A genome-wide association search for type 2 diabetes genes in African Americans.

Autor: Nicholette D Palmer, Caitrin W McDonough, Pamela J Hicks, Bong H Roh, Maria R Wing, S Sandy An, Jessica M Hester, Jessica N Cooke, Meredith A Bostrom, Megan E Rudock, Matthew E Talbert, Joshua P Lewis, DIAGRAM Consortium, MAGIC Investigators, Assiamira Ferrara, Lingyi Lu, Julie T Ziegler, Michele M Sale, Jasmin Divers, Daniel Shriner, Adebowale Adeyemo, Charles N Rotimi, Maggie C Y Ng, Carl D Langefeld, Barry I Freedman, Donald W Bowden, Benjamin F Voight, Laura J Scott, Valgerdur Steinthorsdottir, Andrew P Morris, Christian Dina, Ryan P Welch, Eleftheria Zeggini, Cornelia Huth, Yurii S Aulchenko, Gudmar Thorleifsson, Laura J McCulloch, Teresa Ferreira, Harald Grallert, Najaf Amin, Guanming Wu, Cristen J Willer, Soumya Raychaudhuri, Steve A McCarroll, Claudia Langenberg, Oliver M Hofmann, Josée Dupuis, Lu Qi, Ayellet V Segrè, Mandy van Hoek, Pau Navarro, Kristin Ardlie, Beverley Balkau, Rafn Benediktsson, Amanda J Bennett, Roza Blagieva, Eric Boerwinkle, Lori L Bonnycastle, Kristina Bengtsson Boström, Bert Bravenboer, Suzannah Bumpstead, Noël P Burtt, Guillaume Charpentier, Peter S Chines, Marilyn Cornelis, David J Couper, Gabe Crawford, Alex S F Doney, Katherine S Elliott, Amanda L Elliott, Michael R Erdos, Caroline S Fox, Christopher S Franklin, Martha Ganser, Christian Gieger, Niels Grarup, Todd Green, Simon Griffin, Christopher J Groves, Candace Guiducci, Samy Hadjadj, Neelam Hassanali, Christian Herder, Bo Isomaa, Anne U Jackson, Paul R V Johnson, Torben Jørgensen, Wen H L Kao, Norman Klopp, Augustine Kong, Peter Kraft, Johanna Kuusisto, Torsten Lauritzen, Man Li, Aloysius Lieverse, Cecilia M Lindgren, Valeriya Lyssenko, Michel Marre, Thomas Meitinger, Kristian Midthjell, Mario A Morken, Narisu Narisu, Peter Nilsson, Katharine R Owen, Felicity Payne, John R B Perry, Ann-Kristin Petersen, Carl Platou, Christine Proença, Inga Prokopenko, Wolfgang Rathmann, N William Rayner, Neil R Robertson, Ghislain Rocheleau, Michael Roden, Michael J Sampson, Richa Saxena, Beverley M Shields, Peter Shrader, Gunnar Sigurdsson, Thomas Sparsø, Klaus Strassburger, Heather M Stringham, Qi Sun, Amy J Swift, Barbara Thorand, Jean Tichet, Tiinamaija Tuomi, Rob M van Dam, Timon W van Haeften, Thijs van Herpt, Jana V van Vliet-Ostaptchouk, G Bragi Walters, Michael N Weedon, Cisca Wijmenga, Jacqueline Witteman, Richard N Bergman, Stephane Cauchi, Francis S Collins, Anna L Gloyn, Ulf Gyllensten, Torben Hansen, Winston A Hide, Graham A Hitman, Albert Hofman, David J Hunter, Kristian Hveem, Markku Laakso, Karen L Mohlke, Andrew D Morris, Colin N A Palmer, Peter P Pramstaller, Igor Rudan, Eric Sijbrands, Lincoln D Stein, Jaakko Tuomilehto, Andre Uitterlinden, Mark Walker, Nicholas J Wareham, Richard M Watanabe, Goncalo R Abecasis, Bernhard O Boehm, Harry Campbell, Mark J Daly, Andrew T Hattersley, Frank B Hu, James B Meigs, James S Pankow, Oluf Pedersen, H-Erich Wichmann, Inês Barroso, Jose C Florez, Timothy M Frayling, Leif Groop, Rob Sladek, Unnur Thorsteinsdottir, James F Wilson, Thomas Illig, Philippe Froguel, Cornelia M van Duijn, Kari Stefansson, David Altshuler, Michael Boehnke, Mark I McCarthy, Nicole Soranzo, Eleanor Wheeler, Nicole L Glazer, Nabila Bouatia-Naji, Reedik Mägi, Joshua Randall, Toby Johnson, Paul Elliott, Denis