Intranasal and intrapulmonary vaccination with an M protein-deficient respiratory syncytial virus (RSV) vaccine improves clinical signs and reduces viral replication in infant baboons after an RSV challenge infection.

Autor: Ivanov V; Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, 1100 North Lindsay Ave., Oklahoma City, OK 73104, USA. Electronic address: Vadim-Ivanov@OUHSC.edu., Oomens AGP; Department of Veterinary Pathology, College of Veterinary Medicine, Room 258 McElroy Hall, Oklahoma State University, Stillwater, OK 74074, USA. Electronic address: Oomens@OKState.edu., Papin JF; Division of Comparative Medicine, The University of Oklahoma, Health Sciences Center, 940 Stanton L. Young Blvd., Oklahoma City, OK 73104, USA. Electronic address: James-Papin@OUHSC.edu., Staats R; Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, 1100 North Lindsay Ave., Oklahoma City, OK 73104, USA. Electronic address: Rachel-Staats@OUHSC.edu., Reuter DN; Division of Comparative Medicine, The University of Oklahoma, Health Sciences Center, 940 Stanton L. Young Blvd., Oklahoma City, OK 73104, USA. Electronic address: Darlene-Reuter@OUHSC.edu., Yu Z; Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, 1100 North Lindsay Ave., Oklahoma City, OK 73104, USA. Electronic address: Zhongxin-Yu@OUHSC.edu., Piedra PA; Department of Molecular Biology and Microbiology and Pediatrics, Baylor College of Medicine, Baylor University, 1 Baylor Plaza, Houston, TX 77030, USA. Electronic address: PPiedra@BCM.edu., Wellliver RC Sr; Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, 1100 North Lindsay Ave., Oklahoma City, OK 73104, USA. Electronic address: Robert-Welliver@OUHSC.edu.

Publikováno v: Vaccine [Vaccine] 2021 Jul 05; Vol. 39 (30), pp. 4063-4071. Date of Electronic Publication: 2021 Jun 14.