The design of phenylglycine containing benzamidine carboxamides as potent and selective inhibitors of factor Xa

Autor: Jones, Stuart D, Liebeschuetz, John W, Morgan, Phillip J, Murray, Christopher W, Rimmer, Andrew D, Roscoe, Jonathan M.E, Waszkowycz, Bohdan, Welsh, Pauline M, Wylie, William A, Young, Stephen C, Martin, Harry, Mahler, Jacqui, Brady, Leo, Wilkinson, Kay

Publikováno v: In Bioorganic & Medicinal Chemistry Letters 2001 11(5):733-736

PRO_SELECT: combining structure-based drug design and array-based chemistry for rapid lead discovery. 2. The development of a series of highly potent and selective factor Xa inhibitors.

Autor: Liebeschuetz JW; Protherics Molecular Design, Beechfield House, Lyme Green Business Park, Macclesfield SK11 0JL, UK. jliebeschuetz@tularik.com, Jones SD, Morgan PJ, Murray CW, Rimmer AD, Roscoe JM, Waszkowycz B, Welsh PM, Wylie WA, Young SC, Martin H, Mahler J, Brady L, Wilkinson K

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2002 Mar 14; Vol. 45 (6), pp. 1221-32.