Inhibiting the NADase CD38 improves cytomegalovirus-specific CD8+ T cell functionality and metabolism.

Autor: Mülling N; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Nephrology, University Hospital Essen, University Duisburg-Essen, Essen, Germany., Behr FM; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands., Heieis GA; Department of Parasitology, Leiden University Centre for Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands., Boss K; Department of Nephrology, University Hospital Essen, University Duisburg-Essen, Essen, Germany., van Duikeren S; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands., van Haften FJ; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands., Pardieck IN; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands., van der Gracht ET; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands., Vleeshouwers W; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands., van der Sluis TC; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands., de Graaf JF; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands., Veerkamp DM; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands., Franken KL; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands., Lei X; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands., van de Sand L; Department of Infectious Diseases, University Hospital Essen, University Duisburg-Essen, Essen, Germany., van der Burg SH; Department of Medical Oncology., Welters MJ; Department of Medical Oncology., Heidt S; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands., Huisman W; Department of Parasitology, Leiden University Centre for Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands., Jochems SP; Department of Parasitology, Leiden University Centre for Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands., Giera M; Center for Proteomics and Metabolomics, and., Witzke O; Department of Infectious Diseases, University Hospital Essen, University Duisburg-Essen, Essen, Germany., de Vries AP; Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands., Kribben A; Department of Nephrology, University Hospital Essen, University Duisburg-Essen, Essen, Germany., Everts B; Department of Parasitology, Leiden University Centre for Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands., Wilde B; Department of Nephrology, University Hospital Essen, University Duisburg-Essen, Essen, Germany., Arens R; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 Jul 02; Vol. 134 (17). Date of Electronic Publication: 2024 Jul 02.

The importance of correctly timing cancer immunotherapy.

Autor: Beyranvand Nejad E; a Department of Medical Oncology , Leiden University Medical Center , Leiden , The Netherlands.; b Department of Immunohematology and Blood Transfusion , Leiden University Medical Center , Leiden , The Netherlands., Welters MJ; a Department of Medical Oncology , Leiden University Medical Center , Leiden , The Netherlands., Arens R; b Department of Immunohematology and Blood Transfusion , Leiden University Medical Center , Leiden , The Netherlands., van der Burg SH; a Department of Medical Oncology , Leiden University Medical Center , Leiden , The Netherlands.

Publikováno v: Expert opinion on biological therapy [Expert Opin Biol Ther] 2017 Jan; Vol. 17 (1), pp. 87-103. Date of Electronic Publication: 2016 Nov 16.

Potential use of lymph node-derived HPV-specific T cells for adoptive cell therapy of cervical cancer.

Autor: van Poelgeest MI; Department of Gynecology, Leiden University Medical Center, Leiden, The Netherlands., Visconti VV; Department of Medical Oncology, Leiden University Medical Center, Building 1, K1-P, PO box 9600, 2300 RC, Leiden, The Netherlands.; Department of Microbiology Diagnostic, University of Rome 'La Sapienza', Rome, Italy., Aghai Z; Department of Medical Oncology, Leiden University Medical Center, Building 1, K1-P, PO box 9600, 2300 RC, Leiden, The Netherlands., van Ham VJ; Department of Medical Oncology, Leiden University Medical Center, Building 1, K1-P, PO box 9600, 2300 RC, Leiden, The Netherlands., Heusinkveld M; Department of Medical Oncology, Leiden University Medical Center, Building 1, K1-P, PO box 9600, 2300 RC, Leiden, The Netherlands.; Department of Medical Microbiology, Free University Medical Center, Amsterdam, The Netherlands., Zandvliet ML; Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands., Valentijn AR; Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands., Goedemans R; Department of Medical Oncology, Leiden University Medical Center, Building 1, K1-P, PO box 9600, 2300 RC, Leiden, The Netherlands., van der Minne CE; Department of Medical Oncology, Leiden University Medical Center, Building 1, K1-P, PO box 9600, 2300 RC, Leiden, The Netherlands., Verdegaal EM; Department of Medical Oncology, Leiden University Medical Center, Building 1, K1-P, PO box 9600, 2300 RC, Leiden, The Netherlands., Trimbos JB; Department of Gynecology, Leiden University Medical Center, Leiden, The Netherlands., van der Burg SH; Department of Medical Oncology, Leiden University Medical Center, Building 1, K1-P, PO box 9600, 2300 RC, Leiden, The Netherlands., Welters MJ; Department of Medical Oncology, Leiden University Medical Center, Building 1, K1-P, PO box 9600, 2300 RC, Leiden, The Netherlands. m.j.p.schoenmaekers-welters@lumc.nl.

