Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Wells W Wu"'
Publikováno v:
eLife, Vol 12 (2023)
Newborns are unable to reach the adult-level humoral immune response partly due to the potent immunoregulatory role of IL-10. Increased IL-10 production by neonatal B cells has been attributed to the larger population of IL-10-producting CD43+ B-1 ce
Externí odkaz:
https://doaj.org/article/fd02de73280644fe9435795f9e7b3524
Autor:
Francesca Mascia, Ilya Mazo, Wei-Lun Alterovitz, Konstantinos Karagiannis, Wells W Wu, Rong-Fong Shen, Julia A Beaver, V Ashutosh Rao
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0262134 (2022)
Autophagy drives drug resistance and drug-induced cancer cell cytotoxicity. Targeting the autophagy process could greatly improve chemotherapy outcomes. The discovery of specific inhibitors or activators has been hindered by challenges with reliably
Externí odkaz:
https://doaj.org/article/f0155e8dbb3f4fd0956c34821514efd1
Autor:
Gabriel Silva, Mozart Marins, Nadda Chaichanasak, Yongdae Yoon, Ana Lúcia Fachin, Vitor Caressato Pinhanelli, Luis Octávio Regasini, Mariana Bastos Dos Santos, Gabriela Miranda Ayusso, Beatriz de Carvalho Marques, Wells W Wu, Je-Nie Phue, Rong-Fong Shen, Seung Joon Baek
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202263 (2018)
Naturally-occurring chalcones and synthetic chalcone analogues have been demonstrated to have many biological effects, including anti-inflammatory, anti-malarial, anti-fungal, and anti-oxidant/anti-cancerous activities. Compared to other chalcones, t
Externí odkaz:
https://doaj.org/article/c4a2f866cc5149068acd7afa844eeab7
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182909 (2017)
Clostridium tetani and Clostridium botulinum produce two of the most potent neurotoxins known, tetanus neurotoxin and botulinum neurotoxin, respectively. Extensive biochemical and genetic investigation has been devoted to identifying and characterizi
Externí odkaz:
https://doaj.org/article/41d703251a5b4780b0ac7d4ff90eef23
Autor:
Wells W. Wu, Je-Nie Phue, Chun-Ting Lee, Changyi Lin, Lai Xu, Rong Wang, Yaqin Zhang, Rong-Fong Shen
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-10 (2018)
Abstract Background Current library preparation protocols for Illumina HiSeq and MiSeq DNA sequencers require ≥2 nM initial library for subsequent loading of denatured cDNA onto flow cells. Such amounts are not always attainable from samples having
Externí odkaz:
https://doaj.org/article/4ed2709f68ab46d89809b8cb8c9ea9ac
Autor:
Qiong Wang, Tiexin Wang, Wells W. Wu, Chang-Yi Lin, Shuang Yang, Ganglong Yang, Ewa Jankowska, Yifeng Hu, Rong-Fong Shen, Michael J. Betenbaugh, John F. Cipollo
Publikováno v:
Journal of Proteome Research. 21:2341-2355
Glycoproteomic analysis of three Chinese hamster ovary (CHO) suspension host cell lines (CHO-K1, CHO-S, and CHO-Pro5) commonly utilized in biopharmaceutical settings for recombinant protein production is reported. Intracellular and secreted glycoprot
Autor:
Amy Rosenberg, Yaqin Zhang, Hartmut Juhl, Rong-Fong Shen, Wells W. Wu, Rong Wang, Joseph Ziegelbauer, Lai Xu
Table S1. Tumor sample and patient information; Table S2a. 9 upregulated MT-tRNAs; Table. S2b. 13 upregulated snoRNAs; Table. S2c. 19 downregulated snoRNAs; Table S3: CRC tumor fingerprint based on T/N PRKM ratio (1); Figure S1. RPKMs of snord12 clus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7c74fd6efa2f58b86ebe08abef6bd4
https://doi.org/10.1158/1078-0432.22461573
https://doi.org/10.1158/1078-0432.22461573
Autor:
Amy Rosenberg, Yaqin Zhang, Hartmut Juhl, Rong-Fong Shen, Wells W. Wu, Rong Wang, Joseph Ziegelbauer, Lai Xu
Purpose: To gain insight into factors involved in tumor progression and metastasis, we examined the role of noncoding RNAs in the biologic characteristics of colorectal carcinoma, in paired samples of tumor together with normal mucosa from the same c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5166b9d29a87a512fa7106c596cdd6a4
https://doi.org/10.1158/1078-0432.c.6524823
https://doi.org/10.1158/1078-0432.c.6524823
Autor:
So Jin Bing, Sune Justesen, Wells W. Wu, Abdul Mohin Sajib, Stephanee Warrington, Alan Baer, Stephan Thorgrimsen, Rong-Fong Shen, Ronit Mazor
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss, Pp 255-267 (2022)
Despite the high safety profile demonstrated in clinical trials, the immunogenicity of adeno-associated virus (AAV)-mediated gene therapy remains a major hurdle. Specifically, T-cell-mediated immune responses to AAV vectors are related to loss of eff
Autor:
Shufeng Liu, Charles B. Stauft, Prabhuanand Selvaraj, Prabha Chandrasekaran, Felice D’Agnillo, Chao-Kai Chou, Wells W. Wu, Christopher Z. Lien, Clement A. Meseda, Cyntia L. Pedro, Matthew F. Starost, Jerry P. Weir, Tony T. Wang
Publikováno v:
Nature Communications. 13
Few live attenuated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are in pre-clinical or clinical development. We seek to attenuate SARS-CoV-2 (isolate WA1/2020) by removing the polybasic insert within the spike protein and th