Do Pulmonary Ionocytes Absorb Chloride or Secrete Chloride?

Autor: Thornell IM; Department of Internal Medicine and Pappajohn Biomedical Institute Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, USA., Lei L; Stead Family Department of Pediatrics and Pappajohn Biomedical Institute Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA., McCray PB Jr; Stead Family Department of Pediatrics and Pappajohn Biomedical Institute Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.; Department of Microbiology and Immunology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, USA., Welsh MJ; Department of Internal Medicine and Pappajohn Biomedical Institute Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, USA.; Department of Molecular Physiology and Biophysics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, USA.; Howard Hughes Medical Institute, University of Iowa, Iowa City, USA.

Publikováno v: American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2024 Dec 23. Date of Electronic Publication: 2024 Dec 23.

Development and Initial Characterization of Pigs with DNAI1 Mutations and Primary Ciliary Dyskinesia.

Autor: Abou Alaiwa MA; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa 52242., Hilkin BM; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Price MP; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Gansemer ND; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Rector MR; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Stroik MR; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Powers LS; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Whitworth KM; Division of Animal Sciences, University of Missouri, Columbia, Missouri 65211., Samuel MS; Division of Animal Sciences, University of Missouri, Columbia, Missouri 65211., Jain A; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Ostedgaard LS; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Ernst SE; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Philibert W; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa 52242., Boyken LD; Department of Pathology, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Moninger TO; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Karp PH; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Hornick DB; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Sinn PL; Department of Pediatrics, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Fischer AJ; Department of Pediatrics, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Pezzulo AA; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., McCray PB Jr; Department of Pediatrics, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Meyerholz DK; Department of Pathology, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Zabner J; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242., Prather RS; Division of Animal Sciences, University of Missouri, Columbia, Missouri 65211., Welsh MJ; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Molecular Physiology and Biophysics, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Howard Hughes Medical Institute, University of Iowa, Iowa City, Iowa 52242., Stoltz DA; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Molecular Physiology and Biophysics, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa 52242.; Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa 52242.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Aug 21. Date of Electronic Publication: 2024 Aug 21.

Epithelial responses to CFTR modulators are improved by inflammatory cytokines and impaired by antiinflammatory drugs.

Autor: Rehman T; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Department of Internal Medicine, Pappajohn Biomedical Institute, University of Iowa, Iowa City, Iowa, USA., Pezzulo AA; Department of Internal Medicine, Pappajohn Biomedical Institute, University of Iowa, Iowa City, Iowa, USA., Thurman AL; Department of Internal Medicine, Pappajohn Biomedical Institute, University of Iowa, Iowa City, Iowa, USA., Zemans RL; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA., Welsh MJ; Department of Internal Medicine, Pappajohn Biomedical Institute, University of Iowa, Iowa City, Iowa, USA.; Howard Hughes Medical Institute, University of Iowa, Iowa City, Iowa, USA.

Publikováno v: JCI insight [JCI Insight] 2024 Jun 18; Vol. 9 (14). Date of Electronic Publication: 2024 Jun 18.

Arteriovenous metabolomics in pigs reveals CFTR regulation of metabolism in multiple organs.

Autor: Bae H; Department of Biological Chemistry, University of California - Irvine, Irvine, California, USA., Kim BR; Department of Internal Medicine, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.; Howard Hughes Medical Institute, University of Iowa, Iowa City, Iowa, USA., Jung S; Department of Biological Chemistry, University of California - Irvine, Irvine, California, USA., Le J; Department of Biological Chemistry, University of California - Irvine, Irvine, California, USA., van der Heide D; Department of Surgery and., Yu W; Department of Internal Medicine, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.; Howard Hughes Medical Institute, University of Iowa, Iowa City, Iowa, USA., Park SH; Department of Biological Chemistry, University of California - Irvine, Irvine, California, USA., Hilkin BM; Department of Internal Medicine, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA., Gansemer ND; Department of Internal Medicine, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA., Powers LS; Department of Internal Medicine, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA., Kang T; Department of Biological Chemistry, University of California - Irvine, Irvine, California, USA., Meyerholz DK; Department of Pathology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA., Schuster VL; Department of Internal Medicine, Albert Einstein College of Medicine, Bronx, New York, New York, USA., Jang C; Department of Biological Chemistry, University of California - Irvine, Irvine, California, USA.; Center for Complex Biological Systems and.; Center for Epigenetics and Metabolism, University of California - Irvine, Irvine, California, USA., Welsh MJ; Department of Internal Medicine, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.; Howard Hughes Medical Institute, University of Iowa, Iowa City, Iowa, USA.; Department of Molecular Physiology and Biophysics, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, Iowa, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 May 14; Vol. 134 (13). Date of Electronic Publication: 2024 May 14.

A model for stimulation of enzyme activity by a competitive inhibitor based on the interaction of terazosin and phosphoglycerate kinase 1.

Autor: Riley MJ; Department of Mathematics, University of Iowa, Iowa City, IA 52242.; Department of Internal Medicine, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242., Mitchell CC; Department of Mathematics, University of Iowa, Iowa City, IA 52242., Ernst SE; Department of Internal Medicine, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242.; HHMI, University of Iowa, Iowa City, IA 52242., Taylor EB; Department of Molecular Physiology and Biophysics, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242., Welsh MJ; Department of Internal Medicine, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242.; HHMI, University of Iowa, Iowa City, IA 52242.; Department of Molecular Physiology and Biophysics, Pappajohn Biomedical Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Feb 27; Vol. 121 (9), pp. e2318956121. Date of Electronic Publication: 2024 Feb 20.