IκBα controls dormancy in hematopoietic stem cells via retinoic acid during embryonic development

Autor: Roshana Thambyrajah, Maria Maqueda, Muhammad Zaki Fadlullah, Martin Proffitt, Wen Hao Neo, Yolanda Guillén, Marta Casado-Pelaez, Patricia Herrero-Molinero, Carla Brujas, Noemi Castelluccio, Jessica González, Arnau Iglesias, Laura Marruecos, Cristina Ruiz-Herguido, Manel Esteller, Elisabetta Mereu, Georges Lacaud, Lluis Espinosa, Anna Bigas

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract Recent findings suggest that Hematopoietic Stem Cells (HSC) and progenitors arise simultaneously and independently of each other already in the embryonic aorta-gonad mesonephros region, but it is still unknown how their different features ar

Externí odkaz: https://doaj.org/article/e2c4801c11ca4edbbdc98a6129f4d110

Ezh2 is essential for the generation of functional yolk sac derived erythro-myeloid progenitors

Autor: Wen Hao Neo, Yiran Meng, Alba Rodriguez-Meira, Muhammad Z. H. Fadlullah, Christopher A. G. Booth, Emanuele Azzoni, Supat Thongjuea, Marella F. T. R. de Bruijn, Sten Eirik W. Jacobsen, Adam J. Mead, Georges Lacaud

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

Yolk sac erythro-myeloid progenitors (EMPs) are critical for embryo viability and a major source of adult tissue-resident macrophages. Here, the authors show an essential stage-specific role for Ezh2 in modulating Wnt signaling during EMP generation.

Externí odkaz: https://doaj.org/article/ed0b6a3fcda745e28ef592ad042e36dd

Cell-intrinsic depletion of Aml1-ETO-expressing pre-leukemic hematopoietic stem cells by K-Ras activating mutation

Autor: Cristina Di Genua, Ruggiero Norfo, Alba Rodriguez-Meira, Wei Xiong Wen, Roy Drissen, Christopher A.G. Booth, Benjamin Povinelli, Emmanouela Repapi, Nicki Gray, Joana Carrelha, Laura M. Kettyle, Lauren Jamieson, Wen Hao Neo, Supat Thongjuea, Claus Nerlov, Adam J. Mead

Publikováno v: Haematologica, Vol 104, Iss 11 (2019)

Somatic mutations in acute myeloid leukemia are acquired sequentially and hierarchically. First, pre-leukemic mutations, such as t(8;21) that encodes AML1-ETO, are acquired within the hematopoietic stem cell (HSC) compartment, while signaling pathway

Externí odkaz: https://doaj.org/article/63c14c0940654124844eb28a1e97c816

Murine AGM single-cell profiling identifies a continuum of hemogenic endothelium differentiation marked by ACE

Autor: Georges Lacaud, Pierre Savatier, Renaud Mevel, Syed Murtuza Baker, Irene Aksoy, Wen Hao Neo, Rahima Patel, Valerie Kouskoff, Magnus Rattray, Laura Fontenille, Roshana Thambyrajah, Nam Do Khoa, Muhammad Zaki Hidayatullah Fadlullah, Michael Lie-A-Ling

Publikováno v: Fadlullah, M Z H, Neo, W H, Lie-a-ling, M, Thambyrajah, R, Patel, R, Mevel, R, Aksoy, I, Do Khoa, N, Savatier, P, Fontenille, L, Baker, S M, Rattray, M, Kouskoff, V & Lacaud, G 2022, ' Murine AGM single-cell profiling identifies a continuum of hemogenic endothelium differentiation marked by ACE ', Blood, vol. 139, no. 3, pp. 343-356 . https://doi.org/10.1182/blood.2020007885, https://doi.org/10.1182/blood.2020007885

In vitro generation and expansion of hematopoietic stem cells (HSCs) holds great promise for the treatment of any ailment that relies on bone marrow or blood transplantation. To achieve this, it is essential to resolve the molecular and cellular path

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915a20e90ef52787d2fbf9f575e922b5
https://doi.org/10.1182/blood.2020007885

Contributions of Embryonic HSC-Independent Hematopoiesis to Organogenesis and the Adult Hematopoietic System

Autor: Muhammad Zaki Hidayatullah Fadlullah, Georges Lacaud, Wen Hao Neo, Michael Lie-A-Ling

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology

During ontogeny, the establishment of the hematopoietic system takes place in several phases, separated both in time and location. The process is initiated extra-embryonically in the yolk sac (YS) and concludes in the main arteries of the embryo with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746865cf4e80c4e145dd13b006685072