Zobrazeno 1 - 10
of 243
pro vyhledávání: '"Wen‐Tai Chiu"'
Autor:
Yi-Shyun Lai, Meng-Ru Hsieh, Thi My Hang Nguyen, Ying-Chi Chen, Hsueh-Chun Wang, Wen-Tai Chiu
Publikováno v:
Open Biology, Vol 14, Iss 4 (2024)
Autophagy is a double-edged sword for cells; it can lead to both cell survival and death. Calcium (Ca2+) signalling plays a crucial role in regulating various cellular behaviours, including cell migration, proliferation and death. In this study, we i
Externí odkaz:
https://doaj.org/article/89b0421ce8934b1ab7d9c218102f6c98
Autor:
Heng-Ai Chang, Rui-Zhi Ou Yang, Jing-Ming Su, Thi My Hang Nguyen, Junne-Ming Sung, Ming-Jer Tang, Wen-Tai Chiu
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-14 (2023)
Abstract Maladaptive repair of acute kidney injury (AKI) is associated with a high risk of developing chronic kidney disease deemed irremediable even in present days. When AKI arises from ischemia-reperfusion injury, hypoxia usually plays a major rol
Externí odkaz:
https://doaj.org/article/629bdfffd96b4a3a9407dc9fbacd3fa9
Autor:
Thi My Hang Nguyen, Yi‐Shyun Lai, Ying‐Chi Chen, Tzu‐Chien Lin, Ngoc Thang Nguyen, Wen‐Tai Chiu
Publikováno v:
Cancer Medicine, Vol 12, Iss 8, Pp 9723-9737 (2023)
Abstract Background Hypoxia is commonly characterized by malignant tumors that promote the aggressiveness and metastatic potential of cancer. Triple‐negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, with approximately 4
Externí odkaz:
https://doaj.org/article/9a009a58010040e7b35eec9ff2bb0e2c
Autor:
Tzu-Chien Lin, Ping-Jung Chung, Chen-An Shen, Thi My Hang Nguyen, Yi-Syuan Lin, Shih-Chieh Lin, Shih-Chuan Hsiao, Wen-Tai Chiu
Publikováno v:
European Journal of Cell Biology, Vol 102, Iss 2, Pp 151332- (2023)
Intracellular calcium (Ca2+) has been reported to regulate transcription factor activity and cancer development, but how it affects the function of Forkhead box protein M1 (FOXM1), a crucial transcription factor and key oncogene participating in tumo
Externí odkaz:
https://doaj.org/article/b944f32868b040838e840f69fe1d4d82
Autor:
Yen-Chih Ho, Chen-Syun Ku, Siang-Sheng Tsai, Jia-Lin Shiu, Yi-Zhen Jiang, Hui Emmanuela Miriam, Han-Wen Zhang, Yen-Tzu Chen, Wen-Tai Chiu, Song-Bin Chang, Che-Hung Shen, Kyungjae Myung, Peter Chi, Hungjiun Liaw
Publikováno v:
PLoS Genetics, Vol 18, Iss 12, p e1010545 (2022)
Replication fork reversal which restrains DNA replication progression is an important protective mechanism in response to replication stress. PARP1 is recruited to stalled forks to restrain DNA replication. However, PARP1 has no helicase activity, an
Externí odkaz:
https://doaj.org/article/1c5222d02e6148d19c95d0967aeeb673
Autor:
Jia-Lin Shiu, Cheng-Kuei Wu, Song-Bin Chang, Yan-Jhih Sun, Yen-Ju Chen, Chien-Chen Lai, Wen-Tai Chiu, Wen-Tsan Chang, Kyungjae Myung, Wen-Pin Su, Hungjiun Liaw
Publikováno v:
Oncogenesis, Vol 9, Iss 12, Pp 1-14 (2020)
Abstract Human HLTF participates in the lesion-bypass mechanism through the fork reversal structure, known as template switching of post-replication repair. However, the mechanism by which HLTF promotes the replication progression and fork stability
Externí odkaz:
https://doaj.org/article/88f8fd3519004ed99af3d2198f271760
Autor:
Pai-Sheng Chen, Wen-Tai Chiu, Pei-Ling Hsu, Shih-Chieh Lin, I-Chen Peng, Chia-Yih Wang, Shaw-Jenq Tsai
Publikováno v:
Journal of Biomedical Science, Vol 27, Iss 1, Pp 1-19 (2020)
Abstract Oxygen is essentially required by most eukaryotic organisms as a scavenger to remove harmful electron and hydrogen ions or as a critical substrate to ensure the proper execution of enzymatic reactions. All nucleated cells can sense oxygen co
Externí odkaz:
https://doaj.org/article/cd8e712c9f3a4b0ab49d354459cb21f8
Autor:
Ho-Kai Huang, Yi-Hsin Lin, Heng-Ai Chang, Yi-Shyun Lai, Ying-Chi Chen, Soon-Cen Huang, Cheng-Yang Chou, Wen-Tai Chiu
Publikováno v:
Journal of Biomedical Science, Vol 27, Iss 1, Pp 1-14 (2020)
Abstract Background Among gynecological cancers, ovarian carcinoma has the highest mortality rate, and chemoresistance is highly prevalent in this cancer. Therefore, novel strategies are required to improve its poor prognosis. Formation and disassemb
Externí odkaz:
https://doaj.org/article/9fd37e45d1e6438ab24a6b603e50cc62
Autor:
Chi-Chin Sun, Shao-Yun Lee, Cheng-Heng Kao, Li-Hsien Chen, Zhao-Qing Shen, Chia-Hui Lai, Tsai-Yu Tzeng, Jong-Hwei Su Pang, Wen-Tai Chiu, Ting-Fen Tsai
Publikováno v:
EBioMedicine, Vol 73, Iss , Pp 103654- (2021)
Background: Age-related changes affecting the ocular surface cause vision loss in the elderly. Cisd2 deficiency drives premature aging in mice as well as resulting in various ocular surface abnormalities. Here we investigate the role of CISD2 in corn
Externí odkaz:
https://doaj.org/article/78376f21572c42f4975d2649ef8f3641
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Glioma, the most common subtype of primary brain tumor, is an aggressive and highly invasive neurologically tumor among human cancers. Interleukin-33 (IL-33) is considered as a dual functional cytokine, an alarmin upon tissue damage and a nuclear chr
Externí odkaz:
https://doaj.org/article/05b415e216834d6b8c62d4145e2c288c