A structural and dynamic model for the interaction of interleukin-8 and glycosaminoglycans: support from isothermal fluorescence titrations

Autor: Krieger, E., Geretti, E, Brandner, B, Goger, B, Wells, TN, Kungl, AJ

Publikováno v: Proteins-Structure Function and Bioinformatics, 54, 4, pp. 768-75
Proteins-Structure Function and Bioinformatics, 54, 768-75

Contains fulltext : 60567.pdf (Publisher’s version ) (Closed access) Binding of interleukin-8 (IL-8) to glycosaminoglycans (GAGs) on the surface of endothelial cells is crucial for the recruitment of neutrophils to an inflammatory site. Deriving st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f33780cda523d402ce8fddd02562ee3b
https://hdl.handle.net/2066/60567

Constrained Volume Micro- and Nanoparticle Collection Methods in Microfluidic Systems.

Autor: Wells TN; Department of Electrical and Computer Engineering, Brigham Young University, Provo, UT 84602, USA., Schmidt H; School of Engineering, University of California Santa Cruz, Santa Cruz, CA 95064, USA., Hawkins AR; Department of Electrical and Computer Engineering, Brigham Young University, Provo, UT 84602, USA.

Publikováno v: Micromachines [Micromachines (Basel)] 2024 May 25; Vol. 15 (6). Date of Electronic Publication: 2024 May 25.

The antimalarial pipeline.

Autor: Hooft van Huijsduijnen R; Medicines for Malaria Venture, 20 route de Pre-Bois, 1215 Geneva, Switzerland., Wells TN; Medicines for Malaria Venture, 20 route de Pre-Bois, 1215 Geneva, Switzerland. Electronic address: wellst@mmv.org.

Publikováno v: Current opinion in pharmacology [Curr Opin Pharmacol] 2018 Oct; Vol. 42, pp. 1-6. Date of Electronic Publication: 2018 May 31.

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles.

Autor: Williamson AE; School of Chemistry, The University of Sydney , Sydney, New South Wales 2006, Australia., Ylioja PM; School of Chemistry, The University of Sydney , Sydney, New South Wales 2006, Australia., Robertson MN; School of Chemistry, The University of Sydney , Sydney, New South Wales 2006, Australia., Antonova-Koch Y; Department of Pediatrics, Pharmacology & Drug Development, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States., Avery V; Discovery Biology, Eskitis Institute for Drug Discovery, Griffith University , Nathan, Queensland 4111, Australia., Baell JB; Monash Institute of Pharmaceutical Sciences, Monash University , 381 Royal Parade, Parkville, Victoria 3052, Australia., Batchu H; CSIR-Central Drug Research Institute , Sector 10, Jankipuram Extension, Sitapur Road, Lucknow, 226 031, India., Batra S; CSIR-Central Drug Research Institute , Sector 10, Jankipuram Extension, Sitapur Road, Lucknow, 226 031, India., Burrows JN; Medicines for Malaria Venture , PO Box 1826, 20 rte de Pre-Bois, 1215 Geneva 15, Switzerland., Bhattacharyya S; CSIR-Central Drug Research Institute , Sector 10, Jankipuram Extension, Sitapur Road, Lucknow, 226 031, India., Calderon F; Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain., Charman SA; Monash Institute of Pharmaceutical Sciences, Monash University , 381 Royal Parade, Parkville, Victoria 3052, Australia., Clark J; Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital , MS 1000, Room E9050, 262 Danny Thomas Place, Memphis, Tennessee 38105-3678, United States., Crespo B; Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain., Dean M; School of Chemistry, The University of Sydney , Sydney, New South Wales 2006, Australia., Debbert SL; Department of Chemistry, Lawrence University , 233 Steitz Science Hall, 711 East Boldt Way, Appleton, Wisconsin 54911, United States., Delves M; Department of Life Sciences, Imperial College London , South Kensington, London SW7 2AZ, U.K., Dennis AS; Research School of Biology, The Australian National University , Canberra, ACT 2601, Australia., Deroose F; Asclepia Outsourcing Solutions , Damvalleistraat 49, B-9070 Destelbergen, Belgium., Duffy S; Discovery Biology, Eskitis Institute for Drug Discovery, Griffith University , Nathan, Queensland 4111, Australia., Fletcher S; Discovery Biology, Eskitis Institute for Drug Discovery, Griffith University , Nathan, Queensland 4111, Australia., Giaever G; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto , 160 College Street, Toronto, Ontario M5S 3E1, Canada., Hallyburton I; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee , Dundee, DD1 5EH, U.K., Gamo FJ; Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain., Gebbia M; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto , 160 College Street, Toronto, Ontario M5S 3E1, Canada., Guy RK; Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital , MS 1000, Room E9050, 262 Danny Thomas Place, Memphis, Tennessee 38105-3678, United States., Hungerford Z; School of Chemistry, The University of Sydney , Sydney, New South Wales 2006, Australia., Kirk K; Research School of Biology, The Australian National University , Canberra, ACT 2601, Australia., Lafuente-Monasterio MJ; Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline , Severo Ochoa 2, 28760 Tres Cantos, Spain., Lee A; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto , 160 College Street, Toronto, Ontario M5S 3E1, Canada., Meister S; Department of Pediatrics, Pharmacology & Drug Development, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States., Nislow C; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto , 160 College Street, Toronto, Ontario M5S 3E1, Canada., Overington JP; European Molecular Biology Laboratory-European Bioinformatics Institute , Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, U.K., Papadatos G; European Molecular Biology Laboratory-European Bioinformatics Institute , Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, U.K., Patiny L; Institute of Chemical Sciences and Engineering (ISIC), Ecole Polytechnique Fédérale de Lausanne (EPFL) , Lausanne 1015, Switzerland., Pham J; Department of Biochemistry & Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne , Melbourne, Victoria 3010, Australia., Ralph SA; Department of Biochemistry & Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne , Melbourne, Victoria 3010, Australia., Ruecker A; Department of Life Sciences, Imperial College London , South Kensington, London SW7 2AZ, U.K., Ryan E; Monash Institute of Pharmaceutical Sciences, Monash University , 381 Royal Parade, Parkville, Victoria 3052, Australia., Southan C; IUPHAR/BPS Guide to PHARMACOLOGY, Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh , Edinburgh, EH8 9XD, U.K., Srivastava K; CSIR-Central Drug Research Institute , Sector 10, Jankipuram Extension, Sitapur Road, Lucknow, 226 031, India., Swain C; Cambridge MedChem Consulting , 8 Mangers Lane, Duxford, Cambridge CB22 4RN, U.K., Tarnowski MJ; School of Chemistry, The University of Sydney , Sydney, New South Wales 2006, Australia., Thomson P; School of Chemistry, The University of Edinburgh , Joseph Black Building, West Mains Road, Edinburgh EH9 3JJ, U.K., Turner P; School of Chemistry, The University of Sydney , Sydney, New South Wales 2006, Australia., Wallace IM; European Molecular Biology Laboratory-European Bioinformatics Institute , Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, U.K., Wells TN; Medicines for Malaria Venture , PO Box 1826, 20 rte de Pre-Bois, 1215 Geneva 15, Switzerland., White K; Monash Institute of Pharmaceutical Sciences, Monash University , 381 Royal Parade, Parkville, Victoria 3052, Australia., White L; School of Chemistry, The University of Sydney , Sydney, New South Wales 2006, Australia., Willis P; Medicines for Malaria Venture , PO Box 1826, 20 rte de Pre-Bois, 1215 Geneva 15, Switzerland., Winzeler EA; Department of Pediatrics, Pharmacology & Drug Development, University of California San Diego , 9500 Gilman Drive, La Jolla, California 92093, United States., Wittlin S; Swiss Tropical and Public Health Institute , Socinstrasse 57, 4051 Basel, Switzerland., Todd MH; School of Chemistry, The University of Sydney , Sydney, New South Wales 2006, Australia.

