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pro vyhledávání: '"Wells S. Brown"'
Therapeutic targeting of late-stage breast cancer is limited by an inadequate understanding of how tumor cell signaling evolves during metastatic progression and by the currently available small molecule inhibitors capable of targeting these processe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::848565d88788554d2d03a8b75e777049
https://doi.org/10.1158/1535-7163.c.6539268.v1
https://doi.org/10.1158/1535-7163.c.6539268.v1
This file includes supplementary figures S1-S8 and supplementary tables S1-S3.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e94671d702c4313c16c61a8e96d08d3
https://doi.org/10.1158/1535-7163.22509324
https://doi.org/10.1158/1535-7163.22509324
Autor:
Michael K. Wendt, Robert L. Geahlen, Casey J. Krusemark, Christopher D. Willey, Herbert Levine, Jun Wan, Sheng Liu, Jason T. George, Wells S. Brown, Ryan B. Khodadadi, Joshua C. Anderson, Wen-Hung Wang, Mohit Kumar Jolly, Saeed Salehin Akhand, Dongwook Kim, Shana D. Hardy, Aparna Shinde
The table lists the phosphorylation values for the array of peptides containing tyrosine or serine/threonine phosphorylation sites. This array was used to compare lysates from HME2 parental cells, TGF-beta-induced EMT and lapatinib-induced EMT.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::439a0bd9328f99e1cd5b4282254d11f0
https://doi.org/10.1158/0008-5472.22423922.v1
https://doi.org/10.1158/0008-5472.22423922.v1
Autor:
Michael K. Wendt, Robert L. Geahlen, Casey J. Krusemark, Christopher D. Willey, Herbert Levine, Jun Wan, Sheng Liu, Jason T. George, Wells S. Brown, Ryan B. Khodadadi, Joshua C. Anderson, Wen-Hung Wang, Mohit Kumar Jolly, Saeed Salehin Akhand, Dongwook Kim, Shana D. Hardy, Aparna Shinde
The ability of breast cancer cells to transiently transition between epithelial and mesenchymal states contributes to their metastatic potential. Therefore, driving tumor cells into a stable mesenchymal state, as opposed to complete tumor cell eradic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08debc21e5bb4b38529f9a60a880bdad
https://doi.org/10.1158/0008-5472.c.6511613.v1
https://doi.org/10.1158/0008-5472.c.6511613.v1
Autor:
Michael K. Wendt, Robert L. Geahlen, Casey J. Krusemark, Christopher D. Willey, Herbert Levine, Jun Wan, Sheng Liu, Jason T. George, Wells S. Brown, Ryan B. Khodadadi, Joshua C. Anderson, Wen-Hung Wang, Mohit Kumar Jolly, Saeed Salehin Akhand, Dongwook Kim, Shana D. Hardy, Aparna Shinde
This file contain supplemental figures S1 through S4. These figures present additional immunoblot and replicate immune fluorescent frames to further support the conclusions made from the data presented in the main manuscript.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::073a791bbda683c102e22c6381dd9b1c
https://doi.org/10.1158/0008-5472.22423928
https://doi.org/10.1158/0008-5472.22423928
Autor:
Saeed S. Akhand, Juan Sebastian Paez, Wells S. Brown, Sarah Libring, W. Andy Tao, Ammara Abdullah, Luis Solorio, Michael Badamy, Emily Dykuizen, Michael K. Wendt, Li Pan
Publikováno v:
Oncogene
Human epidermal growth factor receptor 2 (HER2)-amplified breast cancers are treated using targeted antibodies and kinase inhibitors, but resistance to these therapies leads to systemic tumor recurrence of metastatic disease. Herein, we conducted gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e6c312ed40a42df7ed14409a0e202c
https://doi.org/10.1038/s41388-020-01530-6
https://doi.org/10.1038/s41388-020-01530-6
Autor:
Geetha Venkateswaran, Shawn C. Chafe, Wells S. Brown, Zachary J. Gerbec, Paul C. McDonald, Shannon Awrey, Seth J. Parker, Shoukat Dedhar
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d639a2baaeb5d687b1295ebe7299970c
https://doi.org/10.2139/ssrn.4193121
https://doi.org/10.2139/ssrn.4193121
Autor:
Shawn C. Chafe, Franco J. Vizeacoumar, Ling Huang, Wells S. Brown, Paul C. McDonald, Oksana Nemirovsky, Fabrizio Carta, Shannon Awrey, Frederick S. Vizeacoumar, David F. Schaeffer, Andrew Metcalfe, Claudiu T. Supuran, Senthil K. Muthuswamy, Daniel J. Renouf, Geetha Venkateswaran, Shoukat Dedhar, Joanna M. Karasinska
Publikováno v:
Science Advances
Targeting carbonic anhydrase IX acidifies intracellular pH, disrupts redox homeostasis, and creates vulnerability to ferroptosis.
The metabolic mechanisms involved in the survival of tumor cells within the hypoxic niche remain unclear. We carrie
The metabolic mechanisms involved in the survival of tumor cells within the hypoxic niche remain unclear. We carrie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd47dea0affc99bdf23744ab25a6bbac
https://doi.org/10.1126/sciadv.abj0364
https://doi.org/10.1126/sciadv.abj0364
Autor:
Jordan A. Gillespie, Saeed Saberi, James T. Topham, Joanna M. Karasinska, Oksana Nemirovsky, Claudiu T. Supuran, Shawn C. Chafe, Ali Bashashati, Jinyang Li, David F. Schaeffer, Ben Z. Stanger, Paul C. McDonald, Shoukat Dedhar, Geetha Venkateswaran, Daniel J. Renouf, Wells S. Brown, Steve E. Kalloger, Sohrab P. Shah, Mridula Swayampakula, Donald T. T. Yapp
Publikováno v:
Gastroenterology. 157:823-837
Background & Aims Most pancreatic ductal adenocarcinomas (PDACs) express an activated form of KRAS, become hypoxic and dysplastic, and are refractory to chemo and radiation therapies. To survive in the hypoxic environment, PDAC cells upregulate enzym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf9a1fd14ff4548e38379f4052a60bd
https://doi.org/10.1053/j.gastro.2019.05.004
https://doi.org/10.1053/j.gastro.2019.05.004
Autor:
Shana D. Hardy, Jun Wan, Mohit Kumar Jolly, Sheng Liu, Jason T. George, Michael K. Wendt, Robert L. Geahlen, Ryan B. Khodadadi, Aparna Shinde, Wells S. Brown, Herbert Levine, Christopher D. Willey, Dongwook Kim, Joshua C. Anderson, Wen-Hung Wang, Casey J. Krusemark, Saeed S. Akhand
Publikováno v:
Cancer Research. 79:1831-1843
The ability of breast cancer cells to transiently transition between epithelial and mesenchymal states contributes to their metastatic potential. Therefore, driving tumor cells into a stable mesenchymal state, as opposed to complete tumor cell eradic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a18ee91db4718c609eb30e91818ddff
https://doi.org/10.1158/0008-5472.can-18-2636
https://doi.org/10.1158/0008-5472.can-18-2636