Rybin, Peter Henneman, Abbas Dehghan, Jouke Jan Hottenga, Kijoung Song, Anuj Goel, Josephine M Egan, Taina Lajunen, Alex Doney, Stavroula Kanoni, Christine Cavalcanti-Proença, Meena Kumari, Nicholas J Timpson, Carina Zabena, Erik Ingelsson, Ping An, Jeffrey O'Connell, Jian'an Luan, Amanda Elliott, Steven A McCarroll, Rosa Maria Roccasecca, François Pattou, Praveen Sethupathy, Yavuz Ariyurek, Philip Barter, John P Beilby, Yoav Ben-Shlomo, Sven Bergmann, Murielle Bochud, Amélie Bonnefond, Knut Borch-Johnsen, Yvonne Böttcher, Eric Brunner, Suzannah J Bumpstead, Yii-Der Ida Chen, Peter Chines, Robert Clarke, Lachlan J M Coin, Matthew N Cooper, Laura Crisponi, Ian N M Day, Eco J C de Geus, Jerome Delplanque, Annette C Fedson, Antje Fischer-Rosinsky, Nita G Forouhi, Rune Frants, Maria Grazia Franzosi, Pilar Galan, Mark O Goodarzi, Jürgen Graessler, Scott Grundy, Rhian Gwilliam, Göran Hallmans, Naomi Hammond, Xijing Han, Anna-Liisa Hartikainen, Caroline Hayward, Simon C Heath, Serge Hercberg, Andrew A Hicks, David R Hillman, Aroon D Hingorani, Jennie Hui, Joe Hung, Antti Jula, Marika Kaakinen, Jaakko Kaprio, Y Antero Kesaniemi, Mika Kivimaki, Beatrice Knight, Seppo Koskinen, Peter Kovacs, Kirsten Ohm Kyvik, G Mark Lathrop, Debbie A Lawlor, Olivier Le Bacquer, Cécile Lecoeur, Yun Li, Robert Mahley, Massimo Mangino, Alisa K Manning, María Teresa Martínez-Larrad, Jarred B McAteer, Ruth McPherson, Christa Meisinger, David Melzer, David Meyre, Braxton D Mitchell, Sutapa Mukherjee, Silvia Naitza, Matthew J Neville, Ben A Oostra, Marco Orrù, Ruth Pakyz, Giuseppe Paolisso, Cristian Pattaro, Daniel Pearson, John F Peden, Nancy L Pedersen, Markus Perola, Andreas F H Pfeiffer, Irene Pichler, Ozren Polasek, Danielle Posthuma, Simon C Potter, Anneli Pouta, Michael A Province, Bruce M Psaty, Nigel W Rayner, Kenneth Rice, Samuli Ripatti, Fernando Rivadeneira, Olov Rolandsson, Annelli Sandbaek, Manjinder Sandhu, Serena Sanna, Avan Aihie Sayer, Paul Scheet, Udo Seedorf, Stephen J Sharp, Beverley Shields, Eric J G Sijbrands, Angela Silveira, Laila Simpson, Andrew Singleton, Nicholas L Smith, Ulla Sovio, Amy Swift, Holly Syddall, Ann-Christine Syvänen, Toshiko Tanaka, Anke Tönjes, André G Uitterlinden, Ko Willems van Dijk, Dhiraj Varma, Sophie Visvikis-Siest, Veronique Vitart, Nicole Vogelzangs, Gérard Waeber, Peter J Wagner, Andrew Walley, Kim L Ward, Hugh Watkins, Sarah H Wild, Gonneke Willemsen, Jaqueline C M Witteman, John W G Yarnell, Diana Zelenika, Björn Zethelius, Guangju Zhai, Jing Hua Zhao, M Carola Zillikens, Ingrid B Borecki, Ruth J F Loos, Pierre Meneton, Patrik K E Magnusson, David M Nathan, Gordon H Williams, Kaisa Silander, Veikko Salomaa, George Davey Smith, Stefan R Bornstein, Peter Schwarz, Joachim Spranger, Fredrik Karpe, Alan R Shuldiner, Cyrus Cooper, George V Dedoussis, Manuel Serrano-Ríos, Lars Lind, Lyle J Palmer, Paul W Franks, Shah Ebrahim, Michael Marmot, W H Linda Kao, Peter Paul Pramstaller, Alan F Wright, Michael Stumvoll, Anders Hamsten, Thomas A Buchanan, Timo T Valle, Jerome I Rotter, David S Siscovick, Brenda W J H Penninx, Dorret I Boomsma, Panos Deloukas, Timothy D Spector, Luigi Ferrucci, Antonio Cao, Angelo Scuteri, David Schlessinger, Manuela Uda, Aimo Ruokonen, Marjo-Riitta Jarvelin, Dawn M Waterworth, Peter Vollenweider, Leena Peltonen, Vincent Mooser, Robert Sladek

