Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Wen Ji Chen"'
Autor:
Yong Jian Zhou, Wen Ji Chen, Yanlei Du, Hui Ting Chen, Chuang Yu Cao, Yu Yuan Li, Yu Qiang Nie, Bing Cai
Publikováno v:
Journal of Digestive Diseases. 17:829-836
Objective To investigate the role of adiponectin precursor (ADIPOQ) DNA methylation in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and the effect of curcumin on the development of NAFLD using rat models. Methods Male Sprague–Dawley
Autor:
Earnest Horne, Janet H. Parham, Christine R. Hoffman, Byron Ellis, Jane Bynum, Sue H. Kadwell, Kevin Blackburn, Wen-Ji Chen, Thomas G. Consler, Derril H. Willard, Marie A. Iannone, George Barrett
Publikováno v:
Protein Expression and Purification. 20:48-57
Receptor activator of NF-kappaB ligand (RANKL) is a type II transmembrane protein found on osteoblasts which functions as a major determinant of osteoclast differentiation and activation. RANKL mediates bone homeostasis through binding to the cognate
Autor:
Laurie K. Overton, A. Smith, Wen Ji Chen, C. J. Marshall, Octerloney B. McDonald, Edgar R. Wood, M. Rink, Byron Ellis, Christine R. Hoffman
Publikováno v:
Analytical Biochemistry. 268:318-329
We have developed a quantitative scintillation proximity assay (SPA) that reproduces the Raf/MEK/ERK signal transduction pathway. The components of this assay include human cRaf1, MEK1, and ERK2 and a biotinylated peptide substrate for ERK2. cRaf1 wa
Autor:
William D. Holmes, Michael A. Luther, Susan Armour, Channa K Jayawickreme, Grace Chen, Larry Boone, Wen Ji Chen, Walter S. Dallas, Robert G. Ferris, Chris Watson, Larry Wolfe, Terry P. Kenakin
Publikováno v:
Molecular Pharmacology. 53:177-181
This article describes the transient expression of the CXC chemokine receptor-4 in Xenopus laevis melanophores and the resulting functional assay for the endogenous ligand for this receptor stromal cell-derived factor (SDF)-1alpha. Specifically, it w
Autor:
Wen-Ji Chen, William O. Wilkison, Yvon C. Chagnon, André Nadeau, Louis Pérusse, Claude Bouchard, Monique Chagnon
Publikováno v:
Molecular Medicine. 3:663-673
The agouti yellow mouse shows adult onset of moderate obesity and diabetes. A depressed basal lipolytic rate in adipocytes or a decreased adrenergic tone arising from antagonizing α-melanocyte-stimulating hormone (MSH) activation of melanocortin rec
Autor:
Jessica E. Matthews, Wen-Ji Chen, Kerry J Koller, Richard F. Cox, Alejandro J. Daniels, Donald Lyerly, Marilyn Jansen
Publikováno v:
Regulatory Peptides. 72:113-119
Neuropeptide Y (NPY) is widely distributed throughout the central and peripheral nervous system and exerts a wide range of physiological responses by activating specific receptors. In this study we have characterized the potency of the high affinity
Autor:
John G. Gray, John P. Cogswell, Kelly S. Lewis, Sandra W. Stinnett, Wen-Ji Chen, Gyan Chandra, Sue H. Kadwell
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1264:388-396
In this report we described the isolation of transcription factor E4BP4 by lambda gt11 expression cloning using a probe containing the CRE/ATF-like sequence located between -2764 bp and -2753 bp in the upstream regulatory region for the human IL-1 be
Autor:
Richard P. Woychik, Ingo Hansmann, Paul J. Furdon, John G. Powell, Wen Ji Chen, Scott J. Bultman, Heajoon Y. Kwon, William O. Wilkison, Christiane Löffler, Anton-Lewis Usala
Publikováno v:
Proceedings of the National Academy of Sciences. 91:9760-9764
The agouti (a) locus in mouse chromosome 2 normally regulates coat color pigmentation. The mouse agouti gene was recently cloned and shown to encode a distinctive 131-amino acid protein with a consensus signal peptide. Here we describe the cloning of
Publikováno v:
Journal of Biological Chemistry. 268:9675-9680
The mammalian enzyme protein farnesyltransferase is a heterodimeric protein that catalyzes the addition of a farnesyl isoprenoid to a cysteine in ras proteins. Since oncogenic forms of ras proteins require the farnesyl group for transforming activity
Autor:
Jide Wang, Victoria P Y Tan, Bing Zou, Colin S.C. Lam, Hui-Yao Lan, Ivan Hung, Juan Ma, Wenjing Zhang, Wen-Ji Chen, Benjamin C.Y. Wong, Roberta Pang, Minhu Chen, Qi-Yi Wang
Publikováno v:
Carcinogenesis. 31(9)
Background and Aims: The expression of pancreatic-duodenal homeobox 1 (PDX1) in gastric cancer is aberrantly reduced. The aim of this study was to elucidate the regulation of DNA methylation and histone acetylation at the promoter for PDX1 silencing