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Motivation: This paper presents libRoadRunner 2.0, an extensible, high-performance, cross-platform, open-source software library for the simulation and analysis of models expressed using Systems Biology Markup Language SBML). Results: libRoadRunner i
Externí odkaz:
http://arxiv.org/abs/2203.01175
Akademický článek
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Autor:
Guimera, Alvaro Martinez, Welsh, Ciaran M, Proctor, Carole J, McArdle, Anne, Shanley, Daryl P
Publikováno v:
Mechanisms of Ageing and Development
MECHANISMS OF AGEING AND DEVELOPMENT
MECHANISMS OF AGEING AND DEVELOPMENT
Highlights • Constitutive signals indicate homeostatic dysregulation but their effect on signal transduction remains largely unexplored. • A theoretical approach is undertaken to examine how oxidative stress may affect redox signal transduction.
Akademický článek
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Akademický článek
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Autor:
Martinez Guimera, Alvaro, Welsh, Ciaran, Dalle Pezze, Piero, Fullard, Nicola, Nelson, Glyn, Roger, Mathilde F., Przyborski, Stefan A., Shanley, Daryl P.
Publikováno v:
Essays in biochemistry, 2017, Vol.61(3), pp.369-377 [Peer Reviewed Journal]
Systems modelling has been successfully used to investigate several key molecular mechanisms of ageing. Modelling frameworks to allow integration of models and methods to enhance confidence in models are now well established. In this article, we disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______328::95484d388d9dcdf745d83fa6d8b173bd
http://dro.dur.ac.uk/22408/1/22408.pdf
http://dro.dur.ac.uk/22408/1/22408.pdf
Autor:
Martinez Guimera, Alvaro1,2, Welsh, Ciaran M.1, Proctor, Carole J.2,3, McArdle, Anne2,4, Shanley, Daryl P.1,2 daryl.shanley@ncl.ac.uk
Publikováno v:
Mechanisms of Ageing & Development. Jan2018, Vol. 169, p53-62. 10p.
Autor:
Guimera, Alvaro Martinez, Welsh, Ciaran, Pezze, Piero Dalle, Fullard, Nicola, Nelson, Glyn, Roger, Mathilde F., Przyborski, Stefan A., Shanley, Daryl P.
Publikováno v:
Essays in Biochemistry; 7/11/2017, Vol. 61 Issue 3, p369-377, 9p
Autor:
Welsh C; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA., Xu J; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA., Smith L; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA., König M; Institute of Biology, Institute of Theoretical Biology, Humboldt-University Berlin, Berlin 10115, Germany., Choi K; School of Computational Sciences, Korea Institute for Advanced Study, Seoul 02455, Republic of Korea., Sauro HM; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA.
Publikováno v:
Bioinformatics (Oxford, England) [Bioinformatics] 2023 Jan 01; Vol. 39 (1).
Autor:
Martinez Guimera A; Institute for Cell and Molecular Biosciences, Campus for Ageing and Vitality, Newcastle Upon Tyne, U.K., Welsh C; Institute for Cell and Molecular Biosciences, Campus for Ageing and Vitality, Newcastle Upon Tyne, U.K., Dalle Pezze P; The Babraham Institute, Babraham Campus, Cambridge, U.K., Fullard N; School of Biological and Biomedical Sciences, Durham University, Durham, U.K., Nelson G; The Bio-Imaging Unit, William Leech Building, William Leech Building, Newcastle Upon Tyne, U.K., Roger MF; School of Biological and Biomedical Sciences, Durham University, Durham, U.K., Przyborski SA; School of Biological and Biomedical Sciences, Durham University, Durham, U.K., Shanley DP; Institute for Cell and Molecular Biosciences, Campus for Ageing and Vitality, Newcastle Upon Tyne, U.K. daryl.shanley@ncl.ac.uk.
Publikováno v:
Essays in biochemistry [Essays Biochem] 2017 Jul 11; Vol. 61 (3), pp. 369-377. Date of Electronic Publication: 2017 Jul 11 (Print Publication: 2017).