Publikováno v: PLoS ONE, Vol 7, Iss 1, p e29202 (2012)

African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African

Externí odkaz: https://doaj.org/article/73ab7f9637a040a28be2840650771705

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

Autor: Unnur Thorsteinsdottir, Carl G. P. Platou, Albert Hofman, Qi Sun, Narisu Narisu, Oliver Hofmann, Jean Tichet, Lu Qi, Jose C. Florez, H-Erich Wichmann, Peter Kraft, Leif Groop, Benjamin F. Voight, Wolfgang Rathmann, Francis S. Collins, Wen H. L. Kao, André G. Uitterlinden, Torben Hansen, James F. Wilson, Guanming Wu, Valgerdur Steinthorsdottir, Robert Sladek, Cornelia M. van Duijn, James B. Meigs, Philippe Froguel, Cristen J. Willer, Andrew D. Morris, Harry Campbell, Cecilia M. Lindgren, Igor Rudan, Josée Dupuis, Richard N. Bergman, Andrew T. Hattersley, Suzannah Bumpstead, Kristian Midthjell, Richard M. Watanabe, Kristina Bengtsson Boström, Eric J.G. Sijbrands, Mike Sampson, Thomas Meitinger, Graham A. Hitman, Amanda J. Bennett, Anna L. Gloyn, Ayellet V. Segrè, Mark I. McCarthy, Simon J. Griffin, Frank B. Hu, Kari Stefansson, Soumya Raychaudhuri, G. Bragi Walters, David Altshuler, Karen L. Mohlke, Michel Marre, Harald Grallert, Yurii S. Aulchenko, Bernhard O. Boehm, Aloysius G Lieverse, Christian Gieger, Samy Hadjadj, Kristin Ardlie, Man Li, Winston Hide, Caroline S. Fox, N P Burtt, Gonçalo R. Abecasis, Katharine R. Owen, Inês Barroso, Neil R. Robertson, Beverley M. Shields, Ulf Gyllensten, Torsten Lauritzen, Gabe Crawford, Claudia Langenberg, Martha Ganser, Bo Isomaa, Anne U. Jackson, Eleftheria Zeggini, Timon W. van Haeften, Jana V. van Vliet-Ostaptchouk, Rob M. van Dam, Richa Saxena, Ghislain Rocheleau, Mandy van Hoek, Niels Grarup, Cornelia Huth, Roza Blagieva, Christian Dina, Katherine S. Elliott, Rafn Benediktsson, Candace Guiducci, Barbara Thorand, Alex S. F. Doney, Najaf Amin, Christopher J. Groves, Gudmar Thorleifsson, Todd Green, Amy J. Swift, Klaus Strassburger, Paul Johnson, Johanna Kuusisto, Mark J. Daly, Jaakko Tuomilehto, Andrew P. Morris, David J. Hunter, Thomas Sparsø, N. William Rayner, Ann-Kristin Petersen, Pau Navarro, Norman Klopp, Jacqueline C. M. Witteman, Torben Jørgensen, Mark Walker, Eric Boerwinkle, Inga Prokopenko, Teresa Ferreira, Kristian Hveem, John R. B. Perry, Peter P. Pramstaller, James S. Pankow, Valeriya Lyssenko, Cisca Wijmenga, Lori L. Bonnycastle, Michael Roden, Felicity Payne, Timothy M. Frayling, Nicholas J. Wareham, Tiinamaija Tuomi, Heather M. Stringham, Mario A. Morken, Colin N. A. Palmer, Laura J. Scott, Thomas Illig, Guillaume Charpentier, Christian Herder, Lincoln Stein, Michael N. Weedon, Markku Laakso, Michael R. Erdos, Beverley Balkau, Augustine Kong, Neelam Hassanali, Steve McCarroll, Stéphane Cauchi, Michael Boehnke, David Couper, Peter M. Nilsson, Christopher S. Franklin, Marilyn C. Cornelis, Peter Shrader, Laura J. McCulloch, Oluf Pedersen, Peter S. Chines, Christine Proença, Thijs T. W. van Herpt, Amanda F. Elliott, Gunnar Sigurdsson, Bert Bravenboer, Ryan P. Welch

