Lack of Bmal1 leads to changes in rhythmicity and impairs motivation towards natural stimuli.

Autor: Berbegal-Sáez P; Department of Medicine and Life Sciences (MELIS), Neurobiology of Behaviour Research Group (GReNeC-NeuroBio), Universitat Pompeu Fabra, Barcelona, Spain., Gallego-Landin I; Department of Medicine and Life Sciences (MELIS), Neurobiology of Behaviour Research Group (GReNeC-NeuroBio), Universitat Pompeu Fabra, Barcelona, Spain., Macía J; Department of Medicine and Life Sciences (MELIS), Synthetic Biology for Biomedical Applications, Universitat Pompeu Fabra, Barcelona, Spain., Alegre-Zurano L; Department of Medicine and Life Sciences (MELIS), Neurobiology of Behaviour Research Group (GReNeC-NeuroBio), Universitat Pompeu Fabra, Barcelona, Spain., Castro-Zavala A; Department of Medicine and Life Sciences (MELIS), Neurobiology of Behaviour Research Group (GReNeC-NeuroBio), Universitat Pompeu Fabra, Barcelona, Spain., Welz PS; Program in Cancer Research, Hospital del Mar Research Institute (IMIM), Barcelona, Spain., Benitah SA; Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, Barcelon 08028, Spain.; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain., Valverde O; Department of Medicine and Life Sciences (MELIS), Neurobiology of Behaviour Research Group (GReNeC-NeuroBio), Universitat Pompeu Fabra, Barcelona, Spain.; Neuroscience Research Program, Hospital del Mar Research Institute (IMIM), Barcelona, Spain.

Publikováno v: Open biology [Open Biol] 2024 Jul; Vol. 14 (7), pp. 240051. Date of Electronic Publication: 2024 Jul 24.

Brain-muscle communication prevents muscle aging by maintaining daily physiology.

Autor: Kumar A; Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain., Vaca-Dempere M; Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain., Mortimer T; Institute for Research in Biomedicine (IRB), Barcelona, The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain., Deryagin O; Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain., Smith JG; Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain.; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA., Petrus P; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.; Department of Medicine (H7), Karolinska Institutet, Stockholm 141 86, Sweden., Koronowski KB; Department of Biochemistry & Structural Biology, Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX 78229, USA., Greco CM; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.; Department of Biomedical Sciences, Humanitas University and Humanitas Research Hospital IRCCS, 20089, Rozzano (Milan), Italy., Segalés J; Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain., Andrés E; Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain., Lukesova V; Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain., Zinna VM; Institute for Research in Biomedicine (IRB), Barcelona, The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain., Welz PS; Cancer Research Programme, Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain., Serrano AL; Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain.; Altos Labs Inc., San Diego Institute of Science, San Diego, CA 92121, USA., Perdiguero E; Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain.; Altos Labs Inc., San Diego Institute of Science, San Diego, CA 92121, USA., Sassone-Corsi P; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.; Deceased., Benitah SA; Institute for Research in Biomedicine (IRB), Barcelona, The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain.; Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Spain., Muñoz-Cánoves P; Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain.; Altos Labs Inc., San Diego Institute of Science, San Diego, CA 92121, USA.; Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Spain.

Publikováno v: Science (New York, N.Y.) [Science] 2024 May 03; Vol. 384 (6695), pp. 563-572. Date of Electronic Publication: 2024 May 02.

Liver and muscle circadian clocks cooperate to support glucose tolerance in mice.

