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Genetic Disruption of Circadian Rhythms in the Suprachiasmatic Nucleus Causes Helplessness, Behavioral Despair, and Anxiety-like Behavior in Mice

Autor: Landgraf, D, Long, JE, Proulx, CD, Barandas, R, Malinow, R, Welsh, DK

Publikováno v: Biological psychiatry, vol 80, iss 11
Landgraf, D; Long, JE; Proulx, CD; Barandas, R; Malinow, R; & Welsh, DK. (2016). Genetic Disruption of Circadian Rhythms in the Suprachiasmatic Nucleus Causes Helplessness, Behavioral Despair, and Anxiety-like Behavior in Mice. BIOLOGICAL PSYCHIATRY, 80(11), 827-835. doi: 10.1016/j.biopsych.2016.03.1050. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/5z41x0p3

BackgroundMajor depressive disorder is associated with disturbed circadian rhythms. To investigate the causal relationship between mood disorders and circadian clock disruption, previous studies in animal models have employed light/dark manipulations

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Functional Contributions of Strong and Weak Cellular Oscillators to Synchrony and Light-shifted Phase Dynamics

Autor: Roberts, L, Leise, TL, Welsh, DK, Holmes, TC

Publikováno v: Journal of biological rhythms, vol 31, iss 4
Roberts, L; Leise, TL; Welsh, DK; & Holmes, TC. (2016). Functional Contributions of Strong and Weak Cellular Oscillators to Synchrony and Light-shifted Phase Dynamics. JOURNAL OF BIOLOGICAL RHYTHMS, 31(4), 337-351. doi: 10.1177/0748730416649550. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/12n4w0m8

Light is the primary signal that calibrates circadian neural circuits and thus coordinates daily physiological and behavioral rhythms with solar entrainment cues. Drosophila and mammalian circadian circuits consist of diverse populations of cellular

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Disinhibition of the extracellular-signal-regulated kinase restores the amplification of circadian rhythms by lithium in cells from bipolar disorder patients

Autor: McCarthy, MJ, Wei, H, Landgraf, D, Le Roux, MJ, Welsh, DK

Publikováno v: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, vol 26, iss 8
McCarthy, MJ; Wei, H; Landgraf, D; Le Roux, MJ; & Welsh, DK. (2016). Disinhibition of the extracellular-signal-regulated kinase restores the amplification of circadian rhythms by lithium in cells from bipolar disorder patients. European Neuropsychopharmacology, 26(8), 1310-1319. doi: 10.1016/j.euroneuro.2016.05.003. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/2rh187qd

© 2016 Bipolar disorder (BD) is characterized by depression, mania, and circadian rhythm abnormalities. Lithium, a treatment for BD stabilizes mood and increases circadian rhythm amplitude. However, in fibroblasts grown from BD patients, lithium has

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The mood stabilizer valproic acid opposes the effects of dopamine on circadian rhythms

Autor: Landgraf, D, Joiner, WJ, McCarthy, MJ, Kiessling, S, Barandas, R, Young, JW, Cermakian, N, Welsh, DK

Publikováno v: Landgraf, D; Joiner, WJ; McCarthy, MJ; Kiessling, S; Barandas, R; Young, JW; et al.(2016). The mood stabilizer valproic acid opposes the effects of dopamine on circadian rhythms. Neuropharmacology, 107, 262-270. doi: 10.1016/j.neuropharm.2016.03.047. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/1971215t

© 2016 Elsevier Ltd. All rights reserved. Endogenous circadian (∼24 h) clocks regulate key physiological and cognitive processes via rhythmic expression of clock genes. The main circadian pacemaker is the hypothalamic suprachiasmatic nucleus (SCN)

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Cardiomyocyte Circadian Oscillations Are Cell-Autonomous, Amplified by beta-Adrenergic Signaling, and Synchronized in Cardiac Ventricle Tissue

Autor: Beesley, S, Noguchi, T, Welsh, DK

Publikováno v: Beesley, S; Noguchi, T; & Welsh, DK. (2016). Cardiomyocyte Circadian Oscillations Are Cell-Autonomous, Amplified by beta-Adrenergic Signaling, and Synchronized in Cardiac Ventricle Tissue. PLOS ONE, 11(7). doi: 10.1371/journal.pone.0159618. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/2mx9520g

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Calcium channel genes associated with bipolar disorder modulate lithium's amplification of circadian rhythms

Autor: McCarthy, MJ, Le Roux, MJ, Wei, H, Beesley, S, Kelsoe, JR, Welsh, DK

Publikováno v: McCarthy, MJ; Le Roux, MJ; Wei, H; Beesley, S; Kelsoe, JR; & Welsh, DK. (2016). Calcium channel genes associated with bipolar disorder modulate lithium's amplification of circadian rhythms. Neuropharmacology, 101, 439-448. doi: 10.1016/j.neuropharm.2015.10.017. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/7s60q32m

UnlabelledBipolar disorder (BD) is associated with mood episodes and low amplitude circadian rhythms. Previously, we demonstrated that fibroblasts grown from BD patients show weaker amplification of circadian rhythms by lithium compared to control ce

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Circadian clock period inversely correlates with illness severity in cells from patients with alcohol use disorders

Autor: Mccarthy, MJ, Fernandes, M, Kranzler, HR, Covault, JM, Welsh, DK

Publikováno v: Alcoholism, clinical and experimental research, vol 37, iss 8
Mccarthy, MJ; Fernandes, M; Kranzler, HR; Covault, JM; & Welsh, DK. (2013). Circadian clock period inversely correlates with illness severity in cells from patients with alcohol use disorders. Alcoholism: Clinical and Experimental Research, 37(8), 1304-1310. doi: 10.1111/acer.12106. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/5hs4c999

Background: Clinical and genetic studies suggest circadian clock genes may contribute to biological mechanisms underlying alcohol use disorders (AUD). In particular, the Per2 gene regulates alcohol consumption in mutant animals, and in humans with AU

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Functional genetic variation in the Rev-Erbα pathway and lithium response in the treatment of bipolar disorder

Autor: McCarthy, MJ, Nievergelt, CM, Shekhtman, T, Kripke, DF, Welsh, DK, Kelsoe, JR

Publikováno v: Genes, brain, and behavior, vol 10, iss 8
Mccarthy, MJ; Nievergelt, CM; Shekhtman, T; Kripke, DF; Welsh, DK; & Kelsoe, JR. (2011). Functional genetic variation in the Rev-Erbα pathway and lithium response in the treatment of bipolar disorder. Genes, Brain and Behavior, 10(8), 852-861. doi: 10.1111/j.1601-183X.2011.00725.x. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/0jb7q8tj

Bipolar disorder (BD) is characterized by disruptions in circadian rhythms such as sleep and daily activity that often normalize after lithium treatment in responsive patients. As lithium is known to interact with the circadian clock, we hypothesized

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