Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Wen S. Sheng"'
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106628- (2023)
Summary: This study was undertaken to investigate the role of CD4+FoxP3+ regulatory T cells (Tregs) in regulating neuroinflammation during viral Ag-challenge and re-challenge. CD8+ lymphocytes persisting within tissues are designated tissue-resident
Externí odkaz:
https://doaj.org/article/6293e5255c1b4d87ab2df117cc2454c7
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Upon reactivation of quiescent neurotropic viruses antigen (Ag)-specific brain resident-memory CD8+ T-cells (bTRM) may respond to de novo-produced viral Ag through the rapid release of IFN-γ, which drives subsequent interferon-stimulated gene expres
Externí odkaz:
https://doaj.org/article/d76853a23004469fbd8d83fbb15f5763
Publikováno v:
iScience, Vol 20, Iss , Pp 512-526 (2019)
Summary: HIV-associated neurocognitive disorders (HAND) persist even during effective combination antiretroviral therapy (cART). Although the cause of HAND is unknown, studies link chronic immune activation, neuroinflammation, and cerebrospinal fluid
Externí odkaz:
https://doaj.org/article/77393c6bd5074b1ea67604feff0aacee
Publikováno v:
Cells, Vol 11, Iss 18, p 2826 (2022)
Regulatory T-cells (Tregs) play pivotal roles during infection, cancer, and autoimmunity. In our previous study, we demonstrated a role for the PD-1:PD-L1 pathway in controlling cytolytic responses of CD8+ T lymphocytes against microglial cells prese
Externí odkaz:
https://doaj.org/article/5fc5f10e7d6147e3a95be63d78b8e5d7
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-16 (2018)
Abstract Background Peripheral neuropathy is currently the most common neurological complication in HIV-infected individuals, occurring in 35–50% of patients undergoing combination anti-retroviral therapy. Data have shown that distal symmetric poly
Externí odkaz:
https://doaj.org/article/b47ed7d07c6e49d0bd1617e471317715
Publikováno v:
Brain Sciences, Vol 11, Iss 11, p 1482 (2021)
The role of select pro- and anti-inflammatory mediators in driving microglial cell polarization into classically (M1), or alternatively, (M2) activated states, as well as the subsequent differential responses of these induced phenotypes, was examined
Externí odkaz:
https://doaj.org/article/917a425cb0ef40cd92bcca0d27ca452f
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-13 (2017)
Abstract Background Previous work from our laboratory has demonstrated that during acute viral brain infection, glial cells modulate antiviral T cell effector responses through the PD-1: PD-L1 pathway, thereby limiting the deleterious consequences of
Externí odkaz:
https://doaj.org/article/a31246895576425f9fa0b09dc08a9c35
Publikováno v:
Pain Research and Management, Vol 2019 (2019)
The most common neurological complication in patients receiving successful combination antiretroviral therapy (cART) is peripheral neuropathic pain. Data show that distal symmetric polyneuropathy (DSP) also develops along with murine acquired immunod
Externí odkaz:
https://doaj.org/article/b4f2ef237ad742e6bc095300abc63009
Publikováno v:
Glia
Microglial cells are the main reservoir for HIV-1 within the brain and potential exists for negative immune checkpoint blockade therapies to purge this viral reservoir. Here, we investigated cytolytic responses of CD8(+) T lymphocytes against microgl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce65c0aa8600695645e955d9d6b3ad1e
https://doi.org/10.1002/glia.23932
https://doi.org/10.1002/glia.23932
Publikováno v:
Brain Sciences
Volume 11
Issue 11
Brain Sciences, Vol 11, Iss 1482, p 1482 (2021)
Volume 11
Issue 11
Brain Sciences, Vol 11, Iss 1482, p 1482 (2021)
The role of select pro- and anti-inflammatory mediators in driving microglial cell polarization into classically (M1), or alternatively, (M2) activated states, as well as the subsequent differential responses of these induced phenotypes, was examined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2863e36a97fd7430c2f2dc9a31b6d182