Autor: Smith JG; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; Department of Medical and Life Sciences (MELIS), Pompeu Fabra University (UPF), Parc de Recerca Biomèdica de Barcelona (PRBB), 08003 Barcelona, Spain. Electronic address: jacob.smith@upf.edu., Koronowski KB; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, TX 78229, USA. Electronic address: koronowski@uthscsa.edu., Mortimer T; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain., Sato T; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka 422-8526, Japan., Greco CM; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele, Milan, Italy; IRCCS Humanitas Research Hospital, via Manzoni 56, 20089 Rozzano, Milan, Italy., Petrus P; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; Department of Medicine (H7), Karolinska Institutet, 141 86 Stockholm, Sweden., Verlande A; Department of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, CA 92697, USA., Chen S; Institute for Genomics and Bioinformatics, Department of Computer Science, University of California, Irvine, Irvine, CA 92697, USA., Samad M; Institute for Genomics and Bioinformatics, Department of Computer Science, University of California, Irvine, Irvine, CA 92697, USA., Deyneka E; Institute for Genomics and Bioinformatics, Department of Computer Science, University of California, Irvine, Irvine, CA 92697, USA., Mathur L; Department of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, CA 92697, USA., Blazev R; Centre for Muscle Research, Department of Anatomy and Physiology, The University of Melbourne, Melbourne, VIC 3010, Australia., Molendijk J; Centre for Muscle Research, Department of Anatomy and Physiology, The University of Melbourne, Melbourne, VIC 3010, Australia., Kumar A; Department of Medical and Life Sciences (MELIS), Pompeu Fabra University (UPF), Parc de Recerca Biomèdica de Barcelona (PRBB), 08003 Barcelona, Spain., Deryagin O; Department of Medical and Life Sciences (MELIS), Pompeu Fabra University (UPF), Parc de Recerca Biomèdica de Barcelona (PRBB), 08003 Barcelona, Spain., Vaca-Dempere M; Department of Medical and Life Sciences (MELIS), Pompeu Fabra University (UPF), Parc de Recerca Biomèdica de Barcelona (PRBB), 08003 Barcelona, Spain., Sica V; Department of Medical and Life Sciences (MELIS), Pompeu Fabra University (UPF), Parc de Recerca Biomèdica de Barcelona (PRBB), 08003 Barcelona, Spain., Liu P; King Abdullah University of Science and Technology, KAUST Environmental Epigenetics Research Program, Biological and Environmental Sciences and Engineering Division, Thuwal 23955, Saudi Arabia., Orlando V; King Abdullah University of Science and Technology, KAUST Environmental Epigenetics Research Program, Biological and Environmental Sciences and Engineering Division, Thuwal 23955, Saudi Arabia., Parker BL; Centre for Muscle Research, Department of Anatomy and Physiology, The University of Melbourne, Melbourne, VIC 3010, Australia., Baldi P; Institute for Genomics and Bioinformatics, Department of Computer Science, University of California, Irvine, Irvine, CA 92697, USA., Welz PS; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain; Program in Cancer Research, Hospital del Mar Medical Research Institute (IMIM), Parc de Recerca Biomèdica de Barcelona (PRBB), 08003 Barcelona, Spain., Jang C; Department of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, CA 92697, USA., Masri S; Department of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, CA 92697, USA., Benitah SA; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain; Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Spain. Electronic address: salvador.aznar-benitah@irbbarcelona.org., Muñoz-Cánoves P; Department of Medical and Life Sciences (MELIS), Pompeu Fabra University (UPF), Parc de Recerca Biomèdica de Barcelona (PRBB), 08003 Barcelona, Spain; Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Spain; Altos Labs, Inc., San Diego Institute of Science, San Diego, CA 92121, USA. Electronic address: pmunozcanoves@altoslabs.com., Sassone-Corsi P; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.

Publikováno v: Cell reports [Cell Rep] 2023 Jun 27; Vol. 42 (6), pp. 112588. Date of Electronic Publication: 2023 Jun 01.

The central clock suffices to drive the majority of circulatory metabolic rhythms.

