Auranofin inhibition of thioredoxin reductase sensitizes lung neuroendocrine tumor cells (NETs) and small cell lung cancer (SCLC) cells to sorafenib as well as inhibiting SCLC xenograft growth.

Autor: Johnson SS; Department of Radiation Oncology, Holden Comprehensive Cancer Center, Free Radical and Radiation Biology Program, University of Iowa Hospitals and Clinics, IA, USA., Liu D; Department Pediatrics, University of Iowa Hospitals and Clinics, IA, USA., Ewald JT; Department of Radiation Oncology, Holden Comprehensive Cancer Center, Free Radical and Radiation Biology Program, University of Iowa Hospitals and Clinics, IA, USA., Robles-Planells C; Department Pediatrics, University of Iowa Hospitals and Clinics, IA, USA., Pulliam C; Department of Radiation Oncology, Holden Comprehensive Cancer Center, Free Radical and Radiation Biology Program, University of Iowa Hospitals and Clinics, IA, USA., Christensen KA; Department of Radiation Oncology, Holden Comprehensive Cancer Center, Free Radical and Radiation Biology Program, University of Iowa Hospitals and Clinics, IA, USA., Bayanbold K; Department of Radiation Oncology, Holden Comprehensive Cancer Center, Free Radical and Radiation Biology Program, University of Iowa Hospitals and Clinics, IA, USA., Wels BR; State Hygienic Laboratory, University of Iowa, IA, USA., Solst SR; Department of Radiation Oncology, Holden Comprehensive Cancer Center, Free Radical and Radiation Biology Program, University of Iowa Hospitals and Clinics, IA, USA., O'Dorisio MS; Department Pediatrics, University of Iowa Hospitals and Clinics, IA, USA., Menda Y; Department of Radiology, Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, IA, USA., Spitz DR; Department of Radiation Oncology, Holden Comprehensive Cancer Center, Free Radical and Radiation Biology Program, University of Iowa Hospitals and Clinics, IA, USA., Fath MA; Department of Radiation Oncology, Holden Comprehensive Cancer Center, Free Radical and Radiation Biology Program, University of Iowa Hospitals and Clinics, IA, USA.

Publikováno v: Cancer biology & therapy [Cancer Biol Ther] 2024 Dec 31; Vol. 25 (1), pp. 2382524. Date of Electronic Publication: 2024 Jul 25.

Disulfiram causes selective hypoxic cancer cell toxicity and radio-chemo-sensitization via redox cycling of copper.

Autor: Falls-Hubert KC; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA., Butler AL; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA., Gui K; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA., Anderson M; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA., Li M; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA; Department of Radiology, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA., Stolwijk JM; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA., Rodman SN 3rd; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA., Solst SR; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA., Tomanek-Chalkley A; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA., Searby CC; Department Pediatrics, University of Iowa, Iowa City, IA, 52242, USA; Department Ophthalmology, University of Iowa, Iowa City, IA, 52242, USA., Sheffield VC; Department Pediatrics, University of Iowa, Iowa City, IA, 52242, USA; Department Ophthalmology, University of Iowa, Iowa City, IA, 52242, USA., Sandfort V; Gastroenterology and Hepatology, Münster University Hospital (UKM), Münster, Germany., Schmidt H; Gastroenterology and Hepatology, Münster University Hospital (UKM), Münster, Germany., McCormick ML; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA., Wels BR; State Hygienic Lab, University of Iowa, Ankeny, IA, 50023, USA., Allen BG; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA., Buettner GR; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA., Schultz MK; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA; Department of Radiology, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA; Department Pediatrics, University of Iowa, Iowa City, IA, 52242, USA; Department of Chemistry, University of Iowa, Iowa City, IA, 52241, USA., Spitz DR; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA. Electronic address: Douglas-spitz@uiowa.edu.

Publikováno v: Free radical biology & medicine [Free Radic Biol Med] 2020 Apr; Vol. 150, pp. 1-11. Date of Electronic Publication: 2020 Feb 04.

Dietary Manganese Modulates PCB126 Toxicity, Metal Status, and MnSOD in the Rat.

Autor: Wang B; The Interdisciplinary Graduate Program in Human Toxicology and., Klaren WD; The Interdisciplinary Graduate Program in Human Toxicology and., Wels BR; State Hygienic Laboratory, The University of Iowa, Iowa City, Iowa;, Simmons DL; State Hygienic Laboratory, The University of Iowa, Iowa City, Iowa;, Olivier AK; Department of Pathobiology and Population Medicine, Mississippi State University College of Veterinary Medicine, Statesville, Mississippi;, Wang K; Department of Biostatistics and., Robertson LW; The Interdisciplinary Graduate Program in Human Toxicology and Department of Occupational and Environmental Health, College of Public Health, The University of Iowa, Iowa City, Iowa., Ludewig G; The Interdisciplinary Graduate Program in Human Toxicology and Department of Occupational and Environmental Health, College of Public Health, The University of Iowa, Iowa City, Iowa. gabriele-ludewig@uiowa.edu.

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2016 Mar; Vol. 150 (1), pp. 15-26. Date of Electronic Publication: 2015 Dec 10.