Publikováno v: Voight, B F, Scott, L J, Steinthorsdottir, V, Morris, A P, Dina, C, Welch, R P, Zeggini, E, Huth, C, Aulchenko, Y S, Thorleifsson, G, McCulloch, L J, Ferreira, T, Grallert, H, Amin, N, Wu, G, Willer, C J, Raychaudhuri, S, McCarroll, S A, Langenberg, C, Hofmann, O M, Dupuis, J, Qi, L, Segrè, A V, van Hoek, M, Navarro, P, Ardlie, K, Balkau, B, Benediktsson, R, Bennett, A J, Blagieva, R, Boerwinkle, E, Bonnycastle, L L, Bengtsson Boström, K, Bravenboer, B, Bumpstead, S, Burtt, N P, Charpentier, G, Chines, P S, Cornelis, M, Couper, D J, Crawford, G, Doney, A S F, Elliott, K S, Elliott, A L, Erdos, M R, Fox, C S, Franklin, C S, Ganser, M, Gieger, C, Lauritzen, T & MAGIC Investigators 2010, ' Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis ', Nature Genetics, vol. 42, no. 7, pp. 579-89 . https://doi.org/10.1038/ng.609
Nature Genetics, 42(7), 579-U155. Nature Publishing Group
Nature Genetics; Vol 42
Nature Genetics
Voight, B F, Scott, L J, Steinthorsdottir, V, Morris, A P, Dina, C, Welch, R P, Zeggini, E, Huth, C, Aulchenko, Y S, Thorleifsson, G, McCulloch, L, Ferreira, T, Grallert, H, Amin, N, Wu, G, Willer, C J, Raychaudhuri, S, McCarroll, S A, Langenberg, C, Hofmann, O M, Dupuis, J, Qi, L, Segre, A V, van Hoek, M, Navarro, P, Ardlie, K, Balkau, B, Benediktsson, R, Bennett, A J, Blagieva, R, Boerwinkle, E, Bonnycastle, L L, Bostrom, K B, Bravenboer, B, Bumpstead, S, Burtt, N P, Charpentier, G, Chines, P S, Cornelis, M, Couper, D J, Crawford, G, Doney, A S F, Elliott, K S, Elliott, A L, Erdos, M R, Fox, C S, Morris, A, Rudan, I & Campbell, H & Wilson, J F 2010, ' Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis ', Nature Genetics, vol. 42, no. 7, pp. 579-U155 . https://doi.org/10.1038/ng.609
Voight, B F, Scott, L J, Steinthorsdottir, V, Morris, A P, Dina, C, Welch, R P, Zeggini, E, Huth, C, Aulchenko, Y S, Thorleifsson, G, McCulloch, L J, Ferreira, T, Grallert, H, Amin, N, Wu, G, Willer, C J, Raychaudhuri, S, McCarroll, S A, Langenberg, C, Hofmann, O M, Dupuis, J, Qi, L, Segrè, A V, van Hoek, M, Navarro, P, Ardlie, K, Balkau, B, Benediktsson, R, Bennett, A J, Blagieva, R, Boerwinkle, E, Bonnycastle, L L, Bengtsson Boström, K, Bravenboer, B, Bumpstead, S, Burtt, N P, Charpentier, G, Chines, P S, Cornelis, M, Couper, D J, Crawford, G, Doney, A S F, Elliott, K S, Elliott, A L, Erdos, M R, Fox, C S, Franklin, C S, Ganser, M, Gieger, C, Hansen, T & MAGIC investigators 2010, ' Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis ', Nature Genetics, vol. 42, no. 7, pp. 579-89 . https://doi.org/10.1038/ng.609

By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we ident

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2322adb7316b9d8a037a9128044ed71
https://europepmc.org/articles/PMC3080658/