Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Wen Chun Juan"'
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95210 (2014)
Aberrant changes in the expression of the pro-apoptotic protein, BCL-2-like 11 (BIM), can result in either impaired or excessive apoptosis, which can contribute to tumorigenesis and degenerative disorders, respectively. Altering BIM pre-mRNA splicing
Externí odkaz:
https://doaj.org/article/ab6ee22127bd43098dd186bfd95f567d
Autor:
Judith L. Morgan, Xavier Roca, Kai Cheng, David E. Bergstrom, Tiffany Leidy-Davis, S. Tiong Ong, Leslie O. Goodwin, Wen Chun Juan
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Scientific Reports
Scientific Reports
Here, we describe an expansion of the typical DNA size limitations associated with CRISPR knock-in technology, more specifically, the physical extent to which mouse genomic DNA can be replaced with donor (in this case, human) DNA at an orthologous lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b30df2d0c783958f948db727c8d52a5
https://hdl.handle.net/10356/103397
https://hdl.handle.net/10356/103397
Autor:
Leslie O. Goodwin, Xavier Roca, Kai Cheng, Judith L. Morgan, Tiffany Leidy-Davis, David E. Bergstrom, Sin-Tiong Ong, Wen Chun Juan
Here, we describe an expansion of the DNA size limitations associated with CRISPR knock-in technology, more specifically, the physical extent to which mouse genomic DNA can be replaced with donor (in this case, human) DNA at an orthologous locus. Dri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::213e1852b1f17aedba525275125147c0
Autor:
Wen Chun Juan, Wanjin Hong
Publikováno v:
Genes, Vol 7, Iss 9, p 55 (2016)
Genes
Genes
The Hippo signaling pathway is a highly-conserved developmental pathway that plays an essential role in organ size control, tumor suppression, tissue regeneration and stem cell self-renewal. The YES-associated protein (YAP) and the transcriptional co
Autor:
Maxey C. M. Chung, Cynthia R. M. Y. Liang, Wei Wu, Wen Chun Juan, Jimmy Bok Yan So, Khay Guan Yeoh
Publikováno v:
PROTEOMICS - Clinical Applications. 6:152-162
Purpose We have mined the gastric fluid proteome for potential gastric cancer (GC) biomarkers that may enhance disease detection and facilitate prognostic monitoring. Experimental design In biomarker discovery, a total of 12 patient gastric fluid sam
Autor:
Xavier Roca, Wen Chun Juan, David E. Bergstrom, Sin-Tiong Ong, Tiffany Leidy-Davis, Judith L. Morgan, Leslie O. Goodwin, Kai Cheng
Publikováno v:
Cancer Research. 78:5097-5097
Here we describe an expansion of the DNA size limitations associated with CRISPR knock-in technology, more specifically, the physical extent to which mouse genomic DNA can be replaced with donor (in this case, human) DNA at an orthologous locus. Driv
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 4, p e95210 (2014)
PLoS ONE, Vol 9, Iss 4, p e95210 (2014)
Aberrant changes in the expression of the pro-apoptotic protein, BCL-2-like 11 (BIM), can result in either impaired or excessive apoptosis, which can contribute to tumorigenesis and degenerative disorders, respectively. Altering BIM pre-mRNA splicing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa181ee905b8a80299fe439b2f138a8e
https://hdl.handle.net/10356/104198
https://hdl.handle.net/10356/104198
Autor:
Wen Chun, Juan, S Tiong, Ong
Publikováno v:
Progress in molecular biology and translational science. 106
This review focuses on the central role that protein phosphorylation plays in the pathogenesis of chronic myelogenous leukemia (CML). It will cover the signaling pathways that are dysregulated by the oncogenic tyrosine kinase, BCR-ABL1, which both de
Autor:
Wen Chun Juan, S. Tiong Ong
This review focuses on the central role that protein phosphorylation plays in the pathogenesis of chronic myelogenous leukemia (CML). It will cover the signaling pathways that are dysregulated by the oncogenic tyrosine kinase, BCR-ABL1, which both de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3dc0ed4b779b753c061e24e1da2fa95
https://doi.org/10.1016/b978-0-12-396456-4.00007-9
https://doi.org/10.1016/b978-0-12-396456-4.00007-9
Autor:
Naoto Takahashi, V. S. Nadarajan, Yijun Ruan, Anbupalam Thalamuthu, Wing-Kin Sung, Xing Yi Woo, Hae Tha Mya, Sheila Soh, Xiaoan Ruan, Wen Chun Juan, Kazutoshi Isobe, Markus M. Nöthen, Wan-Teck Lim, John W.J. Huang, Hein Than, Yao Fei, L.Y. Yang, Chia-Tien Chang, Dianne Poh, Noan-Minh Chau, Axel M. Hillmer, Liang Piu Koh, Ai Leen Ang, Gee Fung How, Mei-Kim Ang, Yeow Tee Goh, Lay Cheng Lim, Tan Min Chin, Daniel Shao-Weng Tan, Wee Joo Chng, Balram Chowbay, Audrey S.M. Teo, Hiroyuki Mano, Ju Ee Seet, Niranjan Nagarajan, Quan Sing Ng, Shenli Zhang, Pramila N. Ariyaratne, Atif Shahab, Wan Ting Poh, Manabu Soda, Patrick Tan, Yasushi Yatabe, Kenichi Sawada, Vikrant Kumar, Ross A. Soo, Tien Yin Wong, Valere Cacheux-Rataboul, Charles Chuah, Eng Huat Tan, John Carson Allen, King Pan Ng, Wah Heng Lee, S. Tiong Ong, Tun Kiat Ko
Publikováno v:
Nature medicine. 18(4)
Tyrosine kinase inhibitors (TKIs) elicit high response rates among individuals with kinase-driven malignancies, including chronic myeloid leukemia (CML) and epidermal growth factor receptor-mutated non-small-cell lung cancer (EGFR NSCLC). However, th