Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Wen‐Chih Kuo"'
Autor:
Chien‐Min Hung, Wen‐Cheng Chu, Wen‐Yen Huang, Pei‐Jung Lee, Wen‐Chih Kuo, Cheng‐Yu Hou, Chia‐Chun Yang, Ai‐Jen Yang, Wei‐Kai Wu, Ming‐Liang Kuo, Ming‐Shiang Wu, Wan‐Jiun Chen
Publikováno v:
Food Science & Nutrition, Vol 12, Iss 4, Pp 2346-2363 (2024)
Abstract A safety evaluation was performed of Symbiota®, which is made by a proprietary anaerobic fermentation process of soybean with multistrains of probiotics and a yeast. The battery of genotoxicity studies showed that Symbiota® has no genotoxi
Externí odkaz:
https://doaj.org/article/97214512392e4fe6aec2c52d18286bb4
Autor:
Pei-Jung Lee, Chien-Min Hung, Ai-Jen Yang, Cheng-Yu Hou, Hung-Wen Chou, Yi-Chung Chang, Wen-Cheng Chu, Wen-Yen Huang, Wen-Chih Kuo, Chia-Chun Yang, Kuo-I Lin, Kuo-Hsuan Hung, Li-Chun Chang, Kang-Yun Lee, Han-Pin Kuo, Kung-Ming Lu, Hsin-Chih Lai, Ming-Liang Kuo, Wan-Jiun Chen
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
Cancer immunotherapy has been regarded as a promising strategy for cancer therapy by blocking immune checkpoints and evoking immunity to fight cancer, but its efficacy seems to be heterogeneous among patients. Manipulating the gut microbiota is a pot
Externí odkaz:
https://doaj.org/article/7f8c0ee5254a4cbab5db2b8cf0229d6f
Publikováno v:
Bioconjugate Chemistry. 31:1804-1811
Linker design is crucial to the success of antibody-drug conjugates (ADCs). In this work, we developed a modular linker format for attaching molecular cargos to antibodies based on strand pairing between complementary oligonucleotides. We prepared an
Autor:
Hong-Sen Chen, Shin-Chen Hou, Ya-Wen Chang, Wei Pang, Cheng-Chung Lee, An-Suei Yang, Shin-Yi Lo, Wen-Chih Kuo, Andrew H.-J. Wang
Publikováno v:
Journal of molecular biology. 433(4)
Interleukin-1β (IL-1β) is a potent pleiotropic cytokine playing a central role in protecting cells from microbial pathogen infection or endogenous stress. After it binds to IL-1RI and recruits IL-1 receptor accessory protein (IL-1RAcP), signaling c
Publikováno v:
Bioconjugate Chemistry; 7/15/2020, Vol. 31 Issue 7, p1804-1811, 8p
Publikováno v:
Biochemical Journal. 442:403-412
QC (glutaminyl cyclase) catalyses the formation of N-terminal pGlu (pyroglutamate) in peptides and proteins. pGlu formation in chemoattractants may participate in the regulation of macrophage activation and migration. However, a clear molecular mecha
Publikováno v:
Oncogene. 29:1374-1383
Ezrin links cortical actin filaments with the cell membrane, and has a critical role in many membrane-initiated events. Fas is directly associated with ezrin, but conflicting results have been reported for the involvement of ezrin in Fas-induced cell
Autor:
Kuo Ping Chiu, San Tai Shen, Chung Ming Yu, Sheng-Wei Lin, Ming Chi Peng, Shui Tsung Chen, An-Suei Yang, Shin-Chen Hou, King Siang Goh, Hung-Pin Peng, Chao Ping Tung, Jhong Jhe You, Andrew H.-J. Wang, Yu Ching Lee, Tzu Han Chen, Chih Yuan Wu, Hong Sen Chen, Wen Chih Kuo, Jhih-Wei Jian, Ing Chien Chen, Che Ma
Publikováno v:
Scientific Reports
Humoral immunity against diverse pathogens is rapidly elicited from natural antibody repertoires of limited complexity. But the organizing principles underlying the antibody repertoires that facilitate this immunity are not well-understood. We used H
Publikováno v:
Molecular Pharmacology. 66:1317-1324
GTP cyclohydrolase I (GCH) is the rate-controlling enzyme in the production of tetrahydrobiopterin (BH4) that is essential for the synthesis of nitric oxide and catecholamines including dopamine and serotonin. Therefore, the regulation of GCH express
Autor:
Ya-Ting Chuang, Yu-Hsun Lo, Hsiu Ming Shih, Yung-Hsuan Wu, Yu-Chuan Lin, Wen-Chih Kuo, Chi-Shan Tsai, Shu-Ting Mo, Yu-Wen Huang, Ming-Zong Lai, Si-Tse Jiang
Publikováno v:
Blood. 121(16)
The functional activities of the tumor suppressor promyelocytic leukemia protein (PML) are mostly associated with its nuclear location. In the present study, we discovered an unexpected role of PML in NLRP3 inflammasome activation. In PML-deficient m