Autor: Petrus P; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA., Smith JG; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.; Department of Experimental and Health Sciences, Pompeu Fabra University (UPF), CIBER on Neurodegenerative Diseases (CIBERNED), E-08003 Barcelona, Spain., Koronowski KB; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA., Chen S; Department of Computer Science, University of California, Irvine, Irvine, CA 92697, USA.; Institute for Genomics and Bioinformatics, University of California, Irvine, Irvine, CA 92697, USA., Sato T; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.; Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka 422-8526, Japan., Greco CM; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.; Department of Biomedical Sciences, Humanitas University and Humanitas Research Hospital IRCCS, Via Manzoni 56, 20089 Rozzano (Milan), Italy., Mortimer T; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain., Welz PS; Hospital del Mar Medical Research Institute (IMIM), Cancer Research Programme, 08003 Barcelona, Spain., Zinna VM; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain., Shimaji K; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA., Cervantes M; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA., Punzo D; School of Medicine, Department of Microbiology and Molecular Genetics, INSERMU1233, Center for Epigenetics and Metabolism, University of California, Irvine, Irvine, CA 92697, USA., Baldi P; Department of Computer Science, University of California, Irvine, Irvine, CA 92697, USA.; Institute for Genomics and Bioinformatics, University of California, Irvine, Irvine, CA 92697, USA., Muñoz-Cánoves P; Department of Experimental and Health Sciences, Pompeu Fabra University (UPF), CIBER on Neurodegenerative Diseases (CIBERNED), E-08003 Barcelona, Spain.; ICREA, Catalan Institution for Research and Advanced Studies, Barcelona, Spain.; Spanish National Center on Cardiovascular Research (CNIC), E-28029 Madrid, Spain., Sassone-Corsi P; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA., Benitah SA; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain.; Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Spain.

Publikováno v: Science advances [Sci Adv] 2022 Jul; Vol. 8 (26), pp. eabo2896. Date of Electronic Publication: 2022 Jun 29.

Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms.

Autor: Greco CM; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA., Koronowski KB; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA., Smith JG; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA., Shi J; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA., Kunderfranco P; Bioinformatics Unit, Humanitas Clinical and Research Center-IRCCS, Rozzano 20089, Italy., Carriero R; Bioinformatics Unit, Humanitas Clinical and Research Center-IRCCS, Rozzano 20089, Italy., Chen S; Institute for Genomics and Bioinformatics, Department of Computer Science, UCI, Irvine, CA 92697, USA., Samad M; Institute for Genomics and Bioinformatics, Department of Computer Science, UCI, Irvine, CA 92697, USA., Welz PS; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona 08028, Spain.; Program in Cancer Research, Hospital del Mar Medical Research Institute (IMIM), Dr. Aiguader 88, Barcelona 08003, Spain., Zinna VM; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona 08028, Spain., Mortimer T; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona 08028, Spain., Chun SK; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA., Shimaji K; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA., Sato T; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA., Petrus P; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA., Kumar A; Department of Experimental and Health Sciences, Pompeu Fabra University (UPF), CIBER on Neurodegenerative Diseases (CIBERNED), Barcelona 08003, Spain., Vaca-Dempere M; Department of Experimental and Health Sciences, Pompeu Fabra University (UPF), CIBER on Neurodegenerative Diseases (CIBERNED), Barcelona 08003, Spain., Deryagin O; Department of Experimental and Health Sciences, Pompeu Fabra University (UPF), CIBER on Neurodegenerative Diseases (CIBERNED), Barcelona 08003, Spain., Van C; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA., Kuhn JMM; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Computational Discovery Research, Institute for Diabetes and Obesity (IDO), Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München, Neuherberg, Germany., Lutter D; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Computational Discovery Research, Institute for Diabetes and Obesity (IDO), Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München, Neuherberg, Germany., Seldin MM; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA., Masri S; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA., Li W; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA., Baldi P; Institute for Genomics and Bioinformatics, Department of Computer Science, UCI, Irvine, CA 92697, USA., Dyar KA; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Metabolic Physiology, Institute for Diabetes and Cancer (IDC), Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany., Muñoz-Cánoves P; Department of Experimental and Health Sciences, Pompeu Fabra University (UPF), CIBER on Neurodegenerative Diseases (CIBERNED), Barcelona 08003, Spain.; Spanish National Center on Cardiovascular Research (CNIC), Madrid 28029, Spain.; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona 08010, Spain., Benitah SA; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona 08028, Spain.; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona 08010, Spain., Sassone-Corsi P; Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.

Publikováno v: Science advances [Sci Adv] 2021 Sep 24; Vol. 7 (39), pp. eabi7828. Date of Electronic Publication: 2021 Sep 22.