Publikováno v: ACS central science [ACS Cent Sci] 2016 Oct 26; Vol. 2 (10), pp. 687-701. Date of Electronic Publication: 2016 Sep 14.

Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development.

Autor: McCarthy JS; QIMR Berghofer Medical Research Institute, Brisbane, Australia University of Queensland, Brisbane, Australia., Marquart L; QIMR Berghofer Medical Research Institute, Brisbane, Australia., Sekuloski S; QIMR Berghofer Medical Research Institute, Brisbane, Australia., Trenholme K; QIMR Berghofer Medical Research Institute, Brisbane, Australia University of Queensland, Brisbane, Australia., Elliott S; QPharm Pty. Ltd., Brisbane, Australia., Griffin P; QIMR Berghofer Medical Research Institute, Brisbane, Australia University of Queensland, Brisbane, Australia QPharm Pty. Ltd., Brisbane, Australia Mater Health Services, Brisbane, Australia., Rockett R; University of Queensland, Brisbane, Australia Queensland Paediatric Infectious Diseases (QPID), Herston, Australia., O'Rourke P; QIMR Berghofer Medical Research Institute, Brisbane, Australia., Sloots T; University of Queensland, Brisbane, Australia Queensland Paediatric Infectious Diseases (QPID), Herston, Australia., Angulo-Barturen I; GlaxoSmithKline, Tres Cantos Drug Development Campus, Diseases of the Developing World, Tres Cantos, Spain., Ferrer S; GlaxoSmithKline, Tres Cantos Drug Development Campus, Diseases of the Developing World, Tres Cantos, Spain., Jiménez-Díaz MB; GlaxoSmithKline, Tres Cantos Drug Development Campus, Diseases of the Developing World, Tres Cantos, Spain., Martínez MS; GlaxoSmithKline, Tres Cantos Drug Development Campus, Diseases of the Developing World, Tres Cantos, Spain., Hooft van Huijsduijnen R; Medicines for Malaria Venture, Geneva, Switzerland., Duparc S; Medicines for Malaria Venture, Geneva, Switzerland., Leroy D; Medicines for Malaria Venture, Geneva, Switzerland., Wells TN; Medicines for Malaria Venture, Geneva, Switzerland., Baker M; Medicines for Malaria Venture, Geneva, Switzerland., Möhrle JJ; Medicines for Malaria Venture, Geneva, Switzerland moehrlej@mmv.org.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2016 May 23; Vol. 60 (6), pp. 3669-75. Date of Electronic Publication: 2016 May 23 (Print Publication: 2016).