Publikováno v: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2016 Dec; Vol. 65 (12), pp. 1451-1463. Date of Electronic Publication: 2016 Sep 12.

TLR2 ligand-synthetic long peptide conjugates effectively stimulate tumor-draining lymph node T cells of cervical cancer patients.

Autor: Zom GG; Department of Immunohematology and Blood Transfusion, Section Tumorimmunology, Leiden University Medical Center, Leiden, The Netherlands., Welters MJ; Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands., Loof NM; Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands., Goedemans R; Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands., Lougheed S; Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands., Valentijn RR; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands., Zandvliet ML; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands., Meeuwenoord NJ; Leiden Institute of Chemistry, University of Leiden, Leiden, The Netherlands., Melief CJ; Department of Immunohematology and Blood Transfusion, Section Tumorimmunology, Leiden University Medical Center, Leiden, The Netherlands.; ISA Pharmaceuticals BV, Leiden, The Netherlands., de Gruijl TD; Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands., Van der Marel GA; Leiden Institute of Chemistry, University of Leiden, Leiden, The Netherlands., Filippov DV; Leiden Institute of Chemistry, University of Leiden, Leiden, The Netherlands., Ossendorp F; Department of Immunohematology and Blood Transfusion, Section Tumorimmunology, Leiden University Medical Center, Leiden, The Netherlands., Van der Burg SH; Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands.

Publikováno v: Oncotarget [Oncotarget] 2016 Oct 11; Vol. 7 (41), pp. 67087-67100.

Vaccination against Oncoproteins of HPV16 for Noninvasive Vulvar/Vaginal Lesions: Lesion Clearance Is Related to the Strength of the T-Cell Response.

Autor: van Poelgeest MI; Department of Gynaecology, Leiden University Medical Centre, Leiden, the Netherlands., Welters MJ; Department of Clinical Oncology, Leiden University Medical Centre, Leiden, the Netherlands., Vermeij R; Department of Gynaecology, University Medical Centre Groningen, Groningen, the Netherlands., Stynenbosch LF; Department of Clinical Oncology, Leiden University Medical Centre, Leiden, the Netherlands., Loof NM; Department of Clinical Oncology, Leiden University Medical Centre, Leiden, the Netherlands., Berends-van der Meer DM; Department of Gynaecology, Leiden University Medical Centre, Leiden, the Netherlands., Löwik MJ; Department of Gynaecology, Leiden University Medical Centre, Leiden, the Netherlands., Hamming IL; Department of Gynaecology, University Medical Centre Groningen, Groningen, the Netherlands., van Esch EM; Department of Gynaecology, Leiden University Medical Centre, Leiden, the Netherlands., Hellebrekers BW; Department of Obstetrics and Gynaecology, Haga Teaching Hospital, the Hague, the Netherlands., van Beurden M; Netherlands Cancer Institute, Amsterdam, the Netherlands., Schreuder HW; Department of Obstetrics and Gynaecology, University Medical Centre Utrecht, Utrecht, the Netherlands., Kagie MJ; Department of Obstetrics and Gynaecology, Medical Centre Haaglanden, the Hague, the Netherlands., Trimbos JB; Department of Gynaecology, Leiden University Medical Centre, Leiden, the Netherlands., Fathers LM; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, the Netherlands., Daemen T; Department of Medical Microbiology, University Medical Centre Groningen, Groningen, the Netherlands., Hollema H; Department of Pathology and Medical Biology, University Medical Centre Groningen, Groningen, the Netherlands., Valentijn AR; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, the Netherlands., Oostendorp J; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, the Netherlands., Oude Elberink JH; Department of Allergy, Internal Medicine, Groningen Research Institute for Asthma and COPD, University Medical Centre Groningen, Groningen, the Netherlands., Fleuren GJ; Department of Pathology, Leiden University Medical Centre, Leiden, the Netherlands., Bosse T; Department of Pathology, Leiden University Medical Centre, Leiden, the Netherlands., Kenter GG; Department of Gynaecology, Academic Medical Centre, Amsterdam, the Netherlands., Stijnen T; Department of Medical Statistics and Bioinformatics, Leiden University Medical Centre, Leiden, the Netherlands., Nijman HW; Department of Gynaecology, University Medical Centre Groningen, Groningen, the Netherlands., Melief CJ; ISA Pharmaceuticals, Leiden, the Netherlands. Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, the Netherlands., van der Burg SH; Department of Clinical Oncology, Leiden University Medical Centre, Leiden, the Netherlands. shvdburg@lumc.nl.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2016 May 15; Vol. 22 (10), pp. 2342-50. Date of Electronic Publication: 2016 Jan 26.