Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Wen Dun"'
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106830 (2014)
Because structural remodeling of several proteins, including ion channels, may underlie the abnormal action potentials of Purkinje cells (PCs) that survive in the 48 hr infarcted zone of the canine heart (IZPCs), we sought to determine the subcellula
Externí odkaz:
https://doaj.org/article/6c00919ca9974a5e83ae52ea27ef63f1
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78087 (2013)
Cardiac Na channel remodeling provides a critical substrate for generation of reentrant arrhythmias in border zones of the infarcted canine heart. Recent studies show that Nav1.5 assembly and function are linked to ankyrin-G, gap, and mechanical junc
Externí odkaz:
https://doaj.org/article/0a5405f05cf849acac5e999daa014736
Autor:
Matthew D Christensen, Wen Dun, Penelope A Boyden, Mark E Anderson, Peter J Mohler, Thomas J Hund
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 12, p e1000583 (2009)
Calmodulin kinase II (CaMKII) mediates critical signaling pathways responsible for divergent functions in the heart including calcium cycling, hypertrophy and apoptosis. Dysfunction in the CaMKII signaling pathway occurs in heart disease and is assoc
Externí odkaz:
https://doaj.org/article/0262aead4d844d6b9cfe94d9bc14eefd
Autor:
Arianne Papa, Sergey I. Zakharov, Alexander N. Katchman, Jared S. Kushner, Bi-xing Chen, Lin Yang, Guoxia Liu, Alejandro Sanchez Jimenez, Robyn J. Eisert, Gary A. Bradshaw, Wen Dun, Shah R. Ali, Aaron Rodriques, Karen Zhou, Veli Topkara, Mu Yang, John P. Morrow, Emily J. Tsai, Arthur Karlin, Elaine Wan, Marian Kalocsay, Geoffrey S. Pitt, Henry M. Colecraft, Manu Ben-Johny, Steven O. Marx
Publikováno v:
Nature Cardiovascular Research. 1:1022-1038
Fight-or-flight responses involve β-adrenergic-induced increases in heart rate and contractile force. In the present study, we uncover the primary mechanism underlying the heart’s innate contractile reserve. We show that four protein kinase A (PKA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d29a7152c7195aa5159ea1ac39befef0
https://doi.org/10.1038/s44161-022-00157-y
https://doi.org/10.1038/s44161-022-00157-y
Autor:
Arianne, Papa, Sergey I, Zakharov, Alexander N, Katchman, Jared S, Kushner, Bi-Xing, Chen, Lin, Yang, Guoxia, Liu, Alejandro Sanchez, Jimenez, Robyn J, Eisert, Gary A, Bradshaw, Wen, Dun, Shah R, Ali, Aaron, Rodriques, Karen, Zhou, Veli, Topkara, Mu, Yang, John P, Morrow, Emily J, Tsai, Arthur, Karlin, Elaine, Wan, Marian, Kalocsay, Geoffrey S, Pitt, Henry M, Colecraft, Manu, Ben-Johny, Steven O, Marx
Publikováno v:
Nature cardiovascular research. 1(11)
Fight-or-flight responses involve β-adrenergic-induced increases in heart rate and contractile force. In the present study, we uncover the primary mechanism underlying the heart's innate contractile reserve. We show that four protein kinase A (PKA)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::098eb2ff6d51588c62d0ba69760229f2
https://pubmed.ncbi.nlm.nih.gov/36424916
https://pubmed.ncbi.nlm.nih.gov/36424916
Publikováno v:
DASC/PiCom/CBDCom/CyberSciTech
The United States is the country of origin, advocacy and development of STEM education. Around 2012, the research on STEM education began to increase gradually in China's education circle. At present, STEM has become a hot word in China's K-12 stage.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57596c01c7479a3b0b3fc62cba66786c
https://doi.org/10.1109/dasc-picom-cbdcom-cyberscitech49142.2020.00068
https://doi.org/10.1109/dasc-picom-cbdcom-cyberscitech49142.2020.00068
Publikováno v:
Circulation Research. 127
Background: In HFpEF and PAH, men are more likely than women to develop right ventricular dysfunction (RVD) and die. Mechanisms underlying these sex differences are not well understood. In advanced HF patients, RVD is associated with RV fibrosis. Sex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db8aa0be910fe8ded06445df9884557f
https://doi.org/10.1161/res.127.suppl_1.545
https://doi.org/10.1161/res.127.suppl_1.545
Publikováno v:
Circulation Research. 127
Objectives: The nitric oxide (NO) receptor soluble guanylyl cyclase (GC-1) can localize to cell membrane microdomains, including caveolae. In failing hearts, GC-1 relocalizes away from caveolae and becomes oxidized. How this occurs is unknown. We hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::985d13e8ec12414a0da3e4d073968e78
https://doi.org/10.1161/res.127.suppl_1.546
https://doi.org/10.1161/res.127.suppl_1.546
Publikováno v:
Prog Biophys Mol Biol
This article reviews work over the past three decades that is related to the contribution of the pacemaker current, If, to basal and autonomically regulated spontaneous rate in the sinoatrial node. It also addresses how the actions of the pacemaker c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ac7b48fef59f8d98ba9d6fd74d56040
https://pubmed.ncbi.nlm.nih.gov/32853595
https://pubmed.ncbi.nlm.nih.gov/32853595
Publikováno v:
Life Sciences. 201:72-80
Cardiac Na+ channel remodeling provides a critical substrate for generation of reentrant arrhythmias in border zones of the infarcted canine heart. Recent studies show that Nav1.5 cytoskeletal- and endosomal-based membrane trafficking and function ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::279b5998ac5c057033e1304b5dcbe444
https://doi.org/10.1016/j.lfs.2018.03.024
https://doi.org/10.1016/j.lfs.2018.03.024