Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Wen‐Wen Mu"'
Autor:
Ai-Ling Sun, Wen-Wen Mu, Yan-Mo Li, Ya-Lei Sun, Peng-Xiao Li, Ren-Min Liu, Jie Yang, Guo-Yun Liu
Publikováno v:
Molecules, Vol 26, Iss 11, p 3243 (2021)
Chemotherapeutic agents, which contain the Michael acceptor, are potent anticancer molecules by promoting intracellular reactive oxygen species (ROS) generation. In this study, we synthesized a panel of PL (piperlongumine) analogs with chlorine attac
Externí odkaz:
https://doaj.org/article/79bf19e78f994dc88a66f3c15def5a73
Publikováno v:
Pharmaceutical Chemistry Journal. 56:614-618
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::034e547dbb86a700d0cfc8689b3bde44
https://doi.org/10.1007/s11094-022-02685-0
https://doi.org/10.1007/s11094-022-02685-0
Publikováno v:
Monatshefte für Chemie - Chemical Monthly. 152:863-870
The hybrid approach, encompassing two pharmacophores in one molecular scaffold, has attracted much attention in medicinal chemistry. In this study, we synthesized a panel of hybrid molecules based on the natural active ingredients, β-ionone and 3,4,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::938d26ead1c49ea2523930f200615342
https://doi.org/10.1007/s00706-021-02799-3
https://doi.org/10.1007/s00706-021-02799-3
Publikováno v:
RSC Advances. 10:42128-42136
Piperlongumine (PL), a potent anticancer agent from the plant long pepper (Piper longum), contains the 5,6-dihydropyridin-2(1H)-one heterocyclic scaffold and cinnamoyl unit. In this paper, we synthesized a series of PL analogs and evaluated their cyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c542c9c5c6aec9e14ba7196a0f88a941
https://doi.org/10.1039/d0ra08778e
https://doi.org/10.1039/d0ra08778e
Publikováno v:
Chemistrybiodiversity. 19(2)
This work deals with the design and synthesis of 18 barbituric acid derivatives bearing 1,3-dimethylbarbituric acid and cinnamic acid scaffolds to find potent anticancer agents. The target molecules were obtained through Knoevenagel condensation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bec2c24b76490a42da4ecfbc11ed5c1
https://pubmed.ncbi.nlm.nih.gov/34931450
https://pubmed.ncbi.nlm.nih.gov/34931450
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 160
Curcumin was reported as an anti-inflammatory agent. However, curcumin's poor bioavailability limited its clinical utility. Here, thirty ortho-substituted mono-carbonyl curcumin derivatives, containing acetone, cyclopentanone, cyclohexanone or 4-pipe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc17f0ac1d5a5d2e392fc71cdca0fa1
https://pubmed.ncbi.nlm.nih.gov/33588045
https://pubmed.ncbi.nlm.nih.gov/33588045
Publikováno v:
Bioorganic chemistry. 104
β-ionone, a cyclic terpenoid compound present in many fruits, has been showed a broad spectrum of biological activities. In this paper, we synthesized a panel of β-ionone derivatives and tested their anti-proliferation activity on cancer cell by th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed4cf2639408e0a95384bcb9a9863521
https://pubmed.ncbi.nlm.nih.gov/32956875
https://pubmed.ncbi.nlm.nih.gov/32956875
Publikováno v:
Bioorganic Chemistry. 117:105465
Piperlongumine (PL) has been showed to have multiple pharmacological activities. In this study, we reported the synthesis of three series of PL derivatives, and evaluation of their anti-inflammatory effects in both lipopolysaccharide (LPS)-induced Ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f40fdaa111f5bc40d87bc6b5e212cb4
https://doi.org/10.1016/j.bioorg.2021.105465
https://doi.org/10.1016/j.bioorg.2021.105465
Autor:
Yan-Mo Li, Peng-Xiao Li, Renmin Liu, Ya-Lei Sun, Guo-Yun Liu, Ai-Ling Sun, Wen-Wen Mu, Jie Yang
Publikováno v:
Molecules, Vol 26, Iss 3243, p 3243 (2021)
Molecules
Volume 26
Issue 11
Molecules
Volume 26
Issue 11
Chemotherapeutic agents, which contain the Michael acceptor, are potent anticancer molecules by promoting intracellular reactive oxygen species (ROS) generation. In this study, we synthesized a panel of PL (piperlongumine) analogs with chlorine attac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d828f33e56f25b16804013b00712028f
https://doi.org/10.3390/molecules26113243
https://doi.org/10.3390/molecules26113243
Publikováno v:
European Journal of Pharmacology. 888:173396
Bischalcone has gained much attention because of its wide range of application in pharmaceutical chemistry. This work aims to evaluate the antiproliferation effects and explore the anticancer mechanism of bischalcone analogs on human lung cancer A549
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3951338d1eab05f5ceb07884c424935
https://doi.org/10.1016/j.ejphar.2020.173396
https://doi.org/10.1016/j.ejphar.2020.173396