leukemia (AML) cells that are able to initiate, maintain, and propagate AML. Targeting LSCs is a promising approach for preventing AML relapse and improving long-term outcomes. Whil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3ac4262549642a9b46941a8a4864bcc
https://doi.org/10.1038/s41375-019-0566-x
https://doi.org/10.1038/s41375-019-0566-x
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications
Activation of the p16Ink4a-associated senescence pathway during aging breaks muscle homeostasis and causes degenerative muscle disease by irreversibly dampening satellite cell (SC) self-renewal capacity. Here, we report that the zinc-finger transcrip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5785f4ae61aa4eae43fc1f6af49ba4
http://link.springer.com/article/10.1038/s41467-019-10479-4
http://link.springer.com/article/10.1038/s41467-019-10479-4
Autor:
Stefan Heinrichs, Lillian F Conover, Carlos E Bueso-Ramos, Outi Kilpivaara, Kristen Stevenson, Donna Neuberg, Mignon L Loh, Wen-Shu Wu, Scott J Rodig, Guillermo Garcia-Manero, Hagop M Kantarjian, A Thomas Look
Publikováno v:
eLife, Vol 2 (2013)
A common deleted region (CDR) in both myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN) affects the long arm of chromosome 20 and has been predicted to harbor a tumor suppressor gene. Here we show that MYBL2, a gene within the 20
Externí odkaz:
https://doaj.org/article/c12e1a435cb34c22b79ccdb